The predictive value of lncRNA MIR31HG expression on clinical outcomes in patients with solid malignant tumors

Abstract

Background Emerging studies have explored the prognostic value of MIR31HG in cancers, but its role remains elusive. Herein, we aimed to summarize the prognostic potential of MIR31HG in this study. Methods Several databases were searched for literature retrieval on Dec 5, 2019. Overall and subgroup analyses were conducted to measure the relationship between MIR31HG expression and clinical outcomes. Moreover, GEPIA was applied for validation of prognostic value of MIR31HG in tumor patients in TCGA dataset. Results Overall, seventeen studies with 2,573 patients were enrolled. Compared to counterparts, those patients with high MIR31HG expression tended to have shorter RFS. Notably, MIR31HG overexpression predicted unfavorable OS in lung cancer. By contrast, gastrointestinal cancer patients with elevated MIR31HG expression predicted better OS and disease-free survival. Additionally, MIR31HG overexpression was significantly associated with worse clinicopathological features including advanced tumor stage and LNM in lung cancer, but favorable clinical characteristics in gastrointestinal cancer. Moreover, the positive association between MIR31HG and OS in lung cancer was further confirmed in TCGA dataset. Conclusion Overexpression of MIR31HG suggested remarkable association with poor prognosis in terms of OS, tumor stage, and LNM in lung cancer, but favorable prognosis in gastrointestinal cancer. Therefore, MIR31HG may serve as a promising prognostic biomarker in multiple cancers.

The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression

“…Cancer is one of the life‐threatening diseases and remains a critical public health issue worldwide 1‐3 . Despite the tremendous improvements in cancer therapy in recent decades, there are still many patients who suffer from unsatisfactory outcomes 4 .…”

“…Compelling experimental evidences indicate an engagement of lncRNAs in pleiotropic pathophysiological functions related to tumorigenesis, like the cell growth, invasion, metastasis, apoptosis and chemo‐resistance, 16 by interaction with other macromolecules 17 . Accumulating studies have shown that lncRNAs could be considered as a promising candidate in cancer prognosis and diagnosis 1,4,7,18 . Accordingly, lncRNAs have attracted great attention due to their multifaceted modulatory functions and the capacity as predictive biomarkers in cancers 1,4,7 …”

“…Accumulating studies have shown that lncRNAs could be considered as a promising candidate in cancer prognosis and diagnosis 1,4,7,18 . Accordingly, lncRNAs have attracted great attention due to their multifaceted modulatory functions and the capacity as predictive biomarkers in cancers 1,4,7 …”

Upregulated Expression of LncRNA Nicotinamide Nucleotide Transhydrogenase Antisense RNA 1 is Correlated with Unfavorable Clinical Outcomes in Cancers

“…Long non-coding RNAs (lncRNAs) belong to non-coding RNAs whose lengths are longer than 200bp [7]. They have little or no capability of coding protein [8].…”

“…Recent studies have demonstrated that lncRNAs could drive pathophysiologic phenotypes through interaction with other cellular macromolecules including DNA, RNA and proteins [9]. Aberrant expression or functional abnormalities of LncRNAs have been linked with numerous human diseases, such as aging [10], degenerative disease [11], and cancer [12,7,13,14]. Recently, a pivotal role of lncRNA in tumor biological characteristics including proliferation, cell cycle arrest, invasion, migration [15], autophagy [16], and drug resistance [17] has also been revealed.…”