The potential effect of Wuqinxi exercise for primary osteoporosis: A systematic review and meta-analysis

Wei, Xu; Ai-li, XU; Yin, Yue-Ping; Zhang, Ranxing

doi:10.1016/j.maturitas.2015.08.013

Cited by 32 publications

(35 citation statements)

References 42 publications

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“…Data were extracted from 1 review of systematic reviews, 17 systematic reviews, 1 narrative review, 20 RCTs, one quasi-RCT and 3 non-randomised studies. Meta-analyses for outcomes of interest were available in 9 papers,24–32 with participant numbers from 11624 to 19 519 25. Sample size of primary studies varied from 6229 participants33 to 70 participants 34.…”

Section: Resultsmentioning

confidence: 99%

Prevention and management of osteoporotic fractures by non-physician health professionals: a systematic literature review to inform EULAR points to consider

et al. 2020

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ObjectiveTo perform a systematic literature review (SLR) about the effect of non-pharmacological interventions delivered by non-physician health professionals to prevent and manage osteoporotic fractures.MethodsEight clinical questions based on two criteria guided the SLR: (1) adults≥50 years at high risk of osteoporotic fracture and (2) interventions delivered by non-physician health professionals to prevent and manage osteoporotic fractures. Interventions focused on diagnostic procedures to identify risk of falling, therapeutic approaches and implementation strategies. Outcomes included fractures, falls, risk of falling and change in bone mineral density. Systematic reviews and randomised controlled trials were preferentially selected. Data were synthesised using a qualitative descriptive approach.ResultsOf 15 917 records, 43 articles were included. Studies were clinically and methodologically diverse. We identified sufficient evidence that structured exercise, incorporating progressive resistance training delivered to people who had undergone hip fracture surgery, and multicomponent exercise, delivered to people at risk of primary fracture, reduced risk of falling. The effectiveness of multidisciplinary fracture liaison services in reducing refracture rate was confirmed. There was insufficient evidence found to support the effectiveness of nutrients and falls prevention programmes in this patient population.ConclusionDespite study heterogeneity, our SLR showed beneficial effects of some interventions delivered by non-physician health professionals and the positive impact of multidisciplinary team working and patient educational approaches to prevent and manage osteoporotic fractures. These results informed a EULAR taskforce that developed points to consider for non-physician health professionals to prevent and manage osteoporotic fractures.

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Section: Resultsmentioning

confidence: 99%

Prevention and management of osteoporotic fractures by non-physician health professionals: a systematic literature review to inform EULAR points to consider

et al. 2020

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“…Second, the majority of studies failed to report the random method, did not use blinding, did not describe the number and the reason of withdrawal, and did not register the study protocol. Similar to the several systematic reviews of alternative medicine for osteoporosis, the methodological quality of RCTs is the major problem affecting the efficacy evaluation 42,43. The researchers of Chinese medicine should attach more importance to improve reporting quality using the Consolidated Standards of Reporting Trials (CONSORT) statement 44.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review

Jia

Chai

et al. 2017

CIA

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PurposeThe aim is to systematically assess the effectiveness and safety of Chinese herbal formula Erxian decoction (EXD) for treating osteoporosis.Materials and methodsSix databases were searched from inception through September 17, 2016, without language restriction. All randomized controlled trials of EXD for osteoporosis were included. One or more outcome measures including fracture, change in bone mineral density (BMD), pain symptom improvement, bone biochemical markers, quality of life, adverse event or adverse drug reaction were evaluated. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards.ResultsEight trials including 644 patients investigated the effects of EXD in the treatment of osteoporosis. The methodological quality of the included trials was generally low. The meta-analysis from two trials showed favorable effects of EXD in improving BMD of lumbar spine (mean difference [MD]: 0.05 [0.03, 0.06]; I2=0%; P<0.00001) and BMD of femoral great trochanter (MD: 0.06 [0.02, 0.10]; I2=59%; P=0.005) compared with caltrate tablets. The other meta-analysis from two trials showed beneficial effects of EXD plus caltrate tablets and calcitriol in improving BMD of femoral neck (MD: 0.04 [0.00, 0.09]; I2=56%; P=0.04), the level of calcium (MD: 0.20 [0.15, 0.24]; I2=0%; P<0.00001), and phosphorus (MD: −0.28 [−0.39, −0.17]; I2=68%; P<0.00001) compared with caltrate tablets and calcitriol alone. The adverse drug reactions of EXD were mainly slight gastrointestinal symptoms.ConclusionThe study provides suggestive evidence of the superiority of EXD monotherapy or combination therapy over basic supplements for treating osteoporosis. However, the evidence remains weak. More rigorously designed and measured, randomized double-blind, placebo-controlled trials with larger sample size are needed to verify the current conclusions.

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“…Medication and functional exercise remains the mainstay for the treatment of osteoporosis [44–48]. In the included 13 trials, different type of moxibustion is almost applied as a complementary treatment method.…”

Section: Discussionmentioning

confidence: 99%

Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials

Huang

Kong

et al. 2017

PLoS ONE

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Primary osteoporosis (POP) has a serious impact on quality of life for middle-aged and elderly, which particularly increase the risk of fracture. We conducted the systematic review to evaluate the effects of moxibustion for POP in randomized controlled trials (RCTs).Eight databases were searched from their inception to July 30, 2016. The RCTs reporting the moxibustion as a monotherapy or in combination with conventional therapy for POP were enrolled. The outcomes might be fracture incidence, quality of life, clinical symptoms, death attributed to osteoporosis, adverse effect, bone mineral density (BMD), and biochemical indicators. Literature selection, data abstraction, quality evaluation, and data analysis were in accordance with Cochrane standards.Thirteen trials including 808 patients were included. Meta-analysis was not conducted because of the obvious clinical or statistical heterogeneity. Limited evidence suggested that moxibustion plus anti-osteoporosis medicine might be more effective in relieving the pain (visual analogue scale scores average changed 2 scores between groups, 4 trials), increasing the BMD of femoral neck (average changed 0.4 g/cm2 between groups, 3 trials), and improving the level of bone gla protein, osteoprotegerin and bone alkaline phosphatase (2 trials) compared with anti-osteoporosis medicine alone. However, the quality of previous studies was evaluated as generally poor. The safety evidence of moxibustion was still insufficient. Due to the paucity of high-quality studies, there was no definite conclusion about the efficacy and safety of moxibustion treating POP although parts of positive results were presented. Future research should pay attention to the dose-response relation and fracture incidence of moxibustion for POP.

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The potential effect of Wuqinxi exercise for primary osteoporosis: A systematic review and meta-analysis

Cited by 32 publications

References 42 publications

Prevention and management of osteoporotic fractures by non-physician health professionals: a systematic literature review to inform EULAR points to consider

Prevention and management of osteoporotic fractures by non-physician health professionals: a systematic literature review to inform EULAR points to consider

Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review

Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials

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