The possibility of using neuron-specific enolase as a biomarker in the acute period of stroke

Топузова, М. П.; Алексеева, Т. М.; Panina, E. B.; Вавилова, Т. В.; Kovzelev, Pavel D.; Portik, O. A.; Skoromets, A. A.

doi:10.17116/jnevro201911908253

Cited by 8 publications

(5 citation statements)

References 56 publications

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“…NSE and S100β levels can reflect the degree of brain tissue damage. [ 40 , 41 ] The results of the meta-analysis showed that acupuncture significantly improved the related indicators of SAs and was superior to the control in reducing the S100β level. ( P < .05) Nevertheless, the effect of lowering the NSE level was comparable to that of the control ( P > .05), indicating that acupuncture has an excellent therapeutic effect on SAs.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of acupuncture in the treatment of stroke complicated with sleep apnea syndrome: A systematic review and meta-analysis of randomized controlled trials

et al. 2023

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Background: stroke patients often have a combination of sleep apnea syndrome, which is an important and modifiable risk factor for stroke prognosis. Acupuncture is one of the measures for sleep apnea syndrome, and it is also widely used in stroke. However, we are concerned that its efficacy and safety in the treatment of stroke with sleep apnea syndrome are not yet clear. Methods: This systematic review and meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses schema and was registered with INPLASY (registration number: INPLASY202250113). The following 8 databases were searched: PubMed, Cochrane Library (CENTRAL), Embase, Web of Science, China National Knowledge Infrastructure, Chongqing VIP Information, WanFang Data, and China Biomedical Literature Database limited from the establishment of each database to May 4, 2022. Subject headings, free words, and keywords were used for retrieval. Relevant literature was supplemented by consulting other resources. We assessed the risk of bias in the included studies using the Cochrane risk of bias tool. RevMan 5.4 software (The Cochrane Collaboration, 2020) was used to perform the meta-analysis. Results: Six records were included, including a total of 513 participants: 256 in the experimental group and 257 in the control group. The results showed that the total effective rate (relative risk = 1.23, 95% confidence interval (CI): 1.13, 1.34, P < .00001), apnea-hypopnea index (mean difference (MD) = −8.39, 95% CI: −9.19, −7.59, P < .00001), Epworth Sleepiness Scale score (MD = −1.59, 95% CI: −2.66, −0.52, P = .004), minimal oxygen saturation (MD = 4.99, 95% CI: 3.5, 6.47, P < .00001), longest duration of apnea (MD = −7.47, 95% CI: −8.97, −5.97, P < .00001), longest duration of apnea (MD = −6.48, 95% CI: −8.60, −4.35, P < .00001), and S100β levels (standard mean difference = −1.52, 95% CI: −1.87, −1.18, P < .00001) were better in the experimental group than in the control group. Simultaneously, the effect of reducing the neuron-specific enolase level in the experimental group was comparable to that in the control group (MD = -3.40, 95% CI: −9.08, 2.29, P = .24). Conclusions: Acupuncture can improve the clinical symptoms and related laboratory indicators for sleep apnea syndrome in patients with stroke. More high-quality trials remain urgently needed.

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Section: Resultsmentioning

confidence: 99%

Efficacy and safety of acupuncture in the treatment of stroke complicated with sleep apnea syndrome: A systematic review and meta-analysis of randomized controlled trials

et al. 2023

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“…A number of previous studies examined the role of NSE in glycolysis in neural and neuroendocrine tissues. The ability of serum NSE levels to predict functional neurological outcomes in stroke patients is a matter of recent interest, with some studies suggesting that NSE is useful in predicting functional outcomes [30][31][32][33]. Zaheer et al studied 75 patients who suffered from acute ischemic stroke to estimate the relationship between levels of NSE at admission and infarct volume, the severity of the stroke, and early functional neurological outcome.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Postoperative Serum Neuro-Specific Enolase Levels with Postoperative Delirium Occurring after Microvascular Depression Surgery in Older Patients

Guo

Liu

et al. 2022

JVD

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There is a high incidence of postoperative delirium (POD) following microvascular decompression (MVD) surgery. Neuronal survival, differentiation, and neurite regeneration are regulated by neuro-specific enolase (NSE). Therefore, we investigated and assessed whether circulating NSE levels are related to POD after MVD surgery. We recruited a total of 209 patients and 209 age- and gender-matched healthy controls. A retrospective review of electronic medical records was conducted, and serum NSE levels were measured in the serum of patients before and after surgery, as well as the serum of controls. Patients were categorized according to the presence of POD. Postoperative patient serum levels of NSE were significantly higher compared to preoperative levels. Additionally, postoperative serum NSE levels were remarkably higher in POD patients than non-POD patients. In addition, there was no significant correlation between NSE levels and the type and severity of postoperative delirium. Age (OR = 1.153, 95% CI = 1.040–1.277, p = 0.006), the levels of serum NSE (OR = 1.326, 95% CI = 1.177–1.494, p < 0.001), and the levels of serum S100β (OR = 1.006, 95% CI = 1.000–1.012, p = 0.048) were the three independent variables for predicting POD. A significant correlation existed between serum S100β levels and serum NSE levels (t = 2.690, p = 0.008). In terms of area under the precision–recall curve, the discriminatory ability of serum NSE levels (AUC = 0.876, 95% CI = 0.829–0.924, p < 0.0001) was close to that of the serum S100β level (AUC = 0.879, 95% CI = 0.825–0.933, p < 0.0001) and significantly higher than that of age (AUC = 0.813, 95% CI = 0.755–0.871, p < 0.0001). Combining all three features produced a dramatic improvement over individual effects. The NSE level in serum was a stronger indicator of the likelihood of POD after MVD surgery in the older population. The clinical determination of this factor might be useful for distinguishing older patients at risk of POD after MVD surgery on the basis of their clinical findings.

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“…The term "neuron-specific enolase" is misleading because γγ enolase and the hybrid molecular form of γα enolase have different structures, are produced by different cells, and may have different functions [53,59]. Many studies of neuron-specific enolase in ischemic and hemorrhagic stroke have relied on immunoenzymatic assays that detect both the γγ enolase isoenzyme and the hybrid form of γα enolase [39][40][41][42][43][44][45]. In this regard, the results of several studies on NSE in acute cerebrovascular accidents have been inconsistent.…”

Section: Methodology Of the Enolase Study: What Are We Measuring?mentioning

confidence: 99%

“…Another group of studies found no clinical significance in measuring NSE [39][40][41][42][43][44][45]. Huţanu et al found no significant differences in serum NSE concentrations between patients with ischemic stroke and controls, and high NSE levels were associated with a better outcome.…”

Section: Introductionmentioning

confidence: 99%

“…A systematic review by Anand et al [40] found no link between NSE levels and functional outcomes or stroke severity. NSE has not been shown to help distinguish between ischemic and hemorrhagic stroke [41]. Conflicting results have been obtained regarding the validity of NSE concentrations in the late phase of ischemic stroke after endovascular treatment [42].…”

Section: Introductionmentioning

confidence: 99%

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Neuron-Specific Enolase—What Are We Measuring?

Babkina,

Lyubomudrov,

Golubev

et al. 2024

IJMS

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Since the discovery of the neuron-specific protein by Moore and McGregor in 1965, tens of thousands of studies have investigated the basic and applied significance of neuron-specific enolase (NSE). This promising biomarker, according to many researchers, has not found widespread use in clinical practice, particularly in acute cerebrovascular accidents. Moreover, the several studies refuting the usefulness of serum NSE measurement in critically ill patients leads us to consider the reasons for such contradictory conclusions. In this article, we have analyzed the main directions in the study of NSE and expressed our perspective on the reasons for the contradictory results and the difficulties in implementing the results of these studies in clinical practice. In our opinion, the method of the enzyme-linked immunosorbent assay (ELISA) used in the majority of the studies is inappropriate for the evaluation of NSE as a marker of central nervous system damage, because it does not allow for the differentiation of heterodimers of enolases and the assessment of the enzymatic activity of this group of enzymatic proteins. Therefore, the methodological approach for the evaluation of NSE (γγ-enolase) as a biomarker needs to be elaborated and improved. Furthermore, the specificity of the applied research methods and the appropriateness of the continued use of the term “neuron-specific enolase” must be addressed.

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The possibility of using neuron-specific enolase as a biomarker in the acute period of stroke

Cited by 8 publications

References 56 publications

Efficacy and safety of acupuncture in the treatment of stroke complicated with sleep apnea syndrome: A systematic review and meta-analysis of randomized controlled trials

Efficacy and safety of acupuncture in the treatment of stroke complicated with sleep apnea syndrome: A systematic review and meta-analysis of randomized controlled trials

Relationship of Postoperative Serum Neuro-Specific Enolase Levels with Postoperative Delirium Occurring after Microvascular Depression Surgery in Older Patients

Neuron-Specific Enolase—What Are We Measuring?

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