The polyamine and histamine metabolic interplay in cancer and chronic inflammation

Abstract

In mammalian cells, a polyamine/histamine metabolic interplay has been extensively proven; however, its ultimate effect on human health largely depends on the cell type and environment. Information on this topic is currently fragmented in the literature. In order to develop efficient intervention strategies, it will be necessary to establish an integrated and holistic view of the role of the polyamine/histamine metabolic interplay in each pathological state.

Lathyrus sativus diamine oxidase counteracts histamine‐induced cell proliferation, migration and pro‐angiogenic mediators release in human colon adenocarcinoma cell line Caco‐2

“…Moreover, because of its capability to breakdown histamine, LSAO has been proposed as an antiallergic enzyme to blunt food histaminosis and as a new tool reinforcing the treatment of inflammatory bowel diseases (Kennedy et al, ; Maintz & Novak, ; Missbichler et al, ). After all, a reduced activity and expression of endogenous DAO has been observed and correlated with the intestinal epithelial tumour growth already several years ago (Garcia‐Faroldi, Sanchez‐Jimenez, & Fajardo, ), even if it has been considered merely a bystander event during the complex network of tumour cell growth, and wrongly, set aside or even worst, forgotten. Because of the complexity and redundancy of different molecular pathways involved in colon cancer proliferation and angiogenesis, molecules capable of multi‐step targeting of different signalling tumorigenic pathways may be ideally required to develop anticancer strategy.…”

“…all, a reduced activity and expression of endogenous DAO has been observed and correlated with the intestinal epithelial tumour growth already several years ago(Garcia-Faroldi, Sanchez-Jimenez, & Fajardo, 2009), even if it has been considered merely a bystander event during the complex network of tumour cell growth, and wrongly, set aside or Lathyrus sativus-derived diamine oxidase (LSAO) inhibits histamine-induced pro-angiogenic proteins expression and release of nitrite and VEGF in Caco-2 cell line. (a) Immunoreactive bands referred to iNOS and VEGF-2R protein expression and (b,c) the relative densitometric analysis (arbitrary units normalized on the expression of the housekeeping protein GAPDH) showing the effect of LSAO (0.004-0.4 μM) in Caco-2 cells treated with histamine (1 μM).…”

Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target

“…The synthesis of these macromolecules requires conversion of arginine to ornithine through arginase activity. Then, ornithine is decarboxylated to produce putrescine, the first polyamine, in a reaction catalyzed by ornithine decarboxylase (ODC), and spermidine and spermine are synthetized using decarboxylated S‐adenosylmethionine (dcSAM) as an aminopropyl group donor . ODC was described as a proto‐oncogene as soon as 1992, and ODC levels are higher in tumors than in nonproliferating tissues .…”

Contents of biologically active polyamines in duck meat and giblets after slaughter and their changes during meat storage and cooking

“…Numerous roles of polyamines in health and disease have been recently reviewed (Dandrifosse, 2009;García-Faroldi, Sánchez-Jiménez, & Fajardo, 2009;Larqué, Sabater-Molina, & Zamora, 2007;Lefèvre, Palin, & Murphy, 2011;Moinard, Cynober, & de Bandt, 2005;Soda, 2010). Recent studies have suggested that reducing the level of polyamines in cells may help to slow down some cancer processes.…”