Negative potassium (K) balances on farmlands globally are widespread because fertiliser K input is often less than losses (leaching) and removal of K in hay, straw and grain, which leads to a rundown of plant-available K. When soil K reserves are not large and the plant-available K pools are not well buffered, the risk of K rundown in soils is high. In the south-west of Western Australia, soil K rundown, particularly by continuous cropping or in systems where a large portion of crop biomass is removed, is increasing the prevalence of crop K deficiency even on soils where K was not previously a limiting factor for crop yields. While fertiliser K is required for adequate supply of plant-available K, maximising K use efficiency is also important for cropping profitability and sustainability in dryland agriculture. Plant K uptake and use efficiency can be affected by soil types, crop species and sequences, seasonal conditions, and K management. In water-limited environments, crop K nutrition, especially root access to subsoil K, plays a crucial role in promoting root growth, regulating plant water relations and alleviating biotic and abiotic stresses. Optimised use of both soil and fertiliser K is increasingly necessary to sustain crop yields under stressed conditions in the context of K rundown in soils.