The Polyanalgesic Consensus Conference (PACC)®: Intrathecal Drug Delivery Guidance on Safety and Therapy Optimization When Treating Chronic Noncancer Pain

Deer, Timothy R.; Hayek, Salim M.; Grider, Jay S.; Hagedorn, Jonathan M.; McDowell, Gladstone C.; Kim, Philip; Dupoiron, Denis; Goel, Vasudha; Duarte, Rui; Pilitsis, Julie G.; Leong, Michael S.; De Andrés, Jose; Perruchoud, Christophe; Sukumaran, Harry; Abd-Elsayed, Alaa; Saulino, Michael; Patin, Dennis; Poree, Lawrence R.; Strand, Natalie; Gritsenko, Karina; Osborn, Jill A.; Dones, Ivano; Bux, Anjum; Shah, Jay M.; Lindsey, Brad L.; Shaw, Erik; Yaksh, Tony L.; Levy, Robert M.

doi:10.1016/j.neurom.2024.03.003

Neuromodulation: Technology at the Neural Interface

2024

DOI: 10.1016/j.neurom.2024.03.003

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The Polyanalgesic Consensus Conference (PACC)®: Intrathecal Drug Delivery Guidance on Safety and Therapy Optimization When Treating Chronic Noncancer Pain

Timothy R. Deer,

Salim M. Hayek,

Jay S. Grider

et al.

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Cited by 3 publications

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The diagnosis and treatment of neuropathic pain

Ahmadi,

Kuner,

Weidner

et al. 2024

Deutsches Ärzteblatt International

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The diagnosis and treatment of neuropathic pain

Ahmadi,

Kuner,

Weidner

et al. 2024

Deutsches Ärzteblatt International

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A perspective: neuraxial therapeutics in pain management: now and future

DeAndres,

Dickenson,

Hayek

et al. 2024

Front. Pain Res.

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The neuraxial delivery of drugs for the management of pain and other spinal pathologies is widely employed and is the subject of a large volume of ongoing research with several thousand papers appearing in the past 5 years alone on neuraxial delivery. Several learned texts have been recently published. A number of considerations have contributed to this widespread interest in the development of the use of neuraxial therapeutics to manage pain. In the following section, major topics relevant to spinal encoding and in the use of neuraxial therapeutics are considered by the Frontiers in Pain Research editors of the research topic: “Neuraxial Therapeutics in Pain Management: Now and Future”. This paper seeks to serve as a perspective to encourage the submission of manuscripts reflecting research in this exciting area.

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Multidimensional Analysis of Quality of Life in Patients with Chronic Non-Cancer Pain and Short- and Long-Term Intrathecal Analgesic Therapy

Sánchez-García,

Alcázar-Navarrete,

Cortiñas-Saenz

et al. 2024

Healthcare

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Background: Intrathecal drug delivery (IDD) is part of the fourth analgesic step. Evidence on the quality of life of patients with refractory chronic non-cancer pain (CNCP) using these devices and their long-term outcomes is scarce. This study aims to evaluate patients with IDD to assess their HRQoL. Additionally, the study seeks to understand the patients’ satisfaction with the treatment and changes in pain magnitude over time. Methods: Adult patients with CNCP and intrathecal drug delivery systems (IDDS) were included. The study population was divided into two groups: less than and more than 15 years of treatment. HRQoL was analyzed using validated questionnaires. Pain reduction was assessed using the visual analog scale (VAS), and treatment satisfaction was evaluated using the Patient Global Impression of Improvement scale. Results: The results indicate a poor HRQoL in IDD patients, with better scores in the group with ≥15 years of treatment. Pain reduction was similar in both groups, and patients reported a positive satisfaction level with the treatment. Conclusions: HRQoL in CNCP patients is severely affected. Long-term IDD patients have a similar or even better HRQoL in some respects compared to those with shorter follow-ups. IDD patients experienced pain reduction, with most feeling better or much better.

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The Polyanalgesic Consensus Conference (PACC)®: Intrathecal Drug Delivery Guidance on Safety and Therapy Optimization When Treating Chronic Noncancer Pain

Cited by 3 publications

References 227 publications

The diagnosis and treatment of neuropathic pain

The diagnosis and treatment of neuropathic pain

A perspective: neuraxial therapeutics in pain management: now and future

Multidimensional Analysis of Quality of Life in Patients with Chronic Non-Cancer Pain and Short- and Long-Term Intrathecal Analgesic Therapy

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