The postweaning social isolation in C57BL/6 mice: preferential vulnerability in the male sex

Pietropaolo, Susanna; Singer, Philipp; Feldon, Joram; Yee, Benjamin K.

doi:10.1007/s00213-008-1081-3

Cited by 71 publications

(68 citation statements)

References 123 publications

(198 reference statements)

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“…A consistent pattern of results was replicated in experiment 2 (Table 1). Indeed, the lack of startle habituation in C57BL/6 mice is a robust result in agreement with earlier reports (Pietropaolo et al 2008;Yee et al 2004aYee et al , 2005. Given that impairment in startle reflex habituation is also present in schizophrenia patients and may be related to impaired selective attention (Geyer and Braff 1987;Geyer et al 1990), should one also consider this strain-specific trait as a potential schizophrenia-related endophenotype?…”

Section: Discussionsupporting

confidence: 75%

Are DBA/2 mice associated with schizophrenia-like endophenotypes? A behavioural contrast with C57BL/6 mice

2009

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Relative to the C57BL/6 strain, DBA/2 mice displayed multiple behavioural traits relevant to schizophrenia psycho- and physiopathology, indicative of both dopaminergic and glutamatergic/N-methyl-D: -aspartic acid receptor dysfunctions. Further examination of their underlying neurobiological differences is therefore warranted in order to enhance the power of this specific inter-strain comparison as a model of schizophrenia.

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Section: Discussionsupporting

confidence: 75%

Are DBA/2 mice associated with schizophrenia-like endophenotypes? A behavioural contrast with C57BL/6 mice

2009

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“…The mean startle reaction (ln-transformed) on the two blocks was as follows: first block: high-PPI = 4.23, low-PPI = 4.29, SE = .14; last block: high-PPI = 4.20, low-PPI = 4.47, SE = .15. The lack of clear startle habituation here was expected as we have repeatedly shown that C57BL/6 mice did not show reliable stable habituation (e.g., Pietropaolo, Singer, Feldon, & Yee, 2008;Singer, Feldon, & Yee, 2009b;Singer & Yee, 2012;Yee et al, 2004aYee et al, , 2005 in our laboratory. Singer et al (2013) reported that while some subjects (C57BL/6 mice) showed habituation, a similar number showed sensitization.…”

Section: Resultssupporting

confidence: 49%

Individual difference in prepulse inhibition does not predict spatial learning and memory performance in C57BL/6 mice

Peleg‐Raibstein

Singer

Feldon

et al. 2015

Cogn Affect Behav Neurosci

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The startle reflex to an intense acoustic pulse stimulus is attenuated if the pulse stimulus is shortly preceded by a weak non-startling prepulse stimulus. This attenuation of the startle reflex represents a form of pre-attentional sensory gating known as prepulse inhibition (PPI). Although PPI does not require learning, its expression is regulated by higher cognitive processes. PPI deficits have been detected in several psychiatric conditions including schizophrenia where they coexist with cognitive deficits. A potential link between PPI expression and cognitive performance has therefore been suggested such that poor PPI may predict, or may be mechanistically linked to, overt cognitive impairments. A positive relationship between PPI and strategy formation, planning efficiency, and execution speed has been observed in healthy humans. However, parallel studies in healthy animals are rare. It thus remains unclear what cognitive domains may be associated with, or orthogonal to, sensory gating in the form of PPI in healthy animals. The present study evaluated a potential link between the magnitude of PPI and spatial memory performance by comparing two subgroups of animals differing substantially in baseline PPI expression (low-PPI vs high-PPI) within a homogenous cohort of 100 male adult C57BL/6 mice. Assessment of spatial reference memory in the Morris water maze and spatial recognition memory in the Y-maze failed to reveal any difference between low-PPI and high-PPI subjects. These negative findings contrast with our previous reports that individual difference in PPI correlated with sustained attention and working memory performance in C57BL/6 mice.

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“…In a study of another AD model, and using physical exercise as intervention, Pietropaolo et al (2008) found the result to be influenced by gender. Stress per se, on the other hand, is a strong negative regulator of adult neurogenesis (Gould et al, 1997), whereas gender differences appear to be minimal.…”

Section: Discussionmentioning

confidence: 94%

Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease

Mirochnic¹,

et al. 2009

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An active lifestyle is to some degree protective against Alzheimer's disease (AD), but the biological basis for this benefit is still far from clear. We hypothesize that physical and cognitive activity increase a reserve for plasticity by increasing adult neurogenesis in the hippocampal dentate gyrus (DG). We thus assessed how age affects the response to activity in the murine APP23 model of AD compared with wild type (WT) controls and studied the effects of physical exercise (RUN) and environmental enrichment (ENR) in comparison with standard housing (CTR) at two different ages (6 months and 18 months) and in both genotypes. At 18 months, both activity paradigms reduced the hippocampal human Abeta1-42/Abeta1-40 ratio when compared with CTR, despite a stable plaque load in the hippocampus. At this age, both RUN and ENR increased the number of newborn granule cells in the DG of APP23 mice when compared with CTR, whereas the levels of regulation were equivalent to those in WT mice under the same housing conditions. At 6 months, however, neurogenesis in ENR but not RUN mice responded like the WT. Quantifying the number of cells at the doublecortin-positive stage in relation to the number of cells on postmitotic stages we found that ENR overproportionally increased the number of the DCX-positive "late" progenitor cells, indicative of an increased potential to recruit even more new neurons. In summary, the biological substrates for activity-dependent regulation of adult hippocampal neurogenesis were preserved in the APP23 mice. We thus propose that in this model, ENR even more than RUN might contribute to a "neurogenic reserve" despite a stable plaque load and that age affects the outcome of an interaction based on "activity."

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The postweaning social isolation in C57BL/6 mice: preferential vulnerability in the male sex

Abstract: We conclude that social isolation in mice represents a valuable tool for the examination of candidate genes within the context of the "two-hit" hypothesis of the aetiological processes in schizophrenia.

Cited by 71 publications

References 123 publications

Are DBA/2 mice associated with schizophrenia-like endophenotypes? A behavioural contrast with C57BL/6 mice

Are DBA/2 mice associated with schizophrenia-like endophenotypes? A behavioural contrast with C57BL/6 mice

Individual difference in prepulse inhibition does not predict spatial learning and memory performance in C57BL/6 mice

Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease

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