The polysaccharide extracts from the fungi <i>Coprinus comatus</i> and <i>Coprinellus truncorum</i> do exhibit AChE inhibitory activity

Pejin, Boris; Tešanović, Kristina; Jakovljević, Dragica; Kaišarević, Sonja; Šibul, Filip; Rašeta, Milena; Karaman, Maja

doi:10.1080/14786419.2017.1405417

Cited by 48 publications

(19 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the literature, there is only one study about AChE inhibitory activity of the mushroom polysaccharide extracts. Pejin et al () screened AChE inhibitory activity of the polysaccharide extracts of Coprinellus truncorum and Coprinus comatus mushrooms and IC 50 values of both extracts were found as 0.61 ± 0.03 and 0.62 ± 0.07 mg/ml, respectively. This is the first study about anticholinesterase inhibitory activity of FF, FT, GAD, GAP, GL, PH, PO, and PP polysaccharides.…”

Section: Resultsmentioning

confidence: 99%

Structural characterization and determination of biological activities for different polysaccharides extracted from tree mushroom species

et al. 2019

View full text Add to dashboard Cite

Chemical composition and structural characterization of polysaccharides of Fomes fomentarius (FF), Fuscoporia torulosa, Ganoderma adspersum, Ganoderma applanatum (GAP), Ganoderma lucidum, Phellinus igniarius, Pleurotus ostreatus (PO), and Porodaedalea pini (PP) tree mushrooms with antioxidant and anticholinesterase activities were determined in this research. Total carbohydrate contents of the polysaccharides were ranged between 65.06 ± 6.76 and 88.27 ± 5.15 µg/mg and total protein contents were ranged between 3.18 ± 0.72 and 6.56 ± 1.25 µg/mg. Galactose, glucose, and mannose were identified as major monosaccharides in all polysaccharides using gas chromatography‐mass spectrometry. FT‐IR analysis showed the characteristic peaks of the polysaccharides and high performance liquid chromatography‐diode array detection was used to determine the molecular weight of the polysaccharides. In β‐carotene–linoleic acid assay FF (IC50: 2.55 ± 0.40 µg/ml) displayed the highest antioxidant activity, whereas GAP indicated the highest antioxidant activity in cupric reducing antioxidant capacity (A0.50:59.90 ± 0.53 μg/ml), ABTS•+ (IC50: 16.62 ± 0.31 μg/ml), and DPPH• (IC50: 45.58 ± 0.21 μg/ml) assays. In cholinesterase inhibitory activity test, PO (56.31±0.0.74%) showed significant inhibitory activity against butyrylcholinesterase enzyme. Practical applications Polysaccharides from mushrooms are the major class of bioactive compounds with various biological activities. Several studies were performed on the biological activity of the polysaccharide extracts from different mushrooms. However, to our knowledge, this is the first report on the chemical composition, structural characterization, antioxidant, and anticholinesterase activities of extracted polysaccharides from studied mushrooms in detail. This investigation shows that polysaccharide extracts obtained from tree mushrooms show a significant bioactivity and these polysaccharides might be used as bioactive natural sources in the pharmaceutical, food, and cosmetic industries.

show abstract

Section: Resultsmentioning

confidence: 99%

Structural characterization and determination of biological activities for different polysaccharides extracted from tree mushroom species

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The extract from CC had AChE inhibitory potential and reached IC 50 value of 0.62 mg/mL. The results of the study emphasize the possibility of using CC extracts in the palliative therapy of Alzheimer's disease (Pejin et al, 2019).…”

Section: Acetylcholinesterase Inhibitory Propertymentioning

confidence: 71%

The two faces of Coprinus comatus—Functional properties and potential hazards

Nowakowski

Naliwajko

Markiewicz‐Żukowska

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

Mushrooms have been used for centuries not only as food but also in traditional medicine as a source of components with pro-health activity. One of them is Coprinus comatus (O.F.Müll.) Pers. also called shaggy mane, chicken drumstick mushroom, or lawyer's wig. In Asian countries, C. comatus (CC) is approved as edible mushroom and often cultivated for consumption, whereas in many other countries, although it is widespread, it is unrecognized and not used. In this review, for the first time, we discussed about the composition related to functional properties as well as the potential risks associated with consumption of CC by reviewing scientific literature. The information has been collected in order to get to know this species thoroughly. Various studies show many of the physiological activities, such as antioxidant, anticancer, antiandrogenic, hepatoprotective, acetylcholinesterase inhibitory, antiinflammatory, antidiabetic, antiobesity, antibacterial, antifungal, antinematode, and antiviral. Besides positive physiological properties, CC has also negative features, for example, skin reactions in patients with dermatitis and atopic predisposition, risk of confusion with poisonous mushrooms, quick autolysis after collection, and contamination of toxic elements.

show abstract

“…Jamur ini belum dimanfaatkan oleh masyarakat adat Penembahen. Beberapa jenis dari genus Coprinus dilaporkan dapat dikonsumsi seperti C. comatus, C. sterquilinus, dan C. truncorum yang berpotensi sebagai bahan pangan, antibakteri, dan inhibitor acetylcholinesterase (Yaseen et al, 2016;Pejin et al, 2019;Emsen & Guven, 2020;Evita et al, 2020). Jamur berikutnya dari suku Lyophyllaceae adalah Termitomyces sp.…”

Section: Pembahasanunclassified

Deskripsi dan Potensi Cendawan Makro Asal Hutan Adat Penembahen, Desa Juhar, Kabupaten Tanah Karo, Sumatera Utara

Sibero

Putra

Murwani

2021

JMI

View full text Add to dashboard Cite

Jamur merupakan salah satu penyusun ekosistem hutan yang memiliki peran penting sebagai dekomposer. Namun kajian mengenai keragaman organisme ini di Indonesia masih sangat rendah, khususnya pada hutan adat. Penelitian ini dilakukan dengan tujuan untuk mendata, mendeskripsikan serta mengetahui potensi pemanfaatan jamur yang ditemukan di hutan adat Penembahen yang terdapat di Desa Juhar, Kabupaten Karo, Sumatra Utara. Identifikasi jamur dilakukan dengan mengamati karakteristik makroskopisnya. Penelitian ini berhasil mendeskripsikan 12 jenis jamur, 11 di antaranya termasuk filum Basidiomycota dan satu jenis termasuk filum Ascomycota. Kajian ini merupakan laporan pertama mengenai keberadaan jamur di lokasi penelitian.

show abstract

The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity

Cited by 48 publications

References 16 publications

Structural characterization and determination of biological activities for different polysaccharides extracted from tree mushroom species

Structural characterization and determination of biological activities for different polysaccharides extracted from tree mushroom species

The two faces of Coprinus comatus—Functional properties and potential hazards

Deskripsi dan Potensi Cendawan Makro Asal Hutan Adat Penembahen, Desa Juhar, Kabupaten Tanah Karo, Sumatera Utara

Contact Info

Product

Resources

About