The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs

Ostróżka-Cieślik, Aneta

doi:10.3390/polym14163307

Cited by 7 publications

(7 citation statements)

References 147 publications

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“…Carbomer (trade name: Carbopol) is a polymer available in several different grades, which differ in terms of the percentage content of crosslinking agents. It allows the preparation of stable hydrogels in acidic and basic environments [34]. It has mucoadhesive properties.…”

Section: Resultsmentioning

confidence: 99%

Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing

Ostróżka-Cieślik,

Przybyła,

Wójcik

et al. 2023

The 2nd International Electronic Conference on Biomedicines

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Section: Resultsmentioning

confidence: 99%

Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing

Ostróżka-Cieślik,

Przybyła,

Wójcik

et al. 2023

The 2nd International Electronic Conference on Biomedicines

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“…Hydrogels using cellulose derivatives as hormone carriers (testosterone, proges-terone, insulin, estradiol) are known to be used [49]. MC, sodium carboxymethylcellulose (CMC) and hydroxypropylmethylcellulose (HPMC) have been used to obtain hydrogels.…”

Section: Discussionmentioning

confidence: 99%

Somatotropin Penetration Testing from Formulations Applied Topically to the Skin

et al. 2023

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Growth hormone (somatotropin—STH) deficiency therapy requires daily injections of recombinant human growth hormone. The FDA approved treatment with STH with one dose per week for the first time in 2021. However, injectable drug application is accompanied by numerous inconveniences. Therefore, an attempt was made to formulate a less invasive STH formulation for topical application to the skin. A substrate was prepared based on a polymer, methylcellulose (MC), into which STH was introduced at a concentration of 1 mg/g. Simultaneously, formulations were made with STH, to which albumin (ALB) was added at different concentrations: 0.1%, 0.2% and 0.5%. A test of the degree of STH permeation was carried out, as well as the effect of ALB on STH permeation parameters. Selected rheological properties of the formulations obtained were investigated. A test of STH permeation in simulated in vivo conditions through porcine skin indicated a relatively good bioavailability of over 80% and confirmed the effectiveness of MC as a carrier for growth hormone. ALB prolonged the STH penetration rate and increased the penetration degree of STH to 93%. The hydrogels obtained were found to be typical shear-thinning, thixotropic fluids.

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“…Incorporating penetration enhancers in hydrogels requires a careful balance between optimizing permeation and ensuring safety and biocompatibility. It is crucial to tailor the choice of enhancers and their concentration based on the specific requirements of the intended application and the nature of the active ingredients being delivered [403]. Incorporating penetration enhancers into responsive hydrogels offers a promising avenue for improving drug delivery efficiency, especially in clinical applications where controlled and targeted release is crucial for therapeutic success.…”

Section: Incorporation Of Penetration Enhancersmentioning

confidence: 99%

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

Olteanu,

Neacșu,

Joița

et al. 2024

IJMS

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This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on the treatment of skin wounds. Regenerative hydrogels, composed mainly of water-absorbing polymers, have garnered attention in wound healing, particularly for skin wounds. Their unique properties make them well suited for tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist wound environment for optimal healing, and facilitating cell migration, and proliferation. Biocompatibility is a key feature, minimizing adverse reactions and promoting the natural healing process. Acting as a supportive scaffold for cell growth, hydrogels mimic the extracellular matrix, aiding the attachment and proliferation of cells like fibroblasts and keratinocytes. Engineered for controlled drug release, hydrogels enhance wound healing by promoting angiogenesis, reducing inflammation, and preventing infection. The demonstrated acceleration of the wound healing process, particularly beneficial for chronic or impaired healing wounds, adds to their appeal. Easy application and conformity to various wound shapes make hydrogels practical, including in irregular or challenging areas. Scar minimization through tissue regeneration is crucial, especially in cosmetic and functional regions. Hydrogels contribute to pain management by creating a protective barrier, reducing friction, and fostering a soothing environment. Some hydrogels, with inherent antimicrobial properties, aid in infection prevention, which is a crucial aspect of successful wound healing. Their flexibility and ability to conform to wound contours ensure optimal tissue contact, enhancing overall treatment effectiveness. In summary, regenerative hydrogels present a promising approach for improving skin wound healing outcomes across diverse clinical scenarios. This review provides a comprehensive analysis of the benefits, mechanisms, and challenges associated with the use of regenerative hydrogels in the treatment of skin wounds. In this review, the authors likely delve into the application of rational design principles to enhance the efficacy and performance of hydrogels in promoting wound healing. Through an exploration of various methodologies and approaches, this paper is poised to highlight how these principles have been instrumental in refining the design of hydrogels, potentially revolutionizing their therapeutic potential in addressing skin wounds. By synthesizing current knowledge and highlighting potential avenues for future research, this review aims to contribute to the advancement of regenerative medicine and ultimately improve clinical outcomes for patients with skin wounds.

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The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs

Cited by 7 publications

References 147 publications

Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing

Review of Research in Developing Hydrogels with Insulin to Promote Wound Healing

Somatotropin Penetration Testing from Formulations Applied Topically to the Skin

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

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