The polymorphism rs2268574 in Glucokinase gene is associated with gestational Diabetes mellitus

Frigeri, Henrique Ravanhol; Martins, Laysa Toschi; Auwerter, Nathalia Cavalheiro; Santos-Weiss, Izabella Castilhos Ribeiro dos; Pedrosa, Fábio O.; Souza, Emanuel Maltempi de; Rego, Fabiane Gomes de Moraes

doi:10.1016/j.clinbiochem.2014.01.024

Cited by 9 publications

(4 citation statements)

References 5 publications

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“… 20 – 22 This variant was not present in the controls in our study, but found in one of the females with GDM. One of the polymorphisms (c.676+38 T>C) observed in our population subset has been previously reported by Frigeri et al 17 to be associated with GDM, in Euro-Brazilian population. In contrast, we observed a higher frequency of this polymorphism in the subjects taken as controls as compared with the subjects with GDM.…”

Section: Discussionsupporting

confidence: 82%

GCK Gene Screening and Association of GCK Variants With Gestational Diabetes in North Indian Population

Siddiqui

Waghdhare

Gopi

et al. 2018

Clin Med Insights Endocrinol Diabetes

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Background:GCK gene variants have been reported to be associated with gestational diabetes mellitus (GDM) in the Caucasian population. There are no reports exploring this association in the Indian population.Methods:This cross-sectional study included subjects from Max Super Speciality Hospital, New Delhi, India, over a span of 6 months. Females diagnosed with GDM as per the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria were enrolled. Direct gene sequencing was performed to screen all 10 exons and promoter region of GCK gene.Results:Out of the total 1000 females screened, 154 subjects had any degree of hyperglycemia. GCK gene screening was done and we observed 11 variants in 80.4% (41/51) of the GDM subset and 89.6% (43/48) of the controls. Allele frequencies of observed variants were not different between the control subjects (12.5%) and those diagnosed with GDM (8.4%).Conclusion:To the best of our knowledge, this is the first report from north India exploring association of GCK variants with GDM and we do not observe any association of GCK variants with GDM in our study population.CTRI Registration No: CTRI/2017/07/008964

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Section: Discussionsupporting

confidence: 82%

GCK Gene Screening and Association of GCK Variants With Gestational Diabetes in North Indian Population

Siddiqui

Waghdhare

Gopi

et al. 2018

Clin Med Insights Endocrinol Diabetes

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“…Genetic studies of GDM in Latin American women have yielded varied findings. In Brazilian women, GDM has been associated with the glucokinase gene ( 278 ), the MTNR1B gene polymorphism rs10830963 ( 279 ), LGALSI polymorphism ( 280 ) and IRS-1 ( 281 ). In Mexican women, GDM has been associated with polymorphisms of the HNF4A gene ( 282 ), the TNF-α gene promoter ( 283 ), the MTNR1B gene ( 284 ), the CENTD2 gene ( 284 ), the KCNQ1 haplotype ( 284 ), and the TCF7L2 gene ( 284 , 285 ).…”

Section: Etiology Of Type 2 Dm In Hispanics/latinosmentioning

confidence: 99%

From Sea to Shining Sea and the Great Plains to Patagonia: A Review on Current Knowledge of Diabetes Mellitus in Hispanics/Latinos in the US and Latin America

et al. 2017

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The past two decades have witnessed many advances in the prevention, treatment, and control of diabetes mellitus (DM) and its complications. Increased screening has led to a greater recognition of type 2 diabetes mellitus (type 2 DM) and prediabetes; however, Hispanics/Latinos, the largest minority group in the US, have not fully benefited from these advances. The Hispanic/Latino population is highly diverse in ancestries, birth places, cultures, languages, and socioeconomic backgrounds, and it populates most of the Western Hemisphere. In the US, the prevalence of DM varies among Hispanic/Latino heritage groups, being higher among Mexicans, Puerto Ricans, and Dominicans, and lower among South Americans. The risk and prevalence of diabetes among Hispanics/Latinos are significantly higher than in non-Hispanic Whites, and nearly 40% of Hispanics/Latinos with diabetes have not been formally diagnosed. Despite these striking facts, the representation of Hispanics/Latinos in pharmacological and non-pharmacological clinical trials has been suboptimal, while the prevalence of diabetes in these populations continues to rise. This review will focus on the epidemiology, etiology and prevention of type 2 DM in populations of Latin American origin. We will set the stage by defining the terms Hispanic, Latino, and Latin American, explaining the challenges identifying Hispanics/Latinos in the scientific literature and databases, describing the epidemiology of diabetes—including type 2 DM and gestational diabetes mellitus (GDM)—and cardiovascular risk factors in Hispanics/Latinos in the US and Latin America, and discussing trends, and commonalities and differences across studies and populations, including methodology to ascertain diabetes. We will discuss studies on mechanisms of disease, and research on prevention of type 2 DM in Hispanics/Latinos, including women with GDM, youth and adults; and finalize with a discussion on lessons learned and opportunities to enhance research, and, consequently, clinical care oriented toward preventing type 2 DM in Hispanics/Latinos in the US and Latin America.

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“…Babies born from mothers with GDM are prone to suffer from macrosomia, congenital deformities, hypoglycemia, respiratory distress syndrome and neonatal trauma [8]. Since 2010, the International Association of diabetes and pregnancy study group has divided gestational diabetes into two categories: overt diabetes mellitus (ODM) and gestational diabetes mellitus (GDM) [9]. ODM is defined as blood glucose ≥ 7.0 mmol/L or HbA1C ≥ 6.5% during the first prenatal examination.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on Clinical Characteristics and Outcomes of Overt Diabetes Mellitus and Gestational Diabetes Mellitus in Late Pregnancy

Wang¹,

Wu²

2020

OJOG

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Background: With the rising prevalence in recent years, gestational diabetes mellitus has become one of the leading causes of maternal and child mortality and morbidity worldwide and has raised health concern. It is seriously detrimental to both the women and fetuses. However, there are limited evidences of two types of gestational diabetes mellitus on clinical characteristics and outcomes. Therefore, this study was aimed to explore the clinical characteristics and outcomes of patients with overt diabetes mellitus (ODM) and gestational diabetes mellitus (GDM) at the late pregnancy. Methods: From January 2015 to August 2016, totally 63 gestational diabetes mellitus from the Department of Clinical Nutrition in Beijing Anzhen Hospital were enrolled in the study. Patients were classified into two groups. 31 patients with gestational overt diabetes mellitus were grouped into ODM group and 32 patients with gestational diabetes mellitus were grouped into GDM group. Clinical characteristics and outcomes were compared between ODM and GDM. We collected records of the age, gestational week, family history, past history, pregnancy complications, insulin use, blood pressure, clinical nutrition indexes, blood pressure. Glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), total protein (TP), albumin (ALB), prealbumin (PALB), hemoglobin (HGB), urea nitrogen (BUN), serum creatinine (CREA), and dynamic blood glucose monitoring were measured. And we recorded the changes of blood glucose and the test data. We statistically analyzed the data of two groups. Results: In the ODM group, HbA1c, FBG, average blood glucose, two-hour postprandial blood glucose (2hPBG) after breakfast, 2hPBG after dinner, the number of hyperglycemic events and high blood glucose time ratio are significantly higher than those of GDM and two groups compared with statistical significance (P < 0.05). The number of patients treated with insulin (10/31) in ODM is significantly more than that in GDM (1/32) (P < 0.05). 45% (14/31

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The polymorphism rs2268574 in Glucokinase gene is associated with gestational Diabetes mellitus

Cited by 9 publications

References 5 publications

GCK Gene Screening and Association of GCK Variants With Gestational Diabetes in North Indian Population

GCK Gene Screening and Association of GCK Variants With Gestational Diabetes in North Indian Population

From Sea to Shining Sea and the Great Plains to Patagonia: A Review on Current Knowledge of Diabetes Mellitus in Hispanics/Latinos in the US and Latin America

Comparative Study on Clinical Characteristics and Outcomes of Overt Diabetes Mellitus and Gestational Diabetes Mellitus in Late Pregnancy

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