The post-streptococcal diseases in the clinical practice

Av, Aksenova; Na, Shostak; Oa, Guseva

doi:10.17116/otorino201681239-43

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…Большинство исследований, проведенных до настоящего времени, доказывает важное значение внебольничной пневмонии, вызванной S. pneumoniae, в возникновении ССО у коморбидных пациентов [7,8]. Pseudomonas aeruginosa -один из самых распространенных возбудителей пневмонии и сепсиса в условиях стационара, уровень летальности которой достигает 30%.…”

Section: Discussionunclassified

Predictors of cardiovascular events in patients with heart failure and <i>Pseudomonas aeruginosa</i> pneumonia

Podzolkov,

Tarzimanova,

Ponomareva

et al. 2024

Russ J Cardiol

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Aim. To identify predictors of cardiovascular events (CVEs) in patients with heart failure (HF) and P. aeruginosa pneumonia.Material and methods. The study included 92 patients with HF with mildly reduced or reduced ejection fraction and nosocomial pneumonia. Based on sputum or bronchoalveolar lavage microbiological examination, patients were divided into 2 following groups: group I — 51 patients with HF and P. aeruginosa pneumonia, group II — 41 patients with HF and pneumonia caused by other pathogens (Staphylococcus aureus, Streptococcus pneumoniae). During the hospital stay, the following morbidities were assessed: cardiovascular death, acute coronary syndrome, non-fatal cerebrovascular accident, pulmonary embolism, lower extremity venous thrombosis.Results. CVEs were significantly more often observed in patients with HF and P. aeruginosa pneumonia — 30 (58,8%) than in patients with HF and pneumonia caused by S. aureus or S. pneumoniae — 5 (12,1%). Complete blood count in group I patients revealed a decrease in hemoglobin level to 114 [95; 133] g/l, when compared with patients in group II — 139 [118; 150] g/l (p<0,001) and an increase in white blood cell count (10,2×109/l and 6,96×109/l, respectively (p<0,001)). A biochemical blood test in group I patients revealed a significant increase in C-reactive protein (CRP) of 105 [60; 191] and 18 [14; 55,1] mg/l (p<0,001). Patients with P. aeruginosa pneumonia had more widespread lung involvement than patients with pneumonia of other etiologies.Conclusion. There are following most significant predictors of cardiovascular events in patients with HF and P. aeruginosa pneumonia: decreased LVEF <40% (relative risk (RR) 1,833; 95% confidence interval (CI) 1,188-3,400; p=0,005), white blood cell count >11×109/l (RR 2,412; 95% CI 1,399-4,158; p=0,048), CRP >133 mg/l (RR 3,115; 95% CI 1,611-6,025; p<0,001) and hypoproteinemia <57 g/l (RR 5,225; 95% CI 1,249-21,854; p=0,012).

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Section: Discussionunclassified

Predictors of cardiovascular events in patients with heart failure and <i>Pseudomonas aeruginosa</i> pneumonia

Podzolkov,

Tarzimanova,

Ponomareva

et al. 2024

Russ J Cardiol

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“…В ЛІКУВАННІ ХРОНІЧНИХ ЗАПАЛЬНИХ ЗАХВОРЮВАНЬ ПІДНЕБІННИХ МИГДАЛИКІВ 1 Безшапочний СБ, 2 Полянська ВП, 1 Зачепило СВ Матеріали та методи: В дослідженні брали участь 52 хворих на хронічний тонзиліт. Всіх обстежених було розподілено на 2 групи по 26 осіб в кожній.…”

Section: клінічна та мікробіологічна ефективність «біоплазміксу спрею...unclassified

Clinical and microbiological efficacy of "Bioplasmiх throat spray" in the treatment of chronic inflammatory diseases of the palatine tonsils

Bezshapochny¹,

Polianskaya²,

Zachepylo³

2021

OTORHINOLARYNGOLOGY

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Topicality: Chronic inflammatory diseases of the tonsils occupy a significant place in the structure of otorhinolaryngological pathology. The transition of inflammation to a chronic form is associated with the suppression of factors of colonization resistance of this biotope, the emergence of pathogenic microorganisms such as St. рyogenes and S. aureus. Аgainst the background of developing dysbiosis and immune imbalance, a number of complications from organs and systems may develop. Therefore, the search for means for effective topical etiotropic treatment of chronic tonsillitis and, at the same time, gentle on the indigenous microflora, is relevant. Materials and methods: The study involved 52 patients with chronic tonsillitis. All patients were divided into 2 groups of 26 each. Subjects of the 1st group in local therapy used the bacterial component "Bioplasmix throat spray", and patients in the 2nd group – used the traditional course of treatment: washing the lacunae of the tonsils with antiseptic agent – decamethoxine at a concentration of 0.2 mg/ml. Results and discussion: Studies have shown the selective antimicrobial activity of "Bioplasmix Throat Spray". Thus, in relation to the main pathogens "Bioplasmix Throat Spray" showed a pronounced antibacterial effect and, at the same time, helped to normalize the population level of indigenous microflora, which indicates the restoration of colonization resistance of the biotope. The positive dynamics of the main complaints of patients and pharyngoscopic signs testified to the clinical effectiveness of "Bioplasmiх Throat Spray". The analysis of clinical indicators in patients of the 2nd group showed a decrease in the severity of patient complaints and objective signs of the disease during treatment with decamethoxine. The results of repeated microbiological studies showed that, unlike "Bioplasmiх Throat Spray", the broad spectrum of antimicrobial action of decamethoxine does not contribute to the restoration and maintenance of high population levels of indigenous microflora of thepalatine tonsils.

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The specific pathogenetic features of the development of chronic tonsillar pathology

Pal'chun

Гуров

Гусева

2018

Vestn. otorinolaringol.

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The authors discuss the mechanisms underlying the development of chronic tonsillar pathology confirmed by the methods of histological, autoradiographic, and bacteriological diagnostics. The new aspects of vital activity of microorganisms in the parenchymal tissue of the palatine tonsils are highlighted that account for the low effectiveness of the conservative therapy of chronic tonsillitis and give evidence of the necessity of the surgical treatment of this condition.

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The post-streptococcal diseases in the clinical practice

Cited by 8 publications

References 16 publications

Predictors of cardiovascular events in patients with heart failure and <i>Pseudomonas aeruginosa</i> pneumonia

Predictors of cardiovascular events in patients with heart failure and <i>Pseudomonas aeruginosa</i> pneumonia

Clinical and microbiological efficacy of "Bioplasmiх throat spray" in the treatment of chronic inflammatory diseases of the palatine tonsils

The specific pathogenetic features of the development of chronic tonsillar pathology

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