The PRC2 complex epigenetically silences GATA4 to suppress cellular senescence and promote the progression of breast cancer

Yu, Wenqian; Lin, Xiaona; Leng, Shuai; Hou, Yiming; Dang, Zhiqiao; Xue, Shishan; Li, Na; Zhang, Fengquan

doi:10.1016/j.tranon.2024.102014

Translational Oncology

2024

DOI: 10.1016/j.tranon.2024.102014

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The PRC2 complex epigenetically silences GATA4 to suppress cellular senescence and promote the progression of breast cancer

Wenqian Yu,

Xiaona Lin,

Shuai Leng

et al.

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2024

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Cited by 2 publications

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Deciphering the Landscape of GATA-Mediated Transcriptional Regulation in Gastric Cancer

Begolli,

Patouna,

Vardakas

et al. 2024

Antioxidants

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Gastric cancer (GC) is an asymptomatic malignancy in early stages, with an invasive and cost-ineffective diagnostic toolbox that contributes to severe global mortality rates on an annual basis. Ectopic expression of the lineage survival transcription factors (LS-TFs) GATA4 and 6 promotes stomach oncogenesis. However, LS-TFs also govern important physiological roles, hindering their direct therapeutic targeting. Therefore, their downstream target genes are particularly interesting for developing cancer-specific molecular biomarkers or therapeutic agents. In this work, we couple inducible knockdown systems with chromatin immunoprecipitation and RNA-seq to thoroughly detect and characterize direct targets of GATA-mediated transcriptional regulation in gastric cancer cells. Our experimental and computational strategy provides evidence that both factors regulate the expression of several coding and non-coding RNAs that in turn mediate for their cancer-promoting phenotypes, including but not limited to cell cycle, apoptosis, ferroptosis, and oxidative stress response. Finally, the diagnostic and prognostic potential of four metagene signatures consisting of selected GATA4/6 target transcripts is evaluated in a multi-cancer panel of ~7000 biopsies from nineteen tumor types, revealing elevated specificity for gastrointestinal tumors. In conclusion, our integrated strategy uncovers the landscape of GATA-mediated coding and non-coding transcriptional regulation, providing insights regarding their molecular and clinical function in gastric cancer.

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Deciphering the Landscape of GATA-Mediated Transcriptional Regulation in Gastric Cancer

Begolli,

Patouna,

Vardakas

et al. 2024

Antioxidants

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Gene Expression Regulation and the Signal Transduction of Programmed Cell Death

Saqirile,

Deng,

et al. 2024

CIMB

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Cell death is of great significance in maintaining tissue homeostasis and bodily functions. With considerable research coming to the fore, it has been found that programmed cell death presents in multiple modalities in the body, which is not only limited to apoptosis, but also can be divided into autophagy, pyroptosis, ferroptosis, mitotic catastrophe, entosis, netosis, and other ways. Different forms of programmed cell death have disparate or analogous characteristics with each other, and their occurrence is accompanied by multiple signal transduction and the role of a myriad of regulatory factors. In recent years, scholars across the world have carried out considerable in-depth research on programmed cell death, and new forms of cell death are being discovered continually. Concomitantly, the mechanisms of intricate signaling pathways and regulators have been discovered. More critically, cancer cells tend to choose distinct ways to evade cell death, and different tumors adapt to different manners of death. Therefore, targeting the cell death network has been regarded as an effective tumor treatment strategy for a long time. The objective of our paper is to review the signaling pathways and gene regulation in several typical types of programmed cell death and their correlation with cancer.

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The PRC2 complex epigenetically silences GATA4 to suppress cellular senescence and promote the progression of breast cancer

Cited by 2 publications

References 56 publications

Deciphering the Landscape of GATA-Mediated Transcriptional Regulation in Gastric Cancer

Deciphering the Landscape of GATA-Mediated Transcriptional Regulation in Gastric Cancer

Gene Expression Regulation and the Signal Transduction of Programmed Cell Death

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