The position of transferred air bubbles after embryo transfer is related to pregnancy rate

Can the Movement of the Air Bubbles After Embryo Transfer Predict the Success of IVF Treatment?

“…Furthermore, in our previous study, we also demonstrated that clinical PRs appeared higher in cases with air bubbles closer to the fundus, and a distance of <10 mm from the fundal endometrial surface seems likely to be the optimal position of the air bubbles for successful ET. A prospective data-analysis of 367 US-guided ETs found the highest PRs in fundal transfers [12]. A retrospective cohort study designed by Friedman et al included 315 non-donor blastocyst (BT) transfers and suggested that BT closer to the fundus is associated with a higher PR [10].…”

Increasing Pregnancy by Improving Embryo Transfer Techniques

“…The presence of two air bubbles on both sides of the medium that contains the embryo prevents the transfer of the embryo within the catheter (Eytan et al, 2004) and beside, in the transfer under ultrasonographic guidance, the air bubbles are often considered a marker for the embryo's position in the uterus (Lambers et al, 2007). Finally by loading 1 µl of medium on the catheter tip, the probability of embryo expulsion will be stopped.…”

“…The transferred air bubbles are often considered a marker for the embryo's position in the uterus. By performing the transfer under ultrasonographic guidance, the catheter and air bubble can be precisely located (Lambers et al, 2007). Based on some studies, catheter insertion at 1.5 or 2 cm from the fundus is better than insertion at 1 cm from the fundus (Coroleu et al, 2002).…”

“…Based on some studies, catheter insertion at 1.5 or 2 cm from the fundus is better than insertion at 1 cm from the fundus (Coroleu et al, 2002). The air bubble position at embryo transfer is relevant to the pregnancy rate (Lambers et al, 2007).…”

Embryo Transfer with Controlled Injection Speed to Increase Pregnancy Rates: A Randomized Controlled Trial

“…Several studies [13,17,18,19,20,21,22,23] have demonstrated that the depth of the embryo placement into the uterine cavity, as a result of the embryo transfer technique, should be considered an important factor concerning pregnancy rates. Our research group pointed out that despite standardization of the transfer by protocol, the final position of the transferred air bubbles including the embryo(s) was not accurately predictable because of dependency of the injection speed which depends on the force used to press the plunger, the resistance of the plunger and a possible uterine resistance during transfer [24]. …”