The platelet-to-lymphocyte ratio as a predictor of all-cause mortality in patients with coronary artery disease undergoing elective percutaneous coronary intervention and stent implantation

Osadnik, Tadeusz; Wasilewski, Jarosław; Lekston, Andrzej; Strzelczyk, Joanna Katarzyna; Klinke, Anna; Gonera, Małgorzata; Gawlita, Marcin; Reguła, Rafał; Bujak, Kamil; Szyguła‐Jurkiewicz, Bożena; Wiczkowski, Andrzej; Poloński, Lech

doi:10.1016/j.jsha.2015.02.004

Cited by 34 publications

(26 citation statements)

References 41 publications

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“…Similar to the present study, some studies show that the co-occurrence of CAE and PLR indicates a significance in univariate analysis; however, the significance disappears in multivariate and adjusted analyses [30].…”

Section: Platelet-to-lymphocyte Ratio (Plr)supporting

confidence: 89%

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Hematological predictors and clinical outcomes in cardiac surgery

et al. 2016

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Section: Platelet-to-lymphocyte Ratio (Plr)supporting

confidence: 89%

“…Compared to the other hematological parameters, PLR appears to be a poor marker in the prediction of cardiac surgery outcomes [30].…”

Section: Platelet-to-lymphocyte Ratio (Plr)mentioning

confidence: 97%

Hematological predictors and clinical outcomes in cardiac surgery

et al. 2016

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“…Considering the number and the heterogeneity of RCC prognostic factors and the interactions between renal cell carcinoma and immune cells, searching for widely available and reliable inflammatory biomarkers seems essential [7,9]. Up to now, numerous studies have reported that some non-specific indicators derived from complete blood count (CBC) give added prognostic value in the assessment of various diseases, including renal cell carcinoma [10][11][12][13][14][15][16]. Amongst the most promising indices that are based on absolute values of circulating inflammatory cells, platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), derived neutrophil-lymphocyte ratio (dNLR) and lymphocyte-monocyte ratio (LMR) are being particularly deeply investigated.…”

Section: Introductionmentioning

confidence: 99%

Novel hematological biomarkers predict survival in renal cell carcinoma patients treated with nephrectomy

Rajwa¹,

Życzkowski²,

Paradysz³

et al. 2020

aoms

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Introduction The association between novel blood-based inflammatory indices and patient survival has been reported with reference to various cancers. The aim of this study was to investigate the prognostic value of preoperative platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), derived neutrophil-lymphocyte ratio (dNLR) and lymphocyte-monocyte ratio (LMR) in patients with renal cell carcinoma (RCC) treated with nephrectomy. Material and methods From 2003 to 2012, 455 patients who underwent partial or radical nephrectomy for RCC were enrolled in the study. The study endpoints were overall survival (OS) and cancer-specific survival (CSS). Results The median follow-up was 70 months. Groups of patients with high levels of PLR, NLR and dNLR and a low level of LMR more often underwent radical nephrectomy, had a higher cancer stage in the TNM classification, and were more frequently diagnosed with tumor necrosis in histopathological examination. Both cancer-specific mortality and overall mortality were significantly higher in patients with high PLR, NLR and dNLR and low LMR. Multivariate analysis of CSS, adjusted for standard clinicopathological factors, identified only dNLR ( p = 0.006) as an independent prognostic factor. PLR ( p = 0.0002), dNLR ( p = 0.0003) and NLR ( p = 0.002), but not LMR ( p = 0.1), achieved prognostic significance in multivariable analysis regarding OS. Conclusions Only dNLR was an independent prognostic factor for CSS and OS. Nevertheless, our study indicates that all examined complete blood count-based biomarkers may be useful tools in managing RCC patients treated with a surgical approach.

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“…Azab et al [23] reported PLR > 176 is a significant independent predictor of long term mortality after NSTEMI. Osadnik et al [24] reported PLR as a predictor of all-cause mortality in patients with coronary artery disease undergoing elective percutaneous coronary intervention and stent implantation.…”

Section: Discussionmentioning

confidence: 99%

Platelet to lymphocyte ratio predicts all-cause mortality in patients with carotid arterial disease

Tek

Çetin

Diker

et al. 2019

Romanian Journal of Internal Medicine

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Background. Platelet to lymphocyte ratio (PLR) has been demonstrated as a risk and prognostic marker in many of cardiovascular diseases. A relationship between PLR and severity of carotid stenosis has been shown. The aim of our study was to investigate the relationship between PLR and all cause mortality in patients with carotid arterial disease.Methods. This retrospective study included 146 patients who had been performed selective carotid angiography. Carotid stenosis were graded by the North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria. Platelet to lymphocyte ratio was calculated as the ratio of platelets to lymphocytes. The end point of the study was all-cause mortality.Results. During median follow-up of 16 months (0-65 months) 15 (10.3%) patients suffered all-cause mortality. 50 patients (34.2%) underwent carotid endarterectomy and 69 patients (47.3%) had non-carotid cardiac surgery. 38 patients (26.02%) had cerebrovascular events (stroke/transient ischemic attack) at admission. NASCET grades were not different between survivors and nonsurvivors. Non-survivors had significantly lower hemoglobin (Hb) levels (12.7 ± 1.6 g/dL vs. 13.7 ± 1.7 g/dL, p = 0.031) and they were older than survivors (74.2 ± 8.4 years vs. 68.6 ± 8.5 years, p = 0.029). Non-survivors had significantly higher PLR values compared with survivors (190.3 ± 85.6 and 126.8 ± 53.8, p = 0.017). In multivariate analysis, only PLR predicted all-cause mortality in patients with carotid artery stenosis.Conclusion. In our study, higher PLR was associated with increased all-cause mortality.

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The platelet-to-lymphocyte ratio as a predictor of all-cause mortality in patients with coronary artery disease undergoing elective percutaneous coronary intervention and stent implantation

Abstract: PLR has potential predictive value in patients with SCAD, which has not been reported previously, but statistical significance disappears after adjusting for estimated glomerular filtration rate (eGFR) and hemoglobin levels as a potential confounding variable.

Cited by 34 publications

References 41 publications

Hematological predictors and clinical outcomes in cardiac surgery

Hematological predictors and clinical outcomes in cardiac surgery

Novel hematological biomarkers predict survival in renal cell carcinoma patients treated with nephrectomy

Platelet to lymphocyte ratio predicts all-cause mortality in patients with carotid arterial disease

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