The physiologic properties and therapeutic potential of coherin

Hiatt, Robert B.; Goodman, Irving

doi:10.1016/0002-9610(79)90015-1

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2012

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Cited by 8 publications

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“…Coherin™, a complex of peptides isolated from the bovine or porcine posterior pituitary gland, was discovered by Hiatt and Goodman 1,2 . Since then, these investigators and others have studied the physiologic properties and therapeutic potential of Coherin™ primarily for the treatment of gastrointestinal diseases 3–6 . Coherin™ has been investigated for its effect on Crohn’s disease, colitis, regional ileitis, postgastric surgery physiologic obstruction, and cholecystectomy 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Coherin™ on intraocular pressure, pupil size and heart rate in the glaucomatous Beagle: a pilot study

MacKay

Gelatt

2012

Veterinary Ophthalmology

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Of seven different concentrations, 2% and 0.248% Coherin™ produced significant declines in IOP in the glaucomatous beagle in single-dose studies when compared to both untreated control and placebo-treated eyes. One percent Coherin™ solution produced significant IOP decreases compared with the placebo-treated eye but not the untreated control eyes. No local ocular irritation, PS and HR changes were observed in Coherin™-treated eyes. This pilot study suggests that topical Coherin™ has potential as an ocular hypotensive agent.

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Section: Introductionmentioning

confidence: 99%