The plasma membrane transformation facilitates pregnancy in both reptiles and mammals

Murphy, Christopher R.; Hosie, Margot J.; Thompson, Michael B.

doi:10.1016/s1095-6433(00)00274-9

Cited by 34 publications

(46 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These changes, termed the ''plasma membrane transformation, '' include a loss of microvilli resulting in a £attened epithelial surface. After similar changes were observed during early pregnancy in the viviparous skinks Eulamprus tympanum and Niveoscincus metallicus, Murphy et al (2000) suggested that the plasma membrane transformation may also be common to viviparous lizards.…”

Section: Placentationmentioning

confidence: 67%

See 1 more Smart Citation

The reptilian oviduct: a review of structure and function and directions for future research

2002

View full text Add to dashboard Cite

The reptilian oviduct is a complex organ with a variety of functions (albumen production, eggshell production, placentation, oviposition or parturition, and sperm storage), depending on the parity mode of the species in question. These functions are under complex physiological control, the details of which are far from understood. The aims of this review are to summarise the information available concerning the structure and functions of the reptilian oviduct and to highlight areas in particular need of further research.

show abstract

Section: Placentationmentioning

confidence: 67%

“…In the initial stages of placentation in eutherian mammals, a series of changes in the plasma membrane of uterine epithelia occurs in preparation for implantation of the blastocyst (Murphy et al, 2000). These changes, termed the ''plasma membrane transformation, '' include a loss of microvilli resulting in a £attened epithelial surface.…”

Section: Placentationmentioning

confidence: 99%

The reptilian oviduct: a review of structure and function and directions for future research

2002

View full text Add to dashboard Cite

show abstract

“…If specialized placental structures transport water, gases, and nutrients between mothers and offspring, then adhesion mechanisms are necessary to keep the uterine and embryonic components of these structures adjacent throughout development. Uterine plasma membrane transformations similar to those that facilitate implantation in the rat, including flattening of the apical plasma membrane of uterine epithelial cells, occur during pregnancy in the skink genera Niveoscincus and Eulamprus (Murphy et al 2000, Hosie et al 2003. Throughout pregnancy, uterine tissues opposite the yolk sac of viviparous skinks of the genera Pseudemoia, but not Saiphos, exhibit decreases in desmosome expression (Biazik et al 2010a).…”

Section: Implantation and Placentationmentioning

confidence: 99%

The evolution of viviparity: molecular and genomic data from squamate reptiles advance understanding of live birth in amniotes

2014

Self Cite

View full text Add to dashboard Cite

Squamate reptiles (lizards and snakes) are an ideal model system for testing hypotheses regarding the evolution of viviparity (live birth) in amniote vertebrates. Viviparity has evolved over 100 times in squamates, resulting in major changes in reproductive physiology. At a minimum, all viviparous squamates exhibit placentae formed by the appositions of maternal and embryonic tissues, which are homologous in origin with the tissues that form the placenta in therian mammals. These placentae facilitate adhesion of the conceptus to the uterus as well as exchange of oxygen, carbon dioxide, water, sodium, and calcium. However, most viviparous squamates continue to rely on yolk for nearly all of their organic nutrition. In contrast, some species, which rely on the placenta for at least a portion of organic nutrition, exhibit complex placental specializations associated with the transport of amino acids and fatty acids. Some viviparous squamates also exhibit reduced immunocompetence during pregnancy, which could be the result of immunosuppression to protect developing embryos. Recent molecular studies using both candidate-gene and next-generation sequencing approaches have suggested that at least some of the genes and gene families underlying these phenomena play similar roles in the uterus and placenta of viviparous mammals and squamates. Therefore, studies of the evolution of viviparity in squamates should inform hypotheses of the evolution of viviparity in all amniotes, including mammals.Reproduction (2014) 147 R15-R26

show abstract

“…In the rhesus monkey, Enders et al [34] showed loss of microvilli and other flattened membrane areas on uterine epithelial cell surfaces at attachment and in humans several workers have pointed out similarities between the behaviour of rodent and human uterine epithelial cell apical plasmalemmas during early pregnancy [35][36][37][38][39] as we shall examine in more detail later. As if to highlight the commonality of these events, in a very different class of animals, apical plasma membrane flattening during early pregnancy has now been reported in viviparous lizards [40].…”

Section: The Apical Plasma Membrane In Other Animalsmentioning

confidence: 99%

Uterine receptivity and the plasma membrane transformation

2004

Self Cite

View full text Add to dashboard Cite

This review begins with a brief commentary on the diversity of placentation mechanisms, and then goes on to examine the extensive alterations which occur in the plasma membrane of uterine epithelial cells during early pregnancy across species. Ultrastructural, biochemical and more general morphological data reveal that strikingly common phenomena occur in this plasma membrane during early pregnancy despite the diversity of placental types-from epitheliochorial to hemochorial, which ultimately form in different species. To encapsulate the concept that common morphological and molecular alterations occur across species, that they are found basolaterally as well as apically, and that moreover they are an ongoing process during much of early pregnancy, not just an event at the time attachment, the term 'plasma membrane transformation' is suggested which also emphasises that alterations in this plasma membrane during early pregnancy are key to uterine receptivity. INTRODUCTIONContact between the plasma membrane of uterine epithelial cells and that of the trophoblast is a common beginning to implantation in most species studied so far. This is perhaps not surprising since uterine epithelial cells are the first site of contact between maternal and foetal tissue at the beginning of blastocyst attachment and implantation. The similarities in these early events of the uterine response during early pregnancy and placentation however, go further than mere contact between opposing surfaces. A now considerable body of evidence indicates that the behaviour of the plasma membrane of the uterine epithelial cells during early pregnancy has many common aspects across species ranging from viviparous lizards to human beings and that moreover, these similarities exist regardless of the placental type which ultimately develops. This review pays special attention to events at the cellular level in uterine epithelial cells and to the plasma membrane in particular, but does so within the wider context of uterine receptivity for implantation across species.

show abstract

The plasma membrane transformation facilitates pregnancy in both reptiles and mammals

Cited by 34 publications

References 55 publications

The reptilian oviduct: a review of structure and function and directions for future research

The reptilian oviduct: a review of structure and function and directions for future research

The evolution of viviparity: molecular and genomic data from squamate reptiles advance understanding of live birth in amniotes

Uterine receptivity and the plasma membrane transformation

Contact Info

Product

Resources

About