The Polymorphism in Acetaldehyde Dehydrogenase 2 Gene, Causing a Substitution of Glu &gt; Lys504, Is Not Associated with Coronary Atherosclerosis Severity in Han Chinese

Xu, Feng; Chen, Yu Guo; Geng, Yong; He, Zhao; Jiang, Chun Xiao; Sun, Yi; Li, Rui Jian; Sagar, M. Bidya; Xue, Li; Zhang, Yun

doi:10.1620/tjem.213.215

Cited by 20 publications

(27 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have confirmed that the severity of carotid atherosclerosis is positively correlated with CAD. Therefore, this study suggested that the ALDH2 *504Lys allele may be a protective factor for coronary atherosclerosis, which is contrary to clinical studies performed in China, Japan, and South Korea (Hashimoto et al 2002;Takagi et al 2002;Jo et al 2007;Xu et al 2007a).…”

Section: Aldh2 Polymorphism and Cadcontrasting

confidence: 89%

“…This enzyme has an important functional mononucleotide polymorphism rs671 (Glu504Lys polymorphism), which exists primarily in East Asians, with an incidence rate as high as 30-50% (approximately 6% of the world's population) (Li et al 2006;Li et al 2009). Initial studies only focused on the relationship between this polymorphism and alcohol-related diseases, such as hepatitis and digestive system tumors, but in recent years, an increasing number of studies have suggested an important association between ALDH2 Glu504Lys polymorphism and CAD (Takagi et al 2002;Jo et al 2007;Xu et al 2007aXu et al , b, 2011Guo et al 2010). In 2012, a genome-wide association (GWA) study further confirmed that the ALDH2 Glu504Lys polymorphism is associated with the susceptibility to CAD (Takeuchi et al 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Glu504Lys Polymorphism of Aldehyde Dehydrogenase 2 Contributes to Development of Coronary Artery Disease

Sun

Shang

et al. 2014

Tohoku J. Exp. Med.

Self Cite

View full text Add to dashboard Cite

Coronary artery disease (CAD) is a leading cause of death, and its genetic mechanism has been always a major research concern. Recently, increasing evidence has indicated that the aldehyde dehydrogenase 2 (ALDH2) polymorphism, known as Glu504Lys (rs671), may contribute to CAD development. ALDH2 has been well known as a key enzyme in alcohol metabolism, and subjects with *504Lys allele exist in 30-50% of the East Asian population (6% of the world's population). However, recent studies have indicated that the *504Lys allele of the ALDH2 gene may be associated with the pathogenesis of CAD in a given number of Chinese, Japanese, and Korean people. This discovery has been further confirmed by a genome-wide association study in 2012 that identified the link of ALDH2 Glu504Lys polymorphism to CAD susceptibility. ALDH2 may therefore serve as an important target for CAD intervention. Several studies have suggested that ALDH2 polymorphism plays an important role in the progress of CAD through multiple mechanisms, including the regulation of alcohol consumption, inflammation, endothelial progenitor cells, oxidative stress, asymmetric dimethylarginine, endothelial nitric oxide synthase, and other CAD-promoting factors. Furthermore, the ALDH2 Glu504Lys polymorphism has been shown to be associated with certain traditional cardiovascular risk factors, such as dyslipidemia, hypertension, and diabetes mellitus or hyperglycemia. In this review, we update the current research on the association of the Glu504Lys polymorphism with the susceptibility to CAD. We also highlight and discuss the underlying mechanisms, by which the ALDH2 Glu504Lys polymorphism may be targeted for the prevention and treatment of CAD.

show abstract

Section: Aldh2 Polymorphism and Cadcontrasting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

The Glu504Lys Polymorphism of Aldehyde Dehydrogenase 2 Contributes to Development of Coronary Artery Disease

Sun

Shang

et al. 2014

Tohoku J. Exp. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…32,33 Recent studies, including a pilot study of ours, suggested that this polymorphism was also associated with CAD. [26][27][28] In this study, we further investigated the association of the ALDH2 gene SNP with the coexistence of T2DM in CAD patients, and their relevance to alcohol consumption. To our knowledge, this is the first study in a Chinese population.…”

Section: Discussionmentioning

confidence: 99%

“…26 In brief, DNA was extracted from 200 ml of venous blood and extended using PCR. PCR products were purified and directly sequenced by an affiliated company of Invitrogen at Shanghai, China.…”

Section: Aldh2 Genotype Detectionmentioning

confidence: 99%

“…Previous studies have suggested that ALDH2 polymorphisms could be associated with increased risk of higher fasting plasma glucose (FPG), higher glycated hemoglobin A1c (HbA1c) or CAD; [25][26][27][28][29] however, the direct evidence of this polymorphism in relation to T2DM in CAD patients is still absent. Given the fact that genetically determined disease susceptibility is frequently population specific, in this study, we investigated whether the ALDH2 gene SNP is related to T2DM in CAD patients among Han Chinese.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients

Chen

et al. 2009

Hypertens Res

Self Cite

View full text Add to dashboard Cite

The prevalence of type II diabetes mellitus (T2DM) in coronary artery disease (CAD) patients has been steadily increasing, especially in East Asian countries. Although many studies have suggested that certain genetic variants may predispose to the development of T2DM, very few studies investigated the genetic link with T2DM in CAD patients of East Asia. In this study, we investigated the relationship between Glu504Lys polymorphism in the acetaldehyde dehydrogenase 2 (ALDH2) gene, a key enzyme of alcohol metabolism, and the risk of having T2DM in Chinese Han CAD patients. We enrolled 542 CAD patients (180 women and 362 men) and 309 CADÀ/DMÀ subjects (152 women and 157 men). T2DM was confirmed in 47.4% of CAD patients. Logistic and linear regression analyses showed that ALDH2 mutant genotypes (*1/*2 and *2/*2) were an independent risk factor for both T2DM in female CAD patients, even after controlling for alcohol consumption (OR¼1.95, P¼0.043), and fasting plasma glucose (FPG) in CADÀ/DMÀ women (P¼0.015), whereas the association with FPG disappeared after controlling for high-sensitivity C-reactive protein, a classic inflammatory biomarker. However, there was no relationship between the ALDH2 genetic polymorphism and T2DM or FPG in men. These findings suggest that the ALDH2 polymorphism is associated with an increased risk of T2DM in female CAD patients, and this association could be causal on the basis of the association between the polymorphism and FPG, which is partly explained by an increased inflammatory status. These findings will benefit the screening and treatment of a high-risk population in East Asians.

show abstract

Targeting ALDH2 in Atherosclerosis: Molecular Mechanisms and Therapeutic Opportunities

Cao

2019

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

The Polymorphism in Acetaldehyde Dehydrogenase 2 Gene, Causing a Substitution of Glu > Lys504, Is Not Associated with Coronary Atherosclerosis Severity in Han Chinese

Cited by 20 publications

References 14 publications

The Glu504Lys Polymorphism of Aldehyde Dehydrogenase 2 Contributes to Development of Coronary Artery Disease

The Glu504Lys Polymorphism of Aldehyde Dehydrogenase 2 Contributes to Development of Coronary Artery Disease

ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients

Targeting ALDH2 in Atherosclerosis: Molecular Mechanisms and Therapeutic Opportunities

Contact Info

Product

Resources

About