The phytochemical composition, metabolites, bioavailability and in vivo antioxidant activity of Tetrastigma hemsleyanum leaves in rats

Sun, Yong; Tsao, Rong; Chen, Fang; Li, Hongyan; Wang, Jiawen; Peng, Han; Zhang, Ke; Deng, Zeyuan

doi:10.1016/j.jff.2017.01.004

Cited by 45 publications

(50 citation statements)

References 31 publications

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“…Peaks appearing in chromatograms of both propolis extracts and plasma or urine sample groups, but not in the propolis internal extracts, are regarded as absorbed components (precursor), and the peaks appeared only in the chromatograms of propolis plasma or urine samples but not in those of blank plasma and urine samples were considered as metabolites (Sun et al., ). It was worth noting that UE rat urine and plasma had the most metabolites.…”

Section: Resultsmentioning

confidence: 99%

The Phenolic Compounds, Metabolites, and Antioxidant Activity of Propolis Extracted by Ultrasound‐Assisted Method

Yuan

Zheng

Linhui

et al. 2019

Journal of Food Science

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The influences of ultrasound-assisted, pharmacopeia, and supercritical fluid extraction methods on bioactive compounds and biological activities of propolis were evaluated. Results showed that propolis extracted by ultrasoundassisted method contained more phenolic compounds, and showed the highest total phenolic content (245.84 ± 6.41 mg GAE/g DW), total flavonoids content (198.82 ± 5.74 mg RE/g DW), and stronger in vitro antioxidant activity (DPPH·: 1.03 ± 0.04 mmol Trolox/g DW, ABTS+·: 2.19 ± 0.05 mmol Trolox/g DW, and FRAP: 1.48 ± 0.12 mmol FeSO 4 /g DW) than those of pharmacopoeia and supercritical fluid methods. A total of 36 phenolic compounds were identified in propolis. Among them, quercetin, quercetin-3-methyl-ether, kaempferol, isorhamnetin, luteolin-methyl-ether, and quercetin-7-methyl-ether could only be found in ultrasound-assisted and pharmacopoeia methods. Moreover, the phenolic compounds had the similar metabolic pathways in rats and were mainly metabolized by sulfation and glucuronidation pathways. Additionally, ultrasonic-treated propolis have good in vivo antioxidant activity and could repair D-galactoseinduced oxidative damage in rats. Therefore, ultrasound-assisted method could replace pharmacopeia method to be considered as bioactive compounds extraction from propolis, taking into consideration of yield, short extraction time, and high antioxidant activity.

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Section: Resultsmentioning

confidence: 99%

The Phenolic Compounds, Metabolites, and Antioxidant Activity of Propolis Extracted by Ultrasound‐Assisted Method

Yuan

Zheng

Linhui

et al. 2019

Journal of Food Science

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“…Absorption of catechins is believed to occur through the small intestine because bacterial degradation within the colon is hypothesized to break down the flavonoids into smaller phenolic acids including hydroxyphenyl acetic acid, hydroxyphenylpropionic acid, phenylpropionic acid, and hydroxyphenylvaleric acid (Déprez et al, 2000;Rechner et al, 2004). Catechins are metabolized and circulated as sulfated, methylated, or glucuronidated derivatives, as well as various phenolic catabolites absorbed in the colon (Lee et al, 2002;Meng et al, 2002;Piskula and Terao, 1998;Sun et al, 2017;Shahidi and Peng, 2018).…”

Section: Flavan-3-olsmentioning

confidence: 99%

Phenolic compounds in agri-food by-products, their bioavailability and health effects

Shahidi¹,

Varatharajan²,

Oh³

et al. 2019

Journal of Food Bioactives

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111

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Phenolic compounds constitute a large and diverse group of secondary metabolites derived from phenylalanine and tyrosine and are widely distributed throughout the plant kingdom. They could be divided into different classes such as simple phenol, phenyl acetic acid, hydroxybenzoic acid, hydroxycinnamic acid, and other phenylpropanoids as well as condensed tannins (proanthocyanidins) and hydrolysable tannins, among others, depending on their basic carbon skeleton structure. Phenolic compounds in plant-based foods have been suggested to have a number of beneficial health effects including prevention of cancer, cardiovascular disease, diabetes, immune disorders, neurogenerative disease and others. These properties are largely attributable to the antioxidant activity of the phenolic compounds as well as other mechanisms of action. Therefore, nutraceuticals of plant origin may evolve to be considered a vital aspect of dietary-disease preventive food components. Agri-food industries generate substantial quantities of phenolic rich by-products, which could serve as an attractive and commercially viable source of nutraceuticals. This contribution mainly summarizes the occurrence of phenolic compounds and some other bioactives in various Agri-food by-products, their bioavailability and health benefits.

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“…Sun et al . suggested that there was no single antioxidant assay method that can represent the in vivo biological system, so the intrinsic phenolic compounds together with their metabolites, may collectively, or even synergistically act as antioxidants in rats (Sun et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…The metabolomics study of CAD from GPM leaves extract showed that metabolites including caffeic aldehyde, quinic acid, (Sun et al, 2017).…”

Section: Analysis Of Urine Metabolites In Vivomentioning

confidence: 99%

In vitro simulated digestion and in vivo metabolism of chlorogenic acid dimer from Gynura procumbens (Lour.) Merr.: Enhanced antioxidant activity and different metabolites of blood and urine

Qin

et al. 2018

J Food Biochem

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Gynura procumbens (Lour.) Merr. is an evergreen edible vine in southern China. The antioxidant activity and metabolites of chlorogenic acid dimer from Gynura procumbens (Lour.) Merr. were evaluated by the model of in vitro digestion and in vivo metabolomics approach, respectively. Moreover, metabolites of chlorogenic acid dimer in blood and urine of Sprague‐Dawley rats were determined by HPLC‐ESI‐QTOF‐MS/MS. In vitro digestion results suggested the antioxidant activity of the purified chlorogenic acid dimer was significantly enhanced after simulated digestion. Meanwhile, in vivo metabolism results showed that 7 and 20 new metabolites were observed in blood and urine, respectively, suggesting that hydrolysis along with methylation, glucuronidation and other reactions may all happen when the chlorogenic acid dimer entered the digestive and metabolic systems, which inducing and exhibiting various biological activities through metabolism. Practical applications Gynura procumbens (Lour.) Merr. (GPM) is an evergreen edible vine with the effects of anticancer, anti‐inflammatory, antiviral, depressurization, and antioxidation. As a health care vegetable, it is not usually eaten in daily life. Our current study shows that chlorogenic acid dimer extracted from GPM has a significant enhanced antioxidant ability after gastro‐intestinal digestion in vitro, and their metabolites in vivo of urine is far more than that of blood, which may indicate that the chlorogenic acid dimer can be fully absorbed and decomposed through the gastro‐intestinal digestion and metabolism. Thus, GPM could be used as a functional food ingredient for antioxidant enhancement to promote the economic value. The research also provides theoretical data for the intensive processing and utilization of GPM, as well as for the relative research on digestion and metabolism of edible plants.

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The phytochemical composition, metabolites, bioavailability and in vivo antioxidant activity of Tetrastigma hemsleyanum leaves in rats

Cited by 45 publications

References 31 publications

The Phenolic Compounds, Metabolites, and Antioxidant Activity of Propolis Extracted by Ultrasound‐Assisted Method

The Phenolic Compounds, Metabolites, and Antioxidant Activity of Propolis Extracted by Ultrasound‐Assisted Method

Phenolic compounds in agri-food by-products, their bioavailability and health effects

In vitro simulated digestion and in vivo metabolism of chlorogenic acid dimer from Gynura procumbens (Lour.) Merr.: Enhanced antioxidant activity and different metabolites of blood and urine

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