The potential protective influence of flaxseed oil against renal toxicity induced by thioacetamide in rats

Abstract

The present study was aimed to evaluate the influence of flaxseed oil on renal toxicity induced by thioacetamide in male rats. The animals were distributed into four groups. Rats of the first group were served as control. Rats of the second group were exposed to thioacetamide. Rats of the third group were treated with flaxseed oil and thioacetamide. Rats of the fourth group were treated with flaxseed oil. Significant increases of blood creatinine and uric acid were observed in TAA-treated rats after three weeks. In thioacetamide group, the levels of serum creatinine, blood urea nitrogen and uric acid were significantly elevated after six weeks. Histopathologically, the renal sections from thioacetamide-treated rats showed severe alterations in the structure of renal corpuscles including a degeneration of glomeruli and Bowman’s capsules. Administration of flaxseed oil protects the observed biochemical and histopathological alterations induced by thioacetamide exposure. Hence, the results of this study suggest that flaxseed oil protects against thioacetamide-induced renal injury and the protective influence of flaxseed oil may be attributed to its antioxidant role.

Inhibitory activity of flaxseed oil against CdCl2 induced liver and kidney damage: Histopathology, genotoxicity, and gene expression study

“…These findings imply that FO can block the inflammatory process and oxidative stress, which are responsible for CdCl 2 -induced toxicity. These observations support the down-regulation of TNF-α mRNA expression observed in the present work and are also in agreement with previous studies [ 21 , 22 , [31] , [32] , [33] ]. For example, Hendawi et al [ 34 ], found that oral administration of FO (0.5 g/kg) inhibited thiacloprid-induced liver histopathological damage in rats by promoting antioxidant defense system, decreasing lipid peroxidation, reducing proinflammatorycytokines, and stabilizing the DNA during cell division.…”

Effect of flaxseed oil on biochemical parameters, hormonal indexes and stereological changes in ovariectomized rats

“…Moneim et al showed that consumption of 1,000 mg/kg flaxseed oil in rats not only depicted no toxicity but also limit the renal cytotoxicity (Abdel Moneim et al., 2011). The other studies also confirm the potential protective influence of flaxseed oil against renal toxicity through alteration biochemical and histopathological factors (Shaikh Omar, 2018). These data confirmed the low toxicity and therapeutic potency of the mentioned oil.…”

Fortification of biscuit with sidr leaf and flaxseed mitigates immunosuppression and nephrotoxicity induced by cyclosporine A

“…This could be explained due to the presence of free radical scavengers and vitamin E contents in SL and FS which prevent hemolysis of red blood cells and lipid peroxidation (Anwar & Mohamed, 2010;El Kutry & Sopeah, 2020). Omar, 2018). Moreover, the antioxidant activity of SL and FS could inhibit and block the influence of oxidative renal damage induced by CsA (Almeer et al, 2019;Omar, 2018).…”

“…Omar, 2018). Moreover, the antioxidant activity of SL and FS could inhibit and block the influence of oxidative renal damage induced by CsA (Almeer et al, 2019;Omar, 2018). Cumulative data suggest that reactive oxygen molecules play a function as one of the postulated mechanisms for CsA nephrotoxicity (Toson et al, 2019).…”

“…In the current study, treatment with SL and FS ameliorate CsA-induced renal injury evident by reduction of oxidative stress and enhancement of the antioxidant status. This could be referred to their ability to upregulate the gene expression of various antioxidant enzymes suggesting their renal protective role (Almeer et al, 2020;Omar, 2018;Parikh et al, 2019;Rafa et al, 2019). Moreover, α-linolenic acid in flaxseed could mediate triggering of this antioxidant status against renal damage (Omar, 2018).…”