The Pilot Trial on Intraoperative Radiotherapy with Electrons (ELIOT): Update on the Results

Luini, Alberto; Orecchia, Roberto; Gatti, Giovanna; Intra, Mattia; Ciocca, Mario; Galimberti, Viviana; Veronesi, Paolo; Santos, Gabriela R.; Gilardi, Daniela; Veronesi, Umberto

doi:10.1007/s10549-005-3782-1

Cited by 60 publications

(37 citation statements)

References 16 publications

(15 reference statements)

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“…More recently, IORT with electrons has been used as the sole form of radiation treatment for patients with early breast cancer. Several studies on this topic have been published by the group of the European Institute of Oncology in Milan, Italy [11,18,32,33]. In the first pilot study, Veronesi et al reported that a single fraction of 21 Gy prescribed at the 90% isodose (23.3 Gy at Dmax) can be safely applied intraoperatively and is biologically equivalent to a 60-Gy dose delivered by EBRT in 30 fractions [32].…”

Section: Discussionmentioning

confidence: 99%

“…In the first pilot study, Veronesi et al reported that a single fraction of 21 Gy prescribed at the 90% isodose (23.3 Gy at Dmax) can be safely applied intraoperatively and is biologically equivalent to a 60-Gy dose delivered by EBRT in 30 fractions [32]. The last published study analyzed 590 patients treated by a single 21-Gy dose after breast-conserving surgery [18]. After a median follow-up of 24 months, three patients developed a local relapse, three patients ipsilateral carcinoma in another quadrant of the breast, five patients contralateral breast cancer, and 13 patients distant metastases without local relapse.…”

Section: Discussionmentioning

confidence: 99%

“…According to this important observation, irradiation of the whole mammary gland could be avoided in select patients and adjuvant radiotherapy could be limited to the sterilization of residual cancer in the immediate vicinity of the tumor bed. The feasibility of partial-breast irradiation (PBI) has been investigated by several authors, using different techniques, such as brachytherapy with multicatheter [1,2,4,13,15,20,22,23,34,36] or single-catheter implants [7,12,37], three-dimensional conformal external-beam radiotherapy (EBRT) [3,9,35], or intraoperative radiotherapy (IORT) with either electrons [11,18,32,33] or a low-kW X-ray source [14,29,30]. The main advantages of IORT are the possibility of a better localization of the dose in the area at higher risk of local recurrences and the avoidance of 5-6 weeks of EBRT.…”

Section: Introductionmentioning

confidence: 99%

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Full-Dose Intraoperative Radiotherapy with Electrons in Breast Cancer

et al. 2006

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IORT in breast carcinoma is still an experimental treatment option for select patients with breast cancer and its application should be restricted to prospective trials. Although preliminary data on local control are encouraging, a longer follow-up is needed to confirm the efficacy of IORT in breast cancer and to exclude that severe late complications compromise the cosmetic results or modify the radiologic breast appearance during follow-up increasing the need for additional investigations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Full-Dose Intraoperative Radiotherapy with Electrons in Breast Cancer

et al. 2006

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“…A cirurgia conservadora de mama, a biópsia do linfonodo sentinela e a radioterapia intra-operatória associada à cirurgia conservadora 33 são avanços que podem contribuir para uma melhor percepção da QV. Intuitivamente, acredita-se que essas abordagens relacionem-se à melhor QV.…”

Section: Cirurgiaunclassified

Qualidade de vida de mulheres com câncer de mama

Conde¹,

Pinto‐Neto²,

Júnior³

et al. 2006

Rev. Bras. Ginecol. Obstet.

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RESUMOO câncer de mama é uma das neoplasias mais comuns entre mulheres. O diagnóstico e a terapia antineoplásica determinam repercussões sociais, econômicas, físicas, emocionais/psicológicas e sexuais. Os principais parâmetros empregados na avaliação dos resultados da terapia antineoplásica são a sobrevida livre de doença e a sobrevida global. Mais recentemente, a qualidade de vida (QV) tem sido considerada mais um desses parâmetros. Não existe consenso quanto à definição de QV. Porém, a maioria das definições contempla os aspectos multidimensional e subjetivo da QV. A identificação dos fatores relacionados à QV e a compreensão da forma como esses fatores contribuem para a percepção da QV são motivos de discussão, uma vez que o conceito de QV está diretamente relacionado ao contexto sociocultural em que o indivíduo está inserido. A idade ao diagnóstico, uso de quimioterapia, tipo de cirurgia, sintomas climatéricos, relacionamento conjugal e sexualidade são alguns fatores associados à QV de mulheres com câncer de mama. A QV associada a diferentes terapias antineoplásicas pode auxiliar pacientes e médicos na escolha da melhor modalidade terapêutica. Nesse sentido, o presente artigo revisa diversos aspectos da QV de mulheres com câncer de mama, apresentando e discutindo o estado atual do conhecimento sobre o tema. PALAVRAS-CHAVE: Neoplasias mamárias; Qualidade de vida; Sintomas climatéricos ABSTRACTBreast cancer is one of the most common malignancies among women. Its diagnosis and treatment have social, economic, physical, emotional/psychological and sexual repercussions. The main parameters used to assess the results of anticancer therapy are disease-free survival and overall survival. More recently, quality of life (QOL) has been considered an additional parameter. No consensus exists about the definition of QOL. However, most definitions take into account multidimensional and subjective aspects of QOL. The identification of factors related to QOL and comprehension of how these factors contribute to the perception of QOL are reasons for debate, since the concept of QOL is directly related to the social and cultural context in which the individual is inserted. Age at diagnosis, chemotherapy, type of surgery, climacteric symptoms, relationship between the couple, and sexuality are several factors associated with QOL in women with breast cancer. QOL associated with different antineoplastic therapies may help patients and physicians choose the best therapeutic modality. Towards this end, the current article addresses various aspects of QOL of breast cancer women, and presents the state-ofthe-art knowledge on the topic. KEYWORDS:

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“…Dabei erhielten 10 Patientinnen eine einmalige Dosis von 10 Gy und 7 Patientinnen von 15 Gy, der anschließend eine perkutane Brustbestrahlung mit in der Regel 50 Gy in jeweils 2 Gy-Fraktionen folgte. Die restlichen 84 Fälle wurden alleinig intraoperativ mit Dosen von 17, 19 oder 21 Gy bestrahlt [13].…”

Section: Introductionunclassified

Intraoperative Strahlentherapie beim Mammakarzinom

et al. 2009

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Intraoperative Strahlentherapie beim MammakarzinomLeitthema Durch verbesserte diagnostische Verfahren und das Mammographiescreening werden Mammakarzinome zunehmend in frühen Stadien festgestellt. In diesem Zusammenhang wird auch die Ganzbrustbestrahlung nach brusterhaltender Operation kritisch hinterfragt. Da 90% der Lokalrezidive in unmittelbarer Nähe zum ursprünglichen Primärtumor auftreten, zeigt sich ein zunehmendes Interesse an Teilbrustbestrahlungen als Boost oder als Ersatz für die Bestrahlung der gesamten Restbrust. Dennoch muss die alleinige Teilbrustbestrahlung außerhalb von Studien weiterhin als experimentelle Therapie angesehen werden.

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The Pilot Trial on Intraoperative Radiotherapy with Electrons (ELIOT): Update on the Results

Abstract: The first group of patients treated with ELIOT in the phase I-II trial are confirming the good impact of the procedure in terms of tolerance and quality of life.

Cited by 60 publications

References 16 publications

Full-Dose Intraoperative Radiotherapy with Electrons in Breast Cancer

Full-Dose Intraoperative Radiotherapy with Electrons in Breast Cancer

Qualidade de vida de mulheres com câncer de mama

Intraoperative Strahlentherapie beim Mammakarzinom

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