The potential role of chitosan‐based nanoparticles as drug delivery systems in pancreatic cancer

Sadoughi, Fatemeh; Mansournia, Mohammad Alì; Mirhashemi, Seyyed Mehdi

doi:10.1002/iub.2252

Cited by 23 publications

(13 citation statements)

References 96 publications

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“…Recently, this polymer has been used for the preparation of gene delivery carriers because chitosan is able to interact with DNA fragments and at acidic and neutral pHs it condenses DNA to nanoparticles, due to the presence of the amino groups [49]. Chitosan nanoparticles have also been used as a drug delivery system for therapeutic treatments of pancreatic cancer [50]. Furthermore, amino groups make the chitosan derivatization easy [51].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Nanoparticles for Therapy and Theranostics of Hepatocellular Carcinoma (HCC) and Liver-Targeting

et al. 2020

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Chitosan nanoparticles are well-known delivery systems widely used as polymeric carriers in the field of nanomedicine. Chitosan is a carbohydrate of natural origin: it is a biodegradable, biocompatible, mucoadhesive, polycationic polymer and it is endowed with penetration enhancer properties. Furthermore, it can be easily derivatized. Hepatocellular carcinoma (HCC) represents a remarkable health problem because current therapies, that include surgery, liver transplantation, trans-arterial embolization, chemoembolization and chemotherapy, present significant limitations due to the high risk of recurrence, to a lack of drug selectivity and to other serious side effects. Therefore, there is the need for new therapeutic strategies and for improving the liver-targeting to HCC. Nanomedicine consists in the use of nanoscale carriers as delivery systems to target and deliver drugs and/or diagnostic agents to specific organs or tissues. Chitosan and its derivatives can be successfully used in the preparation of nanoparticles that, for their peculiar surface-properties, can specifically interact with liver tumor, by passive and active targeting. This review concerns the use of chitosan nanoparticles for the therapy and theranostics of HCC and liver-targeting.

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Section: Introductionmentioning

confidence: 99%

Chitosan Nanoparticles for Therapy and Theranostics of Hepatocellular Carcinoma (HCC) and Liver-Targeting

et al. 2020

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“…Chitosan is an example of these natural compounds that is non-toxic and biocompatible [31]. Due to the flexibility of chitosan, researchers use it to design and manufacture various nanoparticles for drug delivery purposes [237].…”

Section: Discussionmentioning

confidence: 99%

Chitosan as possible inhibitory agents and delivery systems in leukemia

et al. 2021

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Leukemia is a lethal cancer in which white blood cells undergo proliferation and immature white blood cells are seen in the bloodstream. Without diagnosis and management in early stages, this type of cancer can be fatal. Changes in protooncogenic genes and microRNA genes are the most important factors involved in development of leukemia. At present, leukemia risk factors are not accurately identified, but some studies have pointed out factors that predispose to leukemia. Studies show that in the absence of genetic risk factors, leukemia can be prevented by reducing the exposure to risk factors of leukemia, including smoking, exposure to benzene compounds and high-dose radioactive or ionizing radiation. One of the most important treatments for leukemia is chemotherapy which has devastating side effects. Chemotherapy and medications used during treatment do not have a specific effect and destroy healthy cells besides leukemia cells. Despite the suppressing effect of chemotherapy against leukemia, patients undergoing chemotherapy have poor quality of life. So today, researchers are focusing on finding more safe and effective natural compounds and treatments for cancer, especially leukemia. Chitosan is a valuable natural compound that is biocompatible and non-toxic to healthy cells. Anticancer, antibacterial, antifungal and antioxidant effects are examples of chitosan biopolymer properties. The US Food and Drug Administration has approved the use of this compound in medical treatments and the pharmaceutical industry. In this article, we take a look at the latest advances in the use of chitosan in the treatment and improvement of leukemia.

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“…Additionally, ferulic acid in combination with PARP inhibitors has been reported to sensitize breast cancer cells, thus serving as an effective combination chemotherapeutic agent as a natural bioactive compound [ 66 ]. Furthermore, the potential role of a combination formula of ferulic acid and aspirin was also explored for pancreatic cancer chemoprevention, utilizing a new chitosan-coated solid lipid nanoparticles (c-SLN) drug delivery system encapsulating the natural compound and the drug; the results were found to be promising [ 67 ]. Moreover, a study including two different polyphenols, curcumin, and ferulic acid as adjuvant chemotherapeutics was carried out, evaluating chemoresistance and cisplatin-induced ototoxicity against chemotherapeutic regimes, such as cisplatin, for different types of cancers.…”

Section: Synergistic Interactions Of Ferulic Acid In Cancermentioning

confidence: 99%

Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling

Tuli

Kumar²,

Ramniwas

et al. 2022

Molecules

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Despite the immense therapeutic advances in the field of health sciences, cancer is still to be found among the global leading causes of morbidity and mortality. Ethnomedicinally, natural bioactive compounds isolated from various plant sources have been used for the treatment of several cancer types and have gained notable attention. Ferulic acid, a natural compound derived from various seeds, nuts, leaves, and fruits, exhibits a variety of pharmacological effects in cancer, including its proapoptotic, cell-cycle-arresting, anti-metastatic, and anti-inflammatory activities. This review study presents a thorough overview of the molecular targets and cellular signaling pathways modulated by ferulic acid in diverse malignancies, showing high potential for this phenolic acid to be developed as a candidate agent for novel anticancer therapeutics. In addition, current investigations to develop promising synergistic formulations are also discussed.

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The potential role of chitosan‐based nanoparticles as drug delivery systems in pancreatic cancer

Cited by 23 publications

References 96 publications

Chitosan Nanoparticles for Therapy and Theranostics of Hepatocellular Carcinoma (HCC) and Liver-Targeting

Chitosan Nanoparticles for Therapy and Theranostics of Hepatocellular Carcinoma (HCC) and Liver-Targeting

Chitosan as possible inhibitory agents and delivery systems in leukemia

Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling

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