2018
DOI: 10.1016/j.jep.2018.06.034
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The polyherbal drug GGEx18 from Laminaria japonica, Rheum palmatum , and Ephedra sinica inhibits hepatic steatosis and fibroinflammtion in high-fat diet-induced obese mice

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Cited by 18 publications
(10 citation statements)
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“…2017; Lim et al. 2018) activities. A recent report related to the present study investigated the effect of E. sinica extracts on hyperlipidaemia in mice (Fan et al.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…2017; Lim et al. 2018) activities. A recent report related to the present study investigated the effect of E. sinica extracts on hyperlipidaemia in mice (Fan et al.…”
Section: Introductionmentioning
confidence: 99%
“…2017; Lim et al. 2018), but there are few studies regarding the effects of EH alone, and the associated underlying mechanisms.…”
Section: Introductionmentioning
confidence: 99%
“…), Lycium barbarum polysaccharide, Jatrorrhizine hydrochloride, oxyresveratrol, and alisol A isolated from Rhizoma alismatis (Oriental Waterplantain Tuber.) attenuated liver steatosis in HFD-fed animals via regulating lipogenic genes, predominantly relating with downregulation of SREBP-1c expression via AMPK activation Li W. et al, 2014;Lee Y. H. et al, 2016;Yang et al, 2016;Lee et al, 2018;Lim et al, 2018;Ho et al, 2019). Gangjihwan, a polyherbal composition of Ephedra intermedia Schrenk & C.A.Mey., Lithospermum erythrorhizon Siebold & Zucc., and Rheum palmatum L., showed anti-obesity and antinonalcoholic steatohepatosis effects in HFD-fed mice.…”
Section: Reducing Hepatic De Novo Lipogenesismentioning
confidence: 99%
“…GGEx18 was prepared from food-grade aqueous extracts of the three herbs: Laminaria japonica, Ephedra sinica, and Rheum palmatum (Hwalim, Busan, Korea). The composition of GGEx18 was described previously (Lim et al, 2018 Briefly, three dried herbs with their contents weighted were boiled together in distilled water for 22 h at 95℃. The aqueous extracts were then filtered and freeze-dried under vacuum for the production of GGEx18.…”
Section: Preparation Of Ggex18mentioning
confidence: 99%
“…Our previous study showed that GGEx18 was more effective than individual herbs with respect to antiobesity effects (Yoon et al, 2010). We recently reported that GGEx18 inhibited obesity, hepatic steatosis, and hepatic fibroinflammation in high-fat diet (HFD)-fed obese mice (Lim et al, 2018). Accordingly, we hypothesized that pancreatic fibroinflammation may be effectively regulated by GGEx18.…”
Section: Introductionmentioning
confidence: 99%