“…The renal tissues in Vil Cre Pkd2 f/f mice have elevated levels of active, nuclear, and total β-catenin (Ctnnb1) proteins ( Figure 1, A and B) and Axin2, c-Myc, and cyclin D1 proteins, which are produced by Wnt target genes ( Figure 1, C and D), compared with control mice (Pkd2 f/f ). These results are consistent with previous reports that PC2 deficiency increases Wnt/β-catenin signaling (27,37,66 Figure 2A). The loss of one Ctnnb1 allele rescued the elevated levels of active, nuclear, and total β-catenin found in the kidneys of Vil Cre Pkd2 f/f mice, bringing the levels down almost to those of control Pkd2 f/f mice, which did not have Vil-Cre ( Figure 1, A and B).…”