The predictive prognostic values of serum interleukin-2, interleukin-6, interleukin-8, tumor necrosis factor-α, and procalcitonin in surgical intensive care unit patients

Yan, Yamin; Hu, Yan; Wang, Xiaorong; Yu, Zhenghong; Tang, Yingjia; Zhang, Yuxia; Wang, Pan

doi:10.21037/atm-20-6608

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…It has been reported that cytokines, such as TNF-α, are activated after surgical invasion and induce biological responses similar to sepsis. [25][26][27][28] Based on our results, we believe that SVEP1 gene expression may be associated with these cytokines. Although estrogen reportedly regulates the expression of SVEP1, 29 the exact mechanisms underlying the regulation of SVEP1 remain to be determined.…”

Section: Discussionmentioning

confidence: 57%

Sepsis decreases lung SVEP1 expression in a murine model

Kurita

Oami²,

Fujimura³

et al. 2023

F1000Res

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Background: Genome-wide association studies have identified sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing 1 (SVEP1) polymorphism as a genetic risk factor for sepsis, as well as acute coronary syndrome. However, research on the role of SVEP1 in systemic inflammation, such as surgical invasion and sepsis, remains insufficient. Therefore, we investigated SVEP1 gene expression and protein levels after surgical invasion and sepsis in mice. Methods: We compared the gene expression and protein levels of SVEP1 between the control (no surgery), sham operation model, and sepsis model with cecal ligation and puncture in mice. Samples were collected at 2, 6, and 24 h after surgery. Results: The lungs had high gene expression and protein production of SVEP1 at baseline. Sham operation and sepsis decreased SVEP1 gene expression in the lungs immediately after stimulation. Furthermore, sepsis significantly downregulated the gene expression compared with sham operation. Flow cytometric analysis showed that mice with sepsis had a significantly decreased percentage of CD31high / SVEP1high and lymphatic vessel endothelial receptor 1 (LYVE-1)high / SVEP1high cells and an increased percentage of CD45.2high / SVEP1high cells. Conclusions: Sepsis decreased SVEP1 gene expression in the lungs. Mice with sepsis had a decreased percentage of SVEP1high vascular and lymphatic endothelial cells and an increased percentage of SVEP1high hematopoietic cells.

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Section: Discussionmentioning

confidence: 57%

Sepsis decreases lung SVEP1 expression in a murine model

Kurita

Oami²,

Fujimura³

et al. 2023

F1000Res

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“…Metabolite lactate has been standardized for indications of sepsis and septic shock. Furthermore, studies have shown that the proinflammatory cytokines interleukin-6 and tumor necrosis factor-alpha can be used as markers to diagnose sepsis ( 13 , 14 ). Although patient blood culture is recommended for diagnosing the etiologic agent of sepsis, sepsis cannot be detected in most patients due to the low abundance of microorganisms in the bloodstream or because the organisms cannot be proliferated in conventional culture medium ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of biomarkers and the mechanisms of multiple trauma complicated with sepsis using metabolomics

Feng

Dai

Liu

et al. 2022

Front. Public Health

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Sepsis after trauma increases the risk of mortality rate for patients in intensive care unit (ICUs). Currently, it is difficult to predict outcomes in individual patients with sepsis due to the complexity of causative pathogens and the lack of specific treatment. This study aimed to identify metabolomic biomarkers in patients with multiple trauma and those with multiple trauma accompanied with sepsis. Therefore, the metabolic profiles of healthy persons designated as normal controls (NC), multiple trauma patients (MT), and multiple trauma complicated with sepsis (MTS) (30 cases in each group) were analyzed with ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS)-based untargeted plasma metabolomics using collected plasma samples. The differential metabolites were enriched in amino acid metabolism, lipid metabolism, glycometabolism and nucleotide metabolism. Then, nine potential biomarkers, namely, acrylic acid, 5-amino-3-oxohexanoate, 3b-hydroxy-5-cholenoic acid, cytidine, succinic acid semialdehyde, PE [P-18:1(9Z)/16:1(9Z)], sphinganine, uracil, and uridine, were found to be correlated with clinical variables and validated using receiver operating characteristic (ROC) curves. Finally, the three potential biomarkers succinic acid semialdehyde, uracil and uridine were validated and can be applied in the clinical diagnosis of multiple traumas complicated with sepsis.

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“…Mean interleukin (IL)-6 Levels in coronavirus disease 2019 (COVID-19) patients admitted for less than 7 d were significantly suppressed relative to those hospitalized for more than 7 d[ 7 ]. In our previous study, critically ill patients exhibited high levels of IL-2, IL-6, IL-8, and TNF-α in the first 24 h post-operatively, and this was associated with poor clinical outcomes[ 8 ]. Adverse outcomes are correlated with prolonged ICU LoS[ 3 ].…”

Section: Introductionmentioning

confidence: 99%

C-reactive protein as a non-linear predictor of prolonged length of intensive care unit stay after gastrointestinal cancer surgery

Yan¹,

Gao²,

Jin³

et al. 2022

World J Clin Cases

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BACKGROUND The relationship between C-reactive protein (CRP) levels and prolonged intensive care unit (ICU) length of stay (LoS) has not been well defined. AIM To explore the association between CRP levels at ICU admission and prolonged ICU LoS in gastrointestinal cancer (GC) patients after major surgery. METHODS A retrospective study was performed to quantify serum CRP levels and to establish their association with prolonged ICU LoS (≥ 72 h) in GC patients admitted to the ICU. Univariate and multivariate regression analyses were conducted, and restricted cubic spline curves with four knots (5%, 35%, 65%, 95%) were used to explore non-linearity assumptions. RESULTS A total of 408 patients were enrolled. Among them, 83 (20.3%) patients had an ICU LoS longer than 72 h. CRP levels were independently associated with the risk of prolonged ICU LoS [odds ratio (OR) 1.47, 95% confidence interval (CI) 1.00–2.17]. Restricted cubic spline analysis revealed a non-linear relationship between CRP levels and OR for the prolonged ICU LoS ( P = 0.035 for non-linearity). After the cut-off of 2.6 (log transformed mg/L), the OR for prolonged ICU LoS significantly increased with CRP levels. The adjusted regression coefficient was 0.70 (95%CI 0.31–1.57, P = 0.384) for CRP levels less than 2.6, whereas it was 2.43 (95%CI 1.39–4.24, P = 0.002) for CRP levels higher than 2.6. CONCLUSION Among the GC patients, CRP levels at ICU admission were non-linearly associated with prolonged ICU LoS in survivors. An admission CRP level > 2.6 (log transformed mg/L) was associated with increased risk of prolonged ICU LoS.

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The predictive prognostic values of serum interleukin-2, interleukin-6, interleukin-8, tumor necrosis factor-α, and procalcitonin in surgical intensive care unit patients

Cited by 6 publications

References 29 publications

Sepsis decreases lung SVEP1 expression in a murine model

Sepsis decreases lung SVEP1 expression in a murine model

Identification of biomarkers and the mechanisms of multiple trauma complicated with sepsis using metabolomics

C-reactive protein as a non-linear predictor of prolonged length of intensive care unit stay after gastrointestinal cancer surgery

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