The physical features -size and granularity- of solid materials are strongly affected by trituration in lactose, before turning them into homeopathic solutions

Kalliantas, D.; Kassalia, M.E.; Georgiadou, Anna; Karagianni, Ch. S.

doi:10.1016/j.msec.2018.07.038

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…Since alpha-lactose is soluble in water, only the insoluble particles of the origin material remain to be measured. So, we used the DLS-Zetasizer Nano with measuring range 0,6 nm-6μm and the result is shown in Figure 3f, something which was demonstrated in a previous work [29]. Comparing alpha-lactose granulation to ethanol 99,8% solution (Figure 3e) with our results we find no relation between our findings and its existence.…”

Section: Discussionsupporting

confidence: 65%

“…The aim of the mathematical approach is to show that the source materials or liquid stock particles in ultra-high diluted succussed solution products have dimension as an equation-power of the measuring unit l in all potencies, so, they are always present. As it has been shown, in our previous work, the physical features-size and granularity-of solid materials which are using as source materials are strongly affected by trituration in lactose, before turning them into ultra-high diluted succussed medicinal products [ 29 ]. During trituration a gradual decrease in grain size of the source materials approaching the micro and nanoscale finally occurs and is related not to the type of material but to its original grain size before grinding.…”

Section: Discussionmentioning

confidence: 99%

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Micro-nano particulate compositions of Hypericum perforatum L in ultra high diluted succussed solution medicinal products

Kalliantas¹,

Kallianta

Kordatos³

et al. 2021

Heliyon

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The fact that many patients all over the world use homeopathic ultra high diluted succussed medicinal products, makes very interesting an explanation about the structure of them since until now only unconfirmed hypotheses are made. The present study focuses on the still unanswered questions about what happens with the chemical composition and the physicochemical properties of these products using Hypericum Perforatum L as a representative paradigm. All samples were prepared according to manufacturing procedures described mainly in S. Hahnemann's "Organon" and were examined by SEM, XRD, FTIR, DLS micro Mastersizer, DLS nano Zetasizer, UV-Vis and TEM. Measurements of electrical conductivity and pH were effectuated by the appropriate devices. During trituration of source material in alpha-lactose monohydrate some functional chemical groups present in source material disappeared and some others new ones came in view at the end of the process. A differentiation upon physicochemical properties between the source material and final triturating product was viewed, as well as micro-nanoparticles in colloidal form in all potencies derived trituration or extraction origin were present. The findings showed that the whole preparation process leads to the creation of micro nanoparticles something that for solid origin these products are created by trituration and for extract origin products these nanoparticles exist from the beginning.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Micro-nano particulate compositions of Hypericum perforatum L in ultra high diluted succussed solution medicinal products

Kalliantas¹,

Kallianta

Kordatos³

et al. 2021

Heliyon

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“…They present reverse self-similarity properties with almost all known diseases. Also, as we have demonstrated in our previous work, the physical featuressize and granularityof solid raw starting materials to prepare these ultra high diluted succussed solution products are strongly affected by trituration in lactose, before turning them into homeopathic solutions, and in the final triturated step the materials are transformed into micro/nano scale (Kalliantas et al 2018;Kalliantas et al 2017). The validation of the Hippocratic idea that a substance which may cause symptoms to a healthy person can also cure these symptoms was carried out for the first time by S. Hahnemann with Cortex Peruvian fever tree bark.…”

Section: Resultsmentioning

confidence: 79%

RETRACTED ARTICLE: Homeopathy combat against coronavirus disease (Covid-19)

Kalliantas

Kallianta

Karagianni³

2020

J Public Health (Berl.)

Self Cite

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Aim Today, humanity is living through the third serious coronavirus outbreak in less than 20 years, following SARS in 2002-2003 and MERS in 2012. While the final cost on human lives and world economy remains unpredictable, the timely identification of a suitable treatment and the development of an effective vaccine remain a significant challenge and will still require time. The aim of this study is to show that the global collective effort to control the coronavirus pandemic (Covid 19) should also consider alternative therapeutic methods, and national health systems should quickly endorse the validity of proven homeopathic treatments in this war against coronavirus disease. Subject and methods With the help of mathematics, we will show that the fundamental therapeutic law on which homeopathy is founded can be proved. Results The mathematical proof of the law of similarity justifies perfectly the use of ultra-high diluted succussed solution products as major tools in the daily practices of homeopathy. Conclusion It is now time to end prejudice and adopt in this fight against Covid-19 alternative therapeutic techniques and practices that historically have proven effective in corresponding situations.

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“…Several works [12][13][14] confirmed the presence of absorption spectral peaks in the 0.1 to 2.6 THz range at frequencies of 0.53 THz (a peak presumably corresponding to the hindered rotational mode of the α-lactose molecule in the crystal), 1.38, 1.82, and 2.56 THz. By using the THz spectroscopic analysis, it is also possible to observe structural changes in a substance in the absorption spectrum at different temperatures [15]. So far, studies on the spectral analysis of α-lactose monohydrate fluidized with dilutions of pharmaceutical ingredients in the far-IR range were not performed.…”

Section: Introductionmentioning

confidence: 99%

Optical Properties of Crystalline Lactose Fluidized with Dilutions of Various Substances in the Terahertz Frequency Range

et al. 2021

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Lactose is a commonly used component of pharmaceutical medications in tablet form. It was previously shown that lactose changes conformationally after saturation in fluidized beds with active pharmaceutical ingredients obtained by repeated dilution of antibodies to interferon-gamma in combination with an external intensive vibration treatment. Moreover, it was revealed that these solutions are self-organized dispersed systems in which nano-objects are formed. Their biological activity and mechanism of action were previously established as well. The current work was dedicated to investigating the optical properties of fluidized lactose powders in the terahertz frequency range. Spectral analyses of powders of crystalline lactose saturated in fluidized beds with a diluted solution of either glycine buffer, antibodies to interferon-gamma, or water were carried out, intact lactose served as a control. All powders were tableted before testing. In the course of the study, the macroscopic parameters of the tablets were established, at which they had a stable shape and their THz optical properties had no parasitic diffraction losses. These tablets were analyzed using terahertz time-domain spectroscopy in the frequency range of 0.2–2.6 THz. The differentiation between the spectra was conducted using a principal component analysis. The differences between intact lactose and the lactose saturated with any of studied solutions were demonstrated. Additionally, lactose saturated with solutions of multiple dilutions of a substance (antibodies or glycine buffer) differed not only from intact lactose, but also from lactose saturated with a diluted solution of water. Moreover, discrimination of lactose formulations saturated with different substances (antibodies or glycine buffer) was also possible. Additionally, intact lactose differed from lactose saturated with diluted water. The methods reported could be useful for the quality control of the medications based on the technology of repeated dilution of an original substance.

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The physical features -size and granularity- of solid materials are strongly affected by trituration in lactose, before turning them into homeopathic solutions

Cited by 6 publications

References 24 publications

Micro-nano particulate compositions of Hypericum perforatum L in ultra high diluted succussed solution medicinal products

Micro-nano particulate compositions of Hypericum perforatum L in ultra high diluted succussed solution medicinal products

RETRACTED ARTICLE: Homeopathy combat against coronavirus disease (Covid-19)

Optical Properties of Crystalline Lactose Fluidized with Dilutions of Various Substances in the Terahertz Frequency Range

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