The Power of the Shared Experience: MTN-020/ASPIRE Trial Participants’ Descriptions of Peer Influence on Acceptability of and Adherence to the Dapivirine Vaginal Ring for HIV Prevention

Katz, Ariana; Naidoo, Kalendri; Reddy, Krishnaveni; Chitukuta, Miria; Nabukeera, Josephine; Siva, Samantha; Zimba, Chifundo; Montgomery, Elizabeth T.

doi:10.1007/s10461-020-02799-0

Cited by 15 publications

(11 citation statements)

References 49 publications

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“…Previous HIV or HIV prevention peer support interventions have focused on the use of peer modeling or peer support, often with peers who do not necessarily know each other outside of the peer support activity (Baron et al, 2020; Embleton et al, 2019). Our findings suggest that the type of peer relationship matters for the strength and type of influence outcome, corroborating previous findings on peer influence within an HIV prevention clinical trial (Katz et al, 2020). Lack of support from friend groups has also been described in other HIV prevention studies in sub-Saharan Africa (Giovenco et al, 2021; Katz et al, 2020).…”

Section: Discussionsupporting

confidence: 91%

Qualitative Analysis Using Social Maps to Explore Young Women's Experiences With Social Support of their Oral PrEP Use in Kenya and South Africa

Katz

Roberts

Rousseau

et al. 2022

J Assoc Nurses AIDS Care

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Daily oral pre-exposure prophylaxis (PrEP) adherence is challenging. We explored African adolescent girls and young women's (AGYW) perceptions of the social influencers of their PrEP use and the social influencers' PrEP knowledge and support (six focus group discussions; 33 South African and Kenyan AGYW) in the Prevention Options for Women Evaluation Research demonstration project. Participants completed a social mapping exercise indicating strength and direction of influence of members in their social networks. Mothers and counselors were identified as positive influencers and most influential by .50% of participants, sex partners were labeled negative influencers or both positive and negative, and best friends were mostly positive influencers. HIV-and PrEPrelated stigma were the major reasons influencers were identified as negative. Participants wanted their social networks to be better educated about PrEP by someone other than the AGYW themselves (e.g., clinic staff) and to support their PrEP use. To improve PrEP adherence, community-and peer-based PrEP sensitization and delivery interventions should be evaluated.

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Section: Discussionsupporting

confidence: 91%

Qualitative Analysis Using Social Maps to Explore Young Women's Experiences With Social Support of their Oral PrEP Use in Kenya and South Africa

Katz

Roberts

Rousseau

et al. 2022

J Assoc Nurses AIDS Care

Self Cite

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“…Implementation strategies include client-centered counseling with supervision and fidelity monitoring; DVR alongside a package of clinic-based HIV and STI services; and DVR delivery in adolescent-friendly settings with peer support interventions (see Fig. 4 for strategies and their mechanisms of action) [10 ▪▪ ,53,57–60]. Although this work is still nascent, it remind us of the ways in which contextual factors and implementation decisions can impact DVR use and effectiveness [61].…”

Section: Review Of the Literaturementioning

confidence: 99%

Advancing considerations of context in the evaluation and implementation of evidence-based biomedical HIV prevention interventions: a review of recent research

Velloza¹,

Roche²,

Concepcion³

et al. 2022

Current Opinion in HIV and AIDS

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Purpose of review A paradigm shift is needed in how we think about biomedical HIV prevention product effectiveness. Often, we expect randomized trial findings to be generalizable across populations and settings where products will be delivered, without consideration of key contextual drivers that could impact effectiveness. Moreover, researchers and policy-makers generally discount products with varied effect sizes across contexts, rather than explicating the drivers of these differences and using them to inform equitable product choice and delivery. We conducted a review of the recent HIV prevention research to advance considerations of context in choices of when, why, and how to implement biomedical HIV prevention products, with a particular focus on daily oral preexposure prophylaxis (PrEP) and the dapivirine vaginal ring (DPV). Recent findings Findings across recent studies of PrEP and DPV emphasize that products that do not work well in one context might be highly desirable in another. Key contextual drivers of PrEP and DPV effectiveness, use, and implementation include population, health system, cultural, and historical factors. We recommend conceptualization, measurement, and analysis approaches to fully understand the potential impact of context on prevention product delivery. Execution of these approaches has real-world implications for HIV prevention product choice and could prevent the field from dismissing biomedical HIV prevention products based on trial findings alone. Summary Ending the HIV epidemic will require tailored, person-centered, and equitable approaches to design, implement, and evaluate HIV prevention products which necessitates considerations of context in ongoing research and implementation.

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“…However, their formulation as a vaginal microbicide has been studied (Notario‐Perez et al, 2019; Notario‐Perez et al, 2020; Patki et al, 2020). Despite the microbicide formulation's progress, and most vaginal drugs have been in the form of gels, vaginal rings have gained acceptance in the last years due to a controlled release for a long time (Bunge et al, 2020; Katz et al, 2020; Roberts et al, 2020; Thurman et al, 2019; Vincent et al, 2018). Recently, there has been a growing interest in alternative dosage forms such as nanogels (das Neves & Sarmento, 2015; Destache et al, 2016; Kovarova et al, 2015; Lai & He, 2016) or electrospun fibers (Tyo et al, 2017; Tyo et al, 2019).…”

Section: Vaginal Formulations: Development and Characterizationmentioning

confidence: 99%

Baseline and time‐updated factors in preclinical development of anionic dendrimers as successful anti‐HIV‐1 vaginal microbicides

Rodriguez-Izquierdo

Sepúlveda‐Crespo

Lasso³

et al. 2022

WIREs Nanomed Nanobiotechnol

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Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy, most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 (HIV-1) in human clinical trials. In vitro, ex vivo, and in vivo models must be optimized, considering the knowledge acquired from unsuccessful and successful clinical trials to improve the current gaps and the preclinical development protocols. To date, dendrimers are the only nanotool that has advanced to human clinical trials as topical microbicides to prevent HIV-1 transmission. This fact demonstrates the importance and the potential of these molecules as microbicides. Polyanionic dendrimers

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The Power of the Shared Experience: MTN-020/ASPIRE Trial Participants’ Descriptions of Peer Influence on Acceptability of and Adherence to the Dapivirine Vaginal Ring for HIV Prevention

Cited by 15 publications

References 49 publications

Qualitative Analysis Using Social Maps to Explore Young Women's Experiences With Social Support of their Oral PrEP Use in Kenya and South Africa

Qualitative Analysis Using Social Maps to Explore Young Women's Experiences With Social Support of their Oral PrEP Use in Kenya and South Africa

Advancing considerations of context in the evaluation and implementation of evidence-based biomedical HIV prevention interventions: a review of recent research

Baseline and time‐updated factors in preclinical development of anionic dendrimers as successful anti‐HIV‐1 vaginal microbicides

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