The POLR2E rs3787016 polymorphism is associated with susceptibility to and prognosis of gastric cancer

Abstract

Long non-coding RNAs (lncRNAs) have been proposed as promising diagnostic and prognostic biomarkers for cancer. We investigated the associations of RNA polymerase II subunit E (POLR2E) rs3787016 polymorphism with the risk and prognosis of gastric cancer (GC). The study subjects included 368 GC patients who underwent surgical resection and 294 healthy volunteers, adjusted for age, gender, smoking status, alcohol status, and Helicobacter pylori infection status. The data was subjected to logistic regression analyses and revealed that the subjects carrying AA genotype of rs3787016 in POLR2E had a significant 1.85-1.98-fold increased risk of GC when compared with those carrying GG genotype (adjusted OR = 1.979, 95% CI = 1.198-3.267; p = 0.008) or those carrying AG/GG genotypes (adjusted OR = 1.847, 95% CI = 1.222-2.793; p = 0.004). For the GC patients, the AA genotype of rs3787016 was significantly correlated with poorly differentiated GC (p = 0.018), advanced TNM stage (p = 0.023), higher depth of invasion (p = 0.022), positive lymph node metastasis (p = 0.01), and worse overall survival (OS; p = 0.004). Multivariate analysis confirmed that the PO LR2E rs3787016 polymorphism is an independent prognostic factor for GC (HR = 1.668, 95% CI = 1.058-2.631; p = 0.028). Our cumulative results thus suggest that the presence of POLR2E rs3787016 polymorphism could serve as a genetic factor that affects the susceptibility to and the prognosis of GC.

Genetic Impact of HOTAIR, LINC00951, POLR2E and HULC Polymorphisms in Histopathological and Laboratory Prognostic Factors in Esophageal Cancer in the West: A Case-Control Study

“…SNP rs3787016 (A>G or its complementary T>C, C/T), localized in the fourth intron of the RNA polymerase II subunit E (POLR2E) lncRNA gene, has been implicated with cancer susceptibility either by predisposing for GC [49], breast and cervical cancer [50], or by protecting against ESCC [51] in Chinese populations. As no study to date has explored the molecular impact of POLR2E rs3787016 in histopathological and laboratory prognostic factors in EC/EAC in the west, we conducted a case-control study in a population of Greek/European ancestry.…”

MiRNA polymorphisms affect the prognosis of gastric cancer: insights from Xianyou, Fujian

“…Additionally, investigations have linked miR-34 rs4938723 and miR-195-5p to the prognosis of colorectal cancer (14,15). Moreover, research findings indicate that single nucleotide polymorphisms in miRNAs are correlated with the prognosis of various types of tumors (16)(17)(18)(19). While numerous studies have established associations between miRNA single nucleotide polymorphisms and the prognosis of various types of tumors, limited attention has been directed toward exploring the connection between miRNA single nucleotide polymorphisms and the prognosis of gastric cancer.…”