The Potential Benefits and Inherent Risks of Vibration as a Non-Drug Therapy for the Prevention and Treatment of Osteoporosis

Chan, M. Ete; Uzer, Gunes; Rubin, Clinton T.

doi:10.1007/s11914-012-0132-1

Cited by 56 publications

(74 citation statements)

References 73 publications

(79 reference statements)

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“…Acceleration has been proposed as an alternate mechanical signal sensed by cells during LMHF vibration 13,55 . However, results here show that acceleration varied little with the loaded samples; a minimum value within the marrow was found to be 0.15 g, with the majority of the marrow experiencing the applied 0.3 g. Therefore, trying to determine whether a relationship between bone formation, or other parameters, and acceleration exists was not possible with the current results.…”

Section: Discussionmentioning

confidence: 99%

Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants

et al. 2014

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Low magnitude high frequency (LMHF) loading has been shown to have an anabolic effect on trabecular bone in vivo. However, the precise mechanical signal imposed on the bone marrow cells by LMHF loading, which induces a cellular response, remains unclear. This study investigates the influence of LMHF loading, applied using a custom designed bioreactor, on bone adaptation in an explanted trabecular bone model, which isolated the bone and marrow.Bone adaptation was investigated by performing micro CT scans pre and post experimental LMHF loading, using image registration techniques. Computational fluids dynamics models were generated using the pre-experiment scans to characterise the mechanical stimuli imposed by the loading regime prior to adaptation. Results here demonstrate a significant increase in bone formation in the LMHF loaded group compared to static controls and media flow groups.The calculated shear stress in the marrow was between 0.575 and 0.7 Pa, which is within the range of stimuli known to induce osteogenesis by bone marrow mesenchymal stem cells in vitro. Interestingly, a correlation was found between the bone formation balance (bone formation/resorption), trabecular number, trabecular spacing, mineral resorption rate, bone resorption rate and mean shear stresses. The results of this study suggest that the magnitude of the shear stresses generated due to LMHF loading in the explanted bone cores, has a contributory role in the formation of trabecular bone and improvement in bone architecture parameters.3

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Section: Discussionmentioning

confidence: 99%

Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants

et al. 2014

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“…Studies have reported that mechanical signals are directly recognized by mesenchymal stem cells (MSCs), and serve to promote osteoblastogenesis and inhibit adipogenesis, even under environmental conditions inducing fat formation (Chan et al. ). Despite general agreement that mechanical signals play a central role in fat distribution, the ideal characteristics of an effective loading regimen or the molecular cues that control the adaptive responses are still poorly understood (Engler et al.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we investigated the effects of ET associated with low-intensity and high-frequency MV on bone tissue of osteopenic female mice, a classic animal model of postmenopausal osteoporosis (Nakamura et al 2007;Li et al 2010;Syed et al 2010;Ozturan et al 2011;Chan et al 2013;Florencio-Silva et al 2013;Santos et al 2014;Pacheco-Costa et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Estrogen therapy associated with mechanical vibration improves bone microarchitecture and density in osteopenic female mice

et al. 2018

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We investigated the effects of estrogen therapy (ET) associated with low‐intensity and high‐frequency mechanical vibration (MV) on bone tissue in osteopenic female mice. Fifty 3‐month‐old female Swiss mice were ovariectomized (OVX) or sham‐operated, and distributed after 4 months into the following groups, with 10 animals per group: Sham; Control, OVX + vehicle solution; MV, OVX + MV; ET, OVX + 17β‐estradiol; and MV + ET, OVX + MV and 17β‐estradiol. Both vehicle solution and 17β‐estradiol (10 μg kg−1 day−1) were injected subcutaneously 7 days per week, and vibration (0.6 g, 60 Hz) was delivered 30 min per day, 5 days per week. Bone mineral density (BMD) and body composition were evaluated by densitometry at baseline and after 60 days of treatment when the animals were euthanized, and their femurs underwent histomorphometric and histochemical analyses. The Control group showed increased weight and fat percentage, while the ET and MV + ET groups showed increased lean mass but decreased fat percentage. At the end of the treatment period, the BMD decreased in Control, remained constant in Sham and MV, and increased in ET and MV + ET. The MV + ET group showed the greatest bone volume compared with Sham (129%), Control (350%), MV (304%) and ET (14%). No differences occurred in cortical thickness. The Control group showed the highest content of mature collagen fibers, while the MV + ET group showed the highest content of immature collagen fibers. In conclusion, ET plus MV was effective in improving bone quality in osteopenic female mice, and this improvement is associated with specific changes in trabecular but not cortical bone.

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“…LMMS is thought to have the most robust effect on the skeleton before physical maturity [30]. Previous studies of individuals with cerebral palsy [31,32], thalassemia [33], post-menopausal osteoporosis [34][35][36], and young females with a history of fracture [37] have shown that LMMS increases BMD and improves bone quality and quantity.…”

Section: Lmms and Bone Healthmentioning

confidence: 99%

The effect of low magnitude mechanical stimulation (LMMS) on bone density in patients with Rett syndrome: A pilot and feasibility study

Afzal¹,

Wender

Jones³

et al. 2014

Journal of Pediatric Rehabilitation Medicine

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PURPOSE: Low magnitude mechanical stimulation (LMMS) has been used successfully to promote bone formation in certain patient populations. This study evaluated the feasibility and effectiveness of LMMS on improving bone mineral density (BMD) in patients with Rett syndrome. METHODS: A 12-month crossover pilot study design of 6 months of intervention with LMMS and 6 months without was studied in 14 subjects divided in two subgroups. BMD was assessed using Dual Energy X-ray Absorptiometry (DXA). The levels of 25-hydroxy vitamin D (25OHD), Parathyroid Hormone (PTH), Insulin-Like Growth Factor 1 (IGF-1), and circulating markers of bone resorption (NTx) were analyzed in blood samples. Health questionnaires and diet logs were obtained at 0, 6, and 12 months. RESULTS: Of the 11 subjects who completed the protocol, 9 had an adherence of > 65% and showed an increase in spine BMD Z-scores from the intervention (Z: −2.51) compared to non-intervention period (Z: −2.27) of 0.23 SD (p = 0.048). Following intervention, favorable trends were also observed for IGF-1 (p = 0.06) and right distal femur BMD Z-scores (p = 0.07). CONCLUSIONS: These preliminary results are promising for a larger, placebo-controlled randomized study of subjects with Rett syndrome.

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The Potential Benefits and Inherent Risks of Vibration as a Non-Drug Therapy for the Prevention and Treatment of Osteoporosis

Cited by 56 publications

References 73 publications

Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants

Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants

Estrogen therapy associated with mechanical vibration improves bone microarchitecture and density in osteopenic female mice

The effect of low magnitude mechanical stimulation (LMMS) on bone density in patients with Rett syndrome: A pilot and feasibility study

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