The Phycotoxin Domoic Acid as a Potential Factor for Oxidative Alterations Enhanced by Climate Change

Cabrera, Joaquin; González, Paula Mariela; Puntarulo, Susana

doi:10.3389/fpls.2020.576971

Cited by 8 publications

(5 citation statements)

References 54 publications

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“…DA could bind with particulate Fe(III) in the water, and by its oxidation release soluble Fe(II), therefore being bioavailable for Pseudo-nitzschia [ 3 , 55 ]. The formation of a Fe-DA complex could play an active role in the increase of ROS generation, both in producing and non-phycotoxin producing species [ 56 ]. Studies with dDA and exudates from toxic Pseudo-nitzschia sp.…”

Section: Discussionmentioning

confidence: 99%

Domoic Acid Oxidative Effects on the Microalgae Phaeodactylum tricornutum

Cabrera

Puntarulo

González

2023

Life

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Domoic acid (DA) is a natural occurring marine biotoxin. Oxidative stress generation due to DA exposure was reported in animals, but little is known on the phytoplankton community. The aim of this work was to verify whether exposure to DA in the marine diatom Phaeodactylum tricornutum favors reactive oxygen species (ROS) generation in the intracellular environment modifying its antioxidant capacity. Active species production, non-enzymatic antioxidant content, and antioxidant enzyme activities over the three growth phases of P. tricornutum exposed to 64 µM DA were evaluated. Results obtained in exponential growing cells showed a time-depending seven-fold increase in the 2′,7′ dichlorofluorescein diacetate dye oxidation rate. Superoxide dismutase and catalase activities showed a two-fold increase, and glutathione related enzymes activities were also significantly increased in treated diatoms as compared to controls. However, glutathione and ascorbate contents significantly decreased after incubation of the cells with DA. Similar effects were observed in latent and stationary phases of cell development. These results showed that DA could cause a severe oxidant-dependent impact on a non-toxic algae.

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Section: Discussionmentioning

confidence: 99%

Domoic Acid Oxidative Effects on the Microalgae Phaeodactylum tricornutum

Cabrera

Puntarulo

González

2023

Life

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“…This agrees with the results obtained by Song et al [ 28 ] that showed that domoic acid induces oxidative stress and impairs defence mechanisms in bay scallops ( Argopecten irradians ). The contribution of oxidative stress to the effects and toxicity of domoic acid has been highlighted by several authors [ 6 , 28 , 31 , 32 , 33 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…The results obtained showed the differential expression of genes involved in protection against oxidative stress, the metabolism of xenobiotics (detoxification), transmembrane transport, and immunological processes [ 29 , 30 ]. Oxidative stress is one of the principal effects caused by exposure to domoic acid in vertebrates [ 31 , 32 , 33 , 34 ], and also in invertebrates [ 35 , 36 ], including marine bivalves ( Argopecten irradians [ 28 ] and Aequipecten opecularis [ 30 ]), and can play an important role in domoic acid induced toxicity. In the present work, a transcriptomic approach (RNA-seq) has been used to identify the genes differentially expressed in the digestive gland of the king scallop P. maximus after the injection of domoic acid, in order to uncover dysregulated biological and molecular processes and contribute to the knowledge of detoxification mechanisms in bivalves.…”

Section: Introductionmentioning

confidence: 99%

Transcriptional Response in the Digestive Gland of the King Scallop (Pecten maximus) After the Injection of Domoic Acid

Ventoso

Pazos

Blanco

et al. 2021

Toxins

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Some diatom species of the genus Pseudo-nitzschia produce the toxin domoic acid. The depuration rate of domoic acid in Pecten maximus is very low; for this reason, king scallops generally contain high levels of domoic acid in their tissues. A transcriptomic approach was used to identify the genes differentially expressed in the P. maximus digestive gland after the injection of domoic acid. The differential expression analysis found 535 differentially expressed genes (226 up-regulated and 309 down-regulated). Protein–protein interaction networks obtained with the up-regulated genes were enriched in gene ontology terms, such as vesicle-mediated transport, response to stress, signal transduction, immune system process, RNA metabolic process, and autophagy, while networks obtained with the down-regulated genes were enriched in gene ontology terms, such as response to stress, immune system process, ribosome biogenesis, signal transduction, and mRNA processing. Genes that code for cytochrome P450 enzymes, glutathione S-transferase theta-1, glutamine synthase, pyrroline-5-carboxylate reductase 2, and sodium- and chloride-dependent glycine transporter 1 were among the up-regulated genes. Therefore, a stress response at the level of gene expression, that could be caused by the domoic acid injection, was evidenced by the alteration of several biological, cellular, and molecular processes.

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“…Among these, changing oceanic chemistry, rising sea surface temperatures, and shifting oceanic currents are set to yield a vast array of negative impacts on marine ecosystems worldwide [ 3 , 4 ]. The past few decades have revealed an increasing understanding of the potential for marine climate change to significantly impact the frequency, magnitude, and geographical extent of harmful algal blooms (HAB) [ 5 , 6 , 7 ]. These phenomena have gained a particular degree of notoriety in the past few years due to their role in a wide variety of environmental issues [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Impacts of Climate Change on the Biogeography of Three Amnesic Shellfish Toxin Producing Diatom Species

Borges

Lopes

Santos

et al. 2022

Toxins

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Harmful algal blooms (HABs) are considered one of the main risks for marine ecosystems and human health worldwide. Climate change is projected to induce significant changes in species geographic distribution, and, in this sense, it is paramount to accurately predict how it will affect toxin-producing microalgae. In this context, the present study was intended to project the potential biogeographical changes in habitat suitability and occurrence distribution of three key amnesic shellfish toxin (AST)—producing diatom species (i.e., Pseudo-nitzschia australis, P. seriata, and P. fraudulenta) under four different climate change scenarios (i.e., RCP-2.6, 4.5, 6.0, and 8.5) up to 2050 and 2100. For this purpose, we applied species distribution models (SDMs) using four abiotic predictors (i.e., sea surface temperature, salinity, current velocity, and bathymetry) in a MaxEnt framework. Overall, considerable contraction and potential extirpation were projected for all species at lower latitudes together with projected poleward expansions into higher latitudes, mainly in the northern hemisphere. The present study aims to contribute to the knowledge on the impacts of climate change on the biogeography of toxin-producing microalgae species while at the same time advising the correct environmental management of coastal habitats and ecosystems.

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The Phycotoxin Domoic Acid as a Potential Factor for Oxidative Alterations Enhanced by Climate Change

Cited by 8 publications

References 54 publications

Domoic Acid Oxidative Effects on the Microalgae Phaeodactylum tricornutum

Domoic Acid Oxidative Effects on the Microalgae Phaeodactylum tricornutum

Transcriptional Response in the Digestive Gland of the King Scallop (Pecten maximus) After the Injection of Domoic Acid

Impacts of Climate Change on the Biogeography of Three Amnesic Shellfish Toxin Producing Diatom Species

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