The Plasma Membrane Ca2+-ATPase, a Molecular Target for Tau-induced Cytosolic Calcium Dysregulation

Berrocal, María Cruz; Mata, Ana M.

doi:10.1016/j.neuroscience.2022.04.016

Cited by 7 publications

(1 citation statement)

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“…PMCA is balancing as an outflux unit. In AD PMCA could be inhibited by tau [ 56 ]. SERCA-like formulation because of its similar process, the mathematical expression of PMCA flux is given as follows [ 54 ]: …”

Section: Mathematical Model Formulationmentioning

confidence: 99%

To study the effect of ER flux with buffer on the neuronal calcium

Vatsal,

Jha,

Singh

2023

Eur. Phys. J. Plus

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Calcium signaling is decisive for cellular functions. This calcium random walk stipulates neuronal functions. Calcium concentration could provoke gene transcription, apoptosis, neuronal plasticity, etc. A malformation in calcium could change the neuron’s intracellular behavior. Calcium concentration balancing is a complex cellular mechanism. This occurrence can be handled with the Caputo fractional reaction–diffusion equation. In this mathematical modeling, we have included the STIM-Orai mechanism and Endoplasmic Reticulum (ER) flux, Inositol Triphosphate Receptor (IPR), SERCA, plasma membrane flux, voltage-gated calcium entry, and different buffer interactions. A hybrid integral transform and Green’s function approach were taken to solve the initial boundary problem. A closed-form solution of a Mittag-Leffler family function plotted using MATLAB software. Different parameters impact changes in the spatiotemporal behavior of the calcium concentration. Specific roles of organelles involved in Alzheimer’s disease-affected neurons are computed. Ethylene glycol tetraacetic acid (EGTA), 1,2-bis(o-aminophenoxy)ethane N,N,N,N-tetraacetic acid (BAPTA), and S100B protein effects are also observed. In all simulations, we can say S100B and the STIM-Orai effect cannot be neglected. This model lights up the different approaches for calcium signaling pathway simulation. As a consequence, we determine that a generalized reaction–diffusion approach is a better fit realistic model.

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Section: Mathematical Model Formulationmentioning

confidence: 99%