The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases

Anchang, C. G.; Xu, Cong; Raimondo, Maria Gabriella; Atreya, Raja; Maier, Andreas; Schett, Georg; Zaburdaev, Vasily; Rauber, Simon; Ramming, Andreas

doi:10.3390/ijms22147506

Cited by 7 publications

(4 citation statements)

References 112 publications

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“…In the emerging field of omics of sepsis, we believe that this review will provide an initial summary of the literature in the field as a resource and also encourage further studies (8,9,10,11). In particular, as sepsis is a complex process, proteomics provides a quantitative analysis of the protein changes that can help bridge the genotype-phenotype gap (12).…”

Section: Introductionmentioning

confidence: 96%

Omics of endothelial cell dysfunction in sepsis

et al. 2022

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During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, resulting in increased permeability and excessive recruitment of leukocytes. Vascular endothelial cells share many common properties but have organ-specific phenotypes with unique structure and function. Thus, therapies directed against endothelial cell phenotypes are needed to address organ-specific endothelial cell dysfunction. Omics allow for the study of expressed genes, proteins and/or metabolites in biological systems and provide insight on temporal and spatial evolution of signals during normal and diseased conditions. Proteomics quantifies protein expression, identifies protein–protein interactions and can reveal mechanistic changes in endothelial cells that would not be possible to study via reductionist methods alone. In this review, we provide an overview of how sepsis pathophysiology impacts omics with a focus on proteomic analysis of mouse endothelial cells during sepsis/inflammation and its relationship with the more clinically relevant omics of human endothelial cells. We discuss how omics has been used to define septic endotype signatures in different populations with a focus on proteomic analysis in organ-specific microvascular endothelial cells during sepsis or septic-like inflammation. We believe that studies defining septic endotypes based on proteomic expression in endothelial cell phenotypes are urgently needed to complement omic profiling of whole blood and better define sepsis subphenotypes. Lastly, we provide a discussion of how in silico modeling can be used to leverage the large volume of omics data to map response pathways in sepsis.

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Section: Introductionmentioning

confidence: 96%

Omics of endothelial cell dysfunction in sepsis

et al. 2022

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“…Immunotherapy cannot be stopped, since the restoration of immune function is impossible, and the control of inflammation must be addressed throughout the life course. Despite this, the proportion of patients who respond to the standard of care is 40–60% [ 109 ]. Increasing scientific evidence indicates that pharmacological therapy is more effective if a healthy diet accompanies it; so, it would be interesting to have the support of other professionals, such as nutritionists.…”

Section: Imid Treatments and Their Optimization From The Pniementioning

confidence: 99%

Immune-Mediated Diseases from the Point of View of Psychoneuroimmunoendocrinology

Ortega

García-Montero

Fraile-Martínez

et al. 2022

Biology

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Immune-mediated inflammatory diseases (IMIDs) represent a large group of diseases (Crohn’s, ulcerative colitis, psoriasis, lupus, and rheumatoid arthritis) evidenced by systemic inflammation and multiorgan involvement. IMIDs result in a reduced quality of life and an economic burden for individuals, health care systems, and countries. In this brief descriptive review, we will focus on some of the common biological pathways of these diseases from the point of view of psychoneuroimmunoendocrinology (PNIE). PNIE consists of four medical disciplines (psychology, nervous system, immune system, and endocrine system), which are key drivers behind the health–disease concept that a human being functions as a unit. We examine these drivers and emphasize the need for integrative treatments that addresses the disease from a psychosomatic point of view.

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“…The incidence of IMIDs is growing in industrial societies; environmental changes combined with a genetic background trigger the development of IMIDs [4][5][6]. Recent evidence underpins the presence of shared common pathways among IMIDs [2,6,7], but knowledge of the immune factors that drive these chronic progressive diseases is still incomplete.…”

Section: Introductionmentioning

confidence: 99%

Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

Rusiñol,

Puig

2024

IJMS

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Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. However, the exact immune factors driving these chronic, progressive diseases are not fully understood. By using multi-omics techniques in cutaneous IMIDs, it is expected to advance the understanding of skin biology, uncover the underlying mechanisms of skin conditions, and potentially devise precise and personalized approaches to diagnosis and treatment. We provide a narrative review of the current knowledge in genomics, epigenomics, and proteomics of atopic dermatitis and psoriasis. A literature search was performed for articles published until 30 November 2023. Although there is still much to uncover, recent evidence has already provided valuable insights, such as proteomic profiles that permit differentiating psoriasis from mycosis fungoides and β-defensin 2 correlation to PASI and its drop due to secukinumab first injection, among others.

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The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases

Cited by 7 publications

References 112 publications

Omics of endothelial cell dysfunction in sepsis

Omics of endothelial cell dysfunction in sepsis

Immune-Mediated Diseases from the Point of View of Psychoneuroimmunoendocrinology

Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

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