The potency of eriosematin E from Eriosema chinense Vogel. against enteropathogenic Escherichia coli induced diarrhoea using preclinical and molecular docking studies

Parmar, Komal M.; Bhagwat, Dhiraj S; Sinha, Saurabh; Katare, Nitin T.; Prasad, Shilpa

doi:10.1016/j.actatropica.2019.02.025

Cited by 10 publications

(2 citation statements)

References 33 publications

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“…Intestinal disorders often co-occur with inflammation and dysmotility. In enteropathogenic E. coli-induced diarrhea, 10 mg/kg of 81 from roots of E. chinense for 24 h significantly decreased the expression of pro-inflammatory cytokines IL-1β and TNF-α in colonic tissues (Parmar et al, 2019b).…”

Section: Anti-inflammatory Activitymentioning

confidence: 90%

“…Enteropathogenic E. coli (EPEC) is a common cause of moderate to severe water diarrhea in children, accompanied with fever, vomiting and a high hazard of death. In an enteropathogenic E. coli-induced diarrhea rat model, EEC (100 and 200 mg/kg), CEC (50 and 100 mg/kg) and 81 (5 and 10 mg/kg) induced a significant recovery from diarrhea characterized by the reduction in total number of stools, total number of diarrheal stools, weight of stools, mean defecation rate and water content of stools 6 h after induction of diarrhea (Parmar et al, 2019a;Parmar et al, 2019b). At the higher tested doses, EEC, CEC and eriosematin E displayed diarrhea scores very close to that of 5.7 mg/kg norfloxacin.…”

Section: Anti-diarrheal Activitymentioning

confidence: 99%

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The Genus Eriosema (Fabaceae): From the Ethnopharmacology to an Evidence-Based Phytotherapeutic Perspective?

2021

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The genus Eriosema (Fabaceae) includes approximately 150 species widely distributed across tropical and subtropical regions of the world (Africa, Neotropics, Asia and Australia). Throughout these regions, several species are used since centuries in different traditional medicinal systems, while others are used as food or food supplement. The present review attempts to critically summarize current information concerning the uses, phytochemistry and pharmacology of the Eriosema genus and to evaluate the therapeutic potential. The information published in English and French (up to September 2020) on ethnopharmacology or traditional uses, chemistry, pharmacology and toxicology of Eriosema genus was collected from electronic databases [SciFinder, PubMed, Google, Google Scholar, Scopus, Web of Science, Prelude Medicinal Plants—http://www.ethnopharmacologia.org/recherche-dans-prelude/?plant, The Plant List (http://www.theplantlist.org/), POWO (http://powo.science.kew.org/) and IUCN Red List Categories (https://www.iucnredlist.org/)], conference proceedings, books, M.Sc. and Ph.D. dissertations. The information retrieved on the ethnomedicinal indications of Eriosema genus allowed to list 25 species (∼16.6% of the genus). The majority of uses is recorded from Africa. Phytochemical analyses of 8 species led to the identification and/or isolation of 107 compounds, with flavonoids (69.2%), chromones (7.5%) and benzoic acid derivatives (3.7%) as the main chemical classes. Pharmacological investigations with crude extracts and isolated compounds showed a broad range of activities including aphrodisiac, estrogenic, anti-osteoporosis, hypolipidemic, anti-diabetic, anti-diarrheal, anti-microbial, anti-oxidant, anthelmintic, anti-cancer, and acetylcholinesterase inhibitory activities. Despite the low number of Eriosema species tested, there is convincing evidence in vitro and in vivo studies validating some traditional and ethnobotanical uses. However, the utility of several of the described uses has not yet been confirmed in pharmacological studies. Reviewed data could serve as a reference tool and preliminary information for advanced research on Eriosema species.

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Section: Anti-inflammatory Activitymentioning

confidence: 90%

Section: Anti-diarrheal Activitymentioning

confidence: 99%