The possible options for the prevention of preeclampsia

Fodor, A.; Győrffy, András; Váradi, M.; Fülesdi, Béla; Major, Tamás

doi:10.1556/oh.2012.29267

Cited by 3 publications

(2 citation statements)

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“…High-risk cases and low-risk cases were divided using Coopland risk factor scoring. Anemia in pregnancy affects not only the health of the mother but also the outcome of the pregnancy and the health of the baby, resulting in an intergenerational cycle of anemia, malnutrition, etc., known public health issues that are more prevalent in developing countries than in developed ones and any other health problems 4,[16][17] .…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes of Women in Two Health Institutes; A Cross-Sectional Study in Pakistan

Munawar¹,

Mustafa²,

Arif³

et al. 2022

PJMHS

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Background: Complications that could be fatal can affect nearly 15% of pregnant women. As a result, it will be helpful to direct the appropriate intervention if a high-risk pregnancy is identified early on. Objectives: This study was aimed to ascertain the outcomes of pregnancies among pregnant women. Methods: In this study, age groups of 20-40 years of women were involved, among them, 60 women from each hospital participated. The majority of women were from rural areas. The occupation of majority of women husband in DHQ was farming (33.33%), followed by laborer (40%), teaching (16.65%) and trading (10%), while majority of husbands of patients in KTMC were laborer (38.33%) followed by farming (36.66%), teaching (13.33%) and trading (11.66%). Results: The normal weight of children in DHQ and KTMC was recorded 75 and 68.33%, respectively. In DHQ and KTMC, 50 and 38.33% children born alive, respectively while 26.66 and 35% abortions occurred, respectively. Neonatal outcome was linked to pregnancy complications and perinatal morbidity. Practical implications: This study focused on the neonatal health and the pregnancy outcome of the pregnant women. Improvement in vaginal birth, improvement of neonatal birth weight but caesarean section in high-risk mothers was analyzed in this study. Conclusion: The majority of maternal morbidities could be avoided if the mother had access to timely and appropriate healthcare during her pregnancy. As a result, proper care and prompt referral can help reduce perinatal mortality and morbidity and possibly improve maternal outcomes. Keywords: Pregnancy; Outcomes; Complications; Low birth weight; prenatal care

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Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes of Women in Two Health Institutes; A Cross-Sectional Study in Pakistan

Munawar¹,

Mustafa²,

Arif³

et al. 2022

PJMHS

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“…A praeeclampsia megelőzésében hatékony lehet a kis molekulatömegű heparinnal és kis dózisú aszpirinnel (LMWH+LDA) végzett kettős thrombosisgátló kezelés [51]. A nagy kockázatú csoportba tartozó nők körében (megelőző súlyos, korai praeeclampsia, kis születési súlyú újszü-lött) kutatást végeztek, és az említett kettős kezelésben részesülők csoportjában az ismétlődő praeeclampsia kialakulása 3% volt, szemben a kizárólag kis dózisú aszpirinnel kezelt csoporttal, ahol 30%-os ismétlődési gyakoriságot tapasztaltak [52].…”

Section: A Haemostasis Változásaiunclassified

The pathophysiology of preeclampsia in view of the two-stage model

Alasztics

Kukor²,

Pánczél

et al. 2012

Orvosi Hetilap

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A praeeclampsia gyakori és súlyos terhességi kórkép, az anyai és magzati morbiditás és mortalitás egyik vezető oka. A betegség jellemzői a 20. gesztációs hét után kialakult hypertonia és proteinuria, gyakran oedema és több más szubjektív tünet kísérheti. A betegség kiváltó oka a placentában keresendő, a betegség következményei viszont több szervrendszert érintenek. A kétlépcsős modell szerint a placenta kritikus elváltozásai -az abnormális implantá-ció, csökkent lepényi perfúzió -következtében (első lépcső) a keringésbe olyan faktorok kerülnek, amelyek az anyai tünetek megjelenéséért (második lépcső) felelősek. A placenta kórélettanában jelentős szerepet játszik az oxidatív stressz, a nitrogén-monoxid-szintáz enzim csökkent működése, valamint számos sejtes és humorális immunológiai tényező. A manifeszt betegség tüneteinek közös nevezője az endotheldiszfunkció. Az elmélet a hypertonia, proteinuria és oedema triászát és egyéb tünetek eredetét is képes magyarázni. Orv. Hetil., 2012Hetil., , 153, 1167Hetil., -1176 Kulcsszavak: praeeclampsia, nitrogén-monoxid-szintáz, oxidatív stressz, endotheldiszfunkció The pathophysiology of preeclampsia in view of the two-stage modelPreeclampsia is a common and severe disease in pregnancy, a major cause of maternal and fetal morbidity and mortality. The main features of the disease are de novo hypertension after the 20th gestational week and proteinuria, and it is frequently accompanied by edema and other subjective symptoms. The origin of the disease is the placenta, but its sequelae affect multiple organ systems. According to the two-stage model of preeclampsia, the abnormal and hypoperfused placenta (stage 1) releases factors to the bloodstream, which are responsible for the maternal symptoms (stage 2). Oxidative stress, impaired function of nitric-oxide synthase, cellular and humoral immunological factors play an important role in the pathophysiology of the placenta. Endothelial dysfunction is the common denominator of the clinical symptoms. The theory explains the origins of hypertension, proteinuria, edema and other symptoms as well. Orv. Hetil., 2012, 153, 1167-1176 Keywords: preeclampsia, nitric-oxide synthase, oxidative stress, endothelic dysfunction (Beérkezett: 2012. május 16.; elfogadva: 2012. június 7.) Rövidítések ADMA = aszimmetrikus dimetil-arginin; Akt = Akt-kináz, más néven: proteinkináz B (PKB); ASK1 = apoptosis-regulating signal kinase 1; AT1-AA = angiotenzin II 1-es típusú receptorához kötődő agonista hatású antitestek; BH4 = tetrahidrobiopterin; COX = ciklooxigenáz; dNK = decidualis NK-sejt; eNOS = endothelialis nitrogén-monoxid-szintáz; FFA = (free fatty acid) szabad zsírsav; GOT = glutamát/oxálacetát transzamináz; GPT = glutamát/piruvát transzamináz; GTPCH = guanozin-trifoszfát ciklohidroláz; HELLP = haemolyticus anaemia, emelkedett májenzimek, thrombocytopenia; HLA = humán leukocyta-antigén; Hsp90 = hősokkprotein 90; IUGR = intrauterine growth restriction; MAHA = microangiopathiás haemolyticus anaemia; NF-κB = nukleáris faktor kappa-B; PAI = plazminogén...

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Egg consumption and growth in children: a meta-analysis of interventional trials

Larson,

Zhao,

Bader-Larsen

et al. 2024

Front. Nutr.

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IntroductionStunting and wasting are prevalent in low- and middle-income countries, putting children at risk for disease and disability. Eggs are a nutrient-rich food that can potentially facilitate growth.PurposeThe aim of this meta-analysis was to evaluate the potential beneficial effect of egg supplementation on growth in children.MethodsFollowing the PRISMA guidelines, PubMed and Healthline (Ovid) were systematically searched for interventional studies on egg supplementation for growth in children aged 6 months to 18 years, with no restrictions on date. Studies were evaluated for quality using Cochrane’s GRADE technique. Data were pooled and reported as means and 95% confidence intervals.ResultsSeven studies reporting on 9 unique interventions in 3,575 male and female participants were included in the meta-analysis. Participants in the intervention groups experienced significantly greater increases in height/length (by 0.47 [0.13, 0.80] cm, p < 0.01) and weight (by 0.07 [0.01, 0.13] kg, p = 0.03) when compared to those in the control groups.ConclusionEggs are an affordable, nutritious option for improving growth in children, though more studies with longer interventions are warranted.Systematic review registration: PROSPERO (CRD42021289609: https://www.crd.york.ac.uk/prospero/).

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The possible options for the prevention of preeclampsia

Cited by 3 publications

References 50 publications

Pregnancy Outcomes of Women in Two Health Institutes; A Cross-Sectional Study in Pakistan

Pregnancy Outcomes of Women in Two Health Institutes; A Cross-Sectional Study in Pakistan

The pathophysiology of preeclampsia in view of the two-stage model

Egg consumption and growth in children: a meta-analysis of interventional trials

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