The Predictive Prognostic Values of Serum TNF-<i>α</i>in Comparison to SOFA Score Monitoring in Critically Ill Patients

Yousef, Ahmed; Suliman, Ghada Abdulmomen

doi:10.1155/2013/258029

Cited by 17 publications

(11 citation statements)

References 14 publications

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“…This C-index was superior to the C-indices of APACHE II (0.72) and SOFA scores (0.68), the golden standards in evaluating the sepsis severity. The SOFA score is included in the new definition of sepsis (Sepsis-3) 18 , and previous studies demonstrated that SOFA score is a good indicator of prognosis in ICU-admitted critically ill patients, especially those with severe sepsis 19 – 21 . Conversely, Liu et al reported in their meta-analysis that PCT was associated with mortality in septic patients and can moderately predict sepsis mortality 6 .…”

Section: Discussionmentioning

confidence: 99%

Histidine-rich glycoprotein as a prognostic biomarker for sepsis

Kuroda

Ishii

Mihara

et al. 2021

Sci Rep

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Various biomarkers have been proposed for sepsis; however, only a few become the standard. We previously reported that plasma histidine-rich glycoprotein (HRG) levels decreased in septic mice, and supplemental infusion of HRG improved survival in mice model of sepsis. Moreover, our previous clinical study demonstrated that HRG levels in septic patients were lower than those in noninfective systemic inflammatory response syndrome patients, and it could be a biomarker for sepsis. In this study, we focused on septic patients and assessed the differences in HRG levels between the non-survivors and survivors. We studied ICU patients newly diagnosed with sepsis. Blood samples were collected within 24 h of ICU admission, and HRG levels were determined using an enzyme-linked immunosorbent assay. Ninety-nine septic patients from 11 institutes in Japan were included. HRG levels were significantly lower in non-survivors (n = 16) than in survivors (n = 83) (median, 15.1 [interquartile ranges, 12.7–16.6] vs. 30.6 [22.1–39.6] µg/ml; p < 0.01). Survival analysis revealed that HRG levels were associated with mortality (hazard ratio 0.79, p < 0.01), and the Harrell C-index (predictive power) for HRG was 0.90. These results suggested that HRG could be a novel prognostic biomarker for sepsis.

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Section: Discussionmentioning

confidence: 99%

Histidine-rich glycoprotein as a prognostic biomarker for sepsis

Kuroda

Ishii

Mihara

et al. 2021

Sci Rep

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“…This study, however, studied dogs at admission to an intensive care unit, regardless of the presenting signs and previous history, and can therefore not be easily compared with this cohort of emergency patients with SIRS. The role of TNF‐α as an early mediator of the acute phase response with rapid downregulation makes it a poor diagnostic and prognostic tool in human critical care patients as well …”

Section: Discussionmentioning

confidence: 99%

Inflammatory cytokine and C‐reactive protein concentrations in dogs with systemic inflammatory response syndrome

Gommeren

Desmas

García

et al. 2017

J Vet Emergen Crit Care

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Objective -To evaluate C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-␣) kinetics in dogs with a systemic inflammatory response syndrome (SIRS) presented to an emergency service. We hypothesized serum CRP concentrations would increase and vary during hospitalization, and would correlate with plasma IL-6 and TNF-␣ concentrations, vary in magnitude according to the underlying disease, and predict survival. Design -Prospective, observational, clinical study. Setting -University emergency department. Animals -Sixty-nine dogs with SIRS weighing over 5 kg who could tolerate the blood sampling. Interventions -Serum and plasma were collected (and stored at -80°C) at presentation (T0), after 6 (T6), 12 (T12), 24 (T24), and 72 (T72) hours, and at a follow-up visit at least 1 month after discharge (T1m). Underlying diseases were categorized as infection (I), neoplasia (N), trauma (T), gastric-dilation and volvulus (GDV), other gastrointestinal (GI), renal (R), and miscellaneous (M) disease. Measurements and Main Results -Serum CRP concentration was measured using a canine-specific immunoturbidimetric assay. Biologically active plasma IL-6 and TNF-␣ concentrations were assessed using bioassays. Forty-four dogs survived, 8 died, and 17 were euthanized. Nineteen dogs had follow-up visits. At T0, serum CRP concentration was above the reference interval in 73.1% (49/67), and was within the reference interval (0-141.9 nmol/L) throughout hospitalization in only 6% (4/67). Serum CRP concentrations were significantly higher (P < 0.0001) at T0 (882.9 ± 1082.9 nmol/L) and at all time points during hospitalization (P < 0.0001) compared to T1m, with highest concentrations observed at T24 (906. 7 ± 859.0 nmol/L). At T1m, serum CRP concentrations were within the reference interval (22.9 ± 42.9 nmol/L) in 95% (18/19) of dogs. Logarithmic concentrations of serum CRP and plasma IL-6 were significantly correlated (P < 0.001, r = 0.479). None of the measured cytokines were associated with disease category or outcome. Conclusions -Serum CRP concentration is increased in dogs with SIRS, and decreases during treatment and hospitalization. Serum CRP, plasma IL-6, and plasma TNF-␣ concentrations cannot predict outcome in dogs with SIRS.

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“…Moreover, during the first postoperative week, C group of patients showed a greater exposure to TNF- α and IL-8 with respect to the other 2 groups. TNF- α is known to be involved in systemic inflammatory response syndrome (SIRS), which usually precedes MOFS in several ill patients [ 14 , 15 ], while IL-8 is a specific monocyte attracting chemokines that modulates monocyte activation, an important condition in organ damage and haemostatic complications [ 16 ]. These data suggest that, immediately after MCS intervention, the extent of inflammatory response related mainly to TNF- α and IL-8 signals could influence the development and degree of MOFS severity, contributing to subsequent clinical evolution of ESHF patients.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Early Inflammatory Response and Clinical Evolution of the Severe Multiorgan Failure in Mechanical Circulatory Support-Treated Patients

Caruso

Campolo

Verde

et al. 2014

Mediators of Inflammation

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Background. The mechanical circulatory support (MCS) is an effective treatment in critically ill patients with end-stage heart failure (ESHF) that, however, may cause a severe multiorgan failure syndrome (MOFS) in these subjects. The impact of altered inflammatory response, associated to MOFS, on clinical evolution of MCS postimplantation patients has not been yet clarified. Methods. Circulating cytokines, adhesion molecules, and a marker of monocyte activation (neopterin) were determined in 53 MCS-treated patients, at preimplant and until 2 weeks. MOFS was evaluated by total sequential organ failure assessment score (tSOFA). Results. During MCS treatment, 32 patients experienced moderate MOFS (tSOFA < 11; A group), while 21 patients experienced severe MOFS (tSOFA ≥ 11) with favorable (B group) or adverse (n = 13, C group) outcomes. At preimplant, higher values of left ventricular ejection fraction (LVEF) and estimated glomerular filtration rate (eGFR) were the only parameter independently associated with A group. In C group, during the first postoperative week, high levels of interleukin-8 (IL-8) and tumor necrosis factor (TNF)-α, and an increase of neopterin and adhesion molecules, precede tSOFA worsening and exitus. Conclusions. The MCS patients of C group show an excessive release to IL-8 and TNF-α, and monocyte-endothelial activation after surgery, that might contribute to the unfavourable evolution of severe MOFS.

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The Predictive Prognostic Values of Serum TNF-αin Comparison to SOFA Score Monitoring in Critically Ill Patients

Cited by 17 publications

References 14 publications

Histidine-rich glycoprotein as a prognostic biomarker for sepsis

Histidine-rich glycoprotein as a prognostic biomarker for sepsis

Inflammatory cytokine and C‐reactive protein concentrations in dogs with systemic inflammatory response syndrome

Relationship between Early Inflammatory Response and Clinical Evolution of the Severe Multiorgan Failure in Mechanical Circulatory Support-Treated Patients

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