The predictive value of high-magnification sperm morphology examination on ICSI outcomes in the presence of oocyte dysmorphisms

Abstract

Purpose To evaluate the relationship between oocyte dysmorphisms and IMSI outcomes Methods Data of IMSI cycles performed in 332 patients were included in this study. Patients were included only if presented more than four and less than 30 oocytes upon oocyte retrieval. Patients who underwent IMSI were matched, concerning female age and sperm parameters, with patients who underwent ICSI in the same period (n0332). The two groups (ICSI and IMSI) were compared with regard to treatment outcomes. The influence of IMSI on fertilization and embryo quality on D3 and D5, when oocyte dysmorphisms were present was analyzed. Results A total of 6444 oocytes were morphologically evaluated and injected. Regardless of the oocyte quality, IMSI performance was a determinant of the increased odds of development to high quality embryo on D3 (OR: 1.98; CI: 1.54-2.56) and D5 (OR: 3.27; CI: 1.61-6.66). Conclusions The selection of a morphologically normal spermatozoon under high-magnification is associated with increased embryo quality, regardless of the oocyte morphology. The injection of a spermatozoon, selected under highmagnification, into a morphologically normal oocyte leads to the highest probability of developing high quality embryos.

There is No Effect of Total Sperm Count on Pregnancy Rates in ICSI Cycles

“…In this study, fertilization rates, D3 and D5 embryo quality was found to be much better in Intracytoplasmic morphologically selected sperm injection (IMSI) than Intracytoplasmic sperm injection (ICSI). In this study, it is also said that good results were achieved when oocyte morphology was also included in evaluation [17,18]. There are similar studies as our's and also at the present time sperm DNA fragmentation is performed in many centers but still the choice for treatment is determined by a simple sperm parameters analysis in many technologically insufficient centers.…”

Intracytoplasmic morphologically selected sperm injection (IMSI) does not improve outcome in patients with two successive IVF-ICSI failures

“…We found no difference in embryo morphology. Except for two studies [23,28], IMSI does not improve the morphology of early embryos [14,19,21,22,29]. However, an increase of development at the blastocyst stage using IMSI has been demonstrated by some authors [28,30,31], although randomization at the oocyte level did not confirm this finding [22].…”