The precision of predicting the time of onset of parturition in the bitch using the level of progesterone in plasma during the preparturient period

Cramer, K.G.M. De; Nöthling, J.O.

doi:10.1016/j.theriogenology.2017.11.018

Cited by 23 publications

(40 citation statements)

References 34 publications

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“…Serum progesterone concentrations towards the end of pregnancy can help clinicians to assess impending canine parturition (Rota et al, 2015;De Cramer and Nöthling, 2018), but our data show that the progesterone concentrations are not significantly different in the last three days of pregnancy. Other easy-to measure serum parameters could be useful to increase the accuracy of the diagnosis and CRP, that can be assayed in any facility having instruments for biochemistry serum analysis, could have represented an option.…”

Section: Discussioncontrasting

confidence: 58%

“…A precise prediction of impending parturition could be very useful in order to avoid long observation periods and it is critical when planning a cesarean section. Serum progesterone concentration declines towards the end of pregnancy (Onclin and Verstegen, 1997) and some cut-off values have been calculated; when P is lower than the cut-of value, parturition is likely to occur within a given time interval (Rota et al, 2015;De Cramer and Nöthling, 2018).…”

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confidence: 99%

“…However, large individual variability exists in progesterone concentration, particularly in the last days of pregnancy (Rota et al, 2015;De Cramer and Nöthling, 2018), and other easily measurable parameters that could mark the end of pregnancy would be very useful in clinical practice.…”

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confidence: 99%

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Evaluation of serum C-reactive protein concentration as a marker of impending parturition and correlation with progesterone profile in peri-partum bitches

Rota¹,

Milani²,

Contiero³

et al. 2019

Animal Reproduction Science

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C-reactive protein (CRP) is one of the major acute phase proteins in dogs; it is produced by the liver and rapidly increases in response to an inflammatory stimulus. The aim of this study was to measure CRP concentrations around parturition and to verify whether this protein could be useful, together with progesterone (P), to detect the end of pregnancy in bitches. CRP and P concentrations were measured on 66 serum samples from 28 healthy pregnant bitches, collected between-5 and +2 days from parturition. The effect of 'days from parturition', parity, and litter size on P and CRP concentration was analyzed. P and CRP values were significantly affected by 'days from parturition'. While P showed the expected decline during the last days of pregnancy, CRP concentration was above the normal range from the day of parturition onwards, beginning to increase at day-1. The CRP concentration profiles during the days around parturition have not been previously reported in the dog. However, the late rise and the low magnitude of increase make CRP difficult to use in clinical practice to assess the end of pregnancy in the bitch.

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Section: Discussioncontrasting

confidence: 58%

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confidence: 99%

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Evaluation of serum C-reactive protein concentration as a marker of impending parturition and correlation with progesterone profile in peri-partum bitches

Rota¹,

Milani²,

Contiero³

et al. 2019

Animal Reproduction Science

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“…F I G U R E 1 Variation in the biparietal diameter (BPD) among litters of newborn puppies F I G U R E 2 Variation of the range in biparietal diameter (BPD) within litters of puppies Concannon, McCann, & Temple, 1989;De Cramer & Nöthling, 2018b;England & Verstegen, 1996;Luz, Bertan, Binelli, & Lopes, 2006;Onclin & Verstegen, 1997;Veronesi et al, 2002). De Cramer and Nöthling (2018b) ). However, two bitches-not suffering from dystocia-that had a sharp rise in cortisol during the 6-12 hr before TCD (exceeding 240 nM at TCD) also had a sharp rise in P4 from 3 nM to 9.8 and 12.8 nM during the 6 hr before TCD.…”

Section: Plasma Concentration Of Progesteronementioning

confidence: 99%

Towards scheduled pre‐parturient caesarean sections in bitches

Cramer

Nöthling

2020

Reprod Domestic Animals

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Elective caesarean section (CS) is the safest means of delivering the litter in bitches in specific situations. Timeously performing elective pre-parturient CSs at a fixed time would be convenient and prevent emergency CSs and foetal demise. This review proposes a method of performing elective pre-parturient CSs which is safe for both the bitch and puppies. Brachycephaly, small litters and large litters, preceding litter delivered by CS and trial of labour after a preceding CS are identified as factors increasing the need for CS whereas emergency CS is identified as factor increasing foetal demise. The first day of cytological dioestrus more precisely predicts the day of onset of spontaneous parturition than the first day of the LH surge or the dates during oestrus on which progesterone (P4) first exceeds 6 nM or 16 nM. Foetal biparietal diameter at the time of onset of spontaneous parturition varies too much to accurately predict readiness for CS. During the last few days of gestation, P4 with cutoff concentrations at 15.8, 8.7 and 3.18 nM, but not plasma cortisol concentrations, hold promise as predictors of onset of parturition and when to perform pre-parturient CSs. A protocol associating medetomidine hydrochloride as premedicant with propofol as induction agent and sevoflurane as maintenance is safe for scheduled CS and yields good maternal and puppy survival rates at delivery, 2 hr and 7 days after CSs. Clinicians have to pay attention to the haematocrit of bitches at the time of cervical dilatation which is at the lower end of the normal reference ranges for non-pregnant dogs and to the decline in haematocrit during CS (as a proxy for blood loss) which is approximately 7% for both parturient (open cervix) and pre-parturient (closed cervix) CSs. Pre-parturient CSs can be scheduled and performed 57 days after onset of cytological dioestrus with puppy survival rates of 99%. Collectively, these studies provide a protocol to safely perform elective CSs in a large proportion of the obstetric population at a convenient time of the day but more research is required with larger numbers to establish whether this practice is routinely safe and safe in all breeds.

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“…This possible invagination can occur because the uterus is contractile (Gogny et al, 2010;Young, 2007) and assumes a tubular anatomical shape (Barbosa et al, 2013;Yeager & Concannon, 1990). Moreover, we believe that certain physiological conditions, such as the postpartum period, may contribute to the pathogenesis of uterine intussusception in bitches, since in this period, the uterine ligaments are distended and inhibition of uterine quiescence occurs by the decrease in progesterone concentrations (De Cramer & Nöthling, 2018;Gogny et al, 2010).…”

mentioning

confidence: 99%

Uterine intussusception in immediate postpartum in bitches

Angrimani¹,

Silva²,

Ilkiu³

et al. 2020

Braz. J. Vet. Res. Anim. Sci.

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Uterine intussusception is a rare condition in bitches. This study aimed to report an unusual case of prolapsed uterine intussusception in a female dog. A 2-year-old American Bully bitch was received with labor history of large fetus requiring manual traction. The animal presented mucosal prolapse through the vulva, unproductive contractions and abdominal discomfort. After partial correction of mucosal prolapse, the dog was referred to ovary-hysterectomy surgery to correct prolapsed mucosa. During the surgical procedure, surgeons observed that the uterine horns were invaginated into the uterine body, rotated, and the tissue was slightly devitalized and congested. As previously described, this condition occurred during the immediate postpartum period. Thus, we suggest that this period can be a facilitator for the establishment of uterine intussusception.

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The precision of predicting the time of onset of parturition in the bitch using the level of progesterone in plasma during the preparturient period

Cited by 23 publications

References 34 publications

Evaluation of serum C-reactive protein concentration as a marker of impending parturition and correlation with progesterone profile in peri-partum bitches

Evaluation of serum C-reactive protein concentration as a marker of impending parturition and correlation with progesterone profile in peri-partum bitches

Towards scheduled pre‐parturient caesarean sections in bitches

Uterine intussusception in immediate postpartum in bitches

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