The Predictive Value of the Sentinel Lymph Node in Malignant Melanomas

Bachter, D.; Michl, Christiane; Büchels, H.; Vogt, Harry; Balda, Bernd‐Rüdiger

doi:10.1007/978-3-642-59537-0_13

Cited by 33 publications

(12 citation statements)

References 19 publications

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“…This fact reinforces the advantage of the SLNB for melanoma and other solid cancers as opposed to ELND. 10,12,27,[32][33][34][35][36][37] Regarding SLN status, 20.8% of the patients who underwent SLNB were found to have evidence of microscopic disease, a finding also consistent with other studies. 10,12,13,35,37,38 Interestingly, the higher rate of SLN positivity was found among the unusual locations or properly aberrant SLNs (34.6% vs 20.9%).…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Single-Institution Experience in the Management of Patients with Clinical Stage I and II Cutaneous Melanoma: Results of Sentinel Lymph Node Biopsy in 240 Cases

Rex

Paradelo

Mangas

et al. 2005

Dermatologic Surgery

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Section: Discussionsupporting

confidence: 89%

“…Those unexpected draining patterns underline the need for lymphatic mapping prior to any nodal surgery. This fact reinforces the advantage of the SLNB for melanoma and other solid cancers as opposed to ELND 10,12,27,32–37 …”

Section: Discussionsupporting

confidence: 61%

Single-Institution Experience in the Management of Patients with Clinical Stage I and II Cutaneous Melanoma: Results of Sentinel Lymph Node Biopsy in 240 Cases

Rex

Paradelo

Mangas

et al. 2005

Dermatologic Surgery

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“…As the thickness increases, the risk of positive sentinel lymph nodes increases from less than 5 percent for lesions less than 1.0 mm to 30 to 50 percent for lesions greater than 4.0 mm. 10,15,18 Other factors that may also be associated with a positive sentinel lymph node include ulceration, mitotic rate, younger age, microsatellitosis, angiolymphatic invasion, Clark level, and location. 15,18 -21 Ongoing studies will help determine to what degree these other factors correlate with a positive sentinel lymph node biopsy, independent of Breslow depth.…”

Section: Discussionmentioning

confidence: 98%

The Utility of Sentinel Lymph Node Biopsy in Head and Neck Melanoma in the Pediatric Population

Pacella

Lowe

Bradford

et al. 2003

Plastic and Reconstructive Surgery

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Intraoperative lymph node mapping and sentinel lymph node biopsy have proven beneficial techniques in staging adult patients with melanoma of the head and neck, where there is great variability in lymphatic drainage. This technique has also been applied to pediatric patients with truncal cutaneous melanomas in an effort to determine nodal status without the morbidity associated with complete lymph node dissection. Nevertheless, the utility of sentinel lymph node biopsy in head and neck melanoma in the pediatric population has not been established. The objective of the authors' study was to determine the clinical utility of intraoperative lymph node mapping and sentinel lymph node biopsy of head and neck melanoma in the pediatric population. The authors reviewed the records of seven pediatric patients with head and neck melanoma or borderline melanocytic proliferations of unknown biologic potential who underwent intraoperative lymph node mapping and sentinel lymph node biopsy between 1998 and 2001. All sentinel lymph node specimens were examined by a melanoma dermatopathologist for the presence of metastatic melanoma. The mean operative time for each case was 3 hours, 8 minutes (range, 2 hours, 15 minutes to 3 hours, 50 minutes). All seven pediatric patients who underwent extirpation of a primary head and neck melanoma and preoperative lymphoscintigraphy had unique and identifiable basins of drainage to regional nodal groups. Four of seven patients had at least one positive sentinel lymph node. Overall, five of 19 sentinel nodes (26 percent) resected had evidence of metastatic melanoma. Of the patients with positive sentinel lymph nodes, two of the primary lesions were diagnosed as melanoma while two were initially considered atypical melanocytic proliferations of uncertain biologic potential with melanoma in the differential diagnosis. Sentinel lymph nodes in pediatric patients with melanoma of the head and neck can be successfully mapped and biopsied, as in adult patients. In addition, this procedure can provide critical diagnostic information for those pediatric patients with diagnostically challenging, controversial, or borderline melanocytic lesions.

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“…The sentinel lymph node (SLN), defined as the first tumour‐draining lymph node, is a sensitive tool to diagnose lymph node status 1 . Removal of this lymph node, called sentinel lymphonodectomy (SLNE), has been established in the management of patients with malignant melanoma and breast cancer 1–7 . Its prognostic value was shown for melanoma and has also been investigated in internal malignancies such as gastrointestinal and colorectal cancer, prostate cancer, nonsmall cell lung cancer, vulval cancer, nodular thyroid neoplasms and cancer of the mucous membranes in the head and neck region 8–14 …”

mentioning

confidence: 99%