The predictor factor of final visual acuity (VA) of acute retrobulbar neuritis patients receiving optic neuritis treatment trial (ONTT) regiment

Abstract

The study aimed to investigate the efficacy of intravenous optic neuritis treatment trial (ONTT) regiment on the treatment of patients with acute retrobulbar neuritis. This was a cross sectional study using medical records data of patients diagnosed with unilateral or bilateral retrobulbar neuritis by normal funduscopic findings and typical optic neuritis perimetry results within 14 days of onset from the Neuro-ophthalmology Clinic, Department of Ophthalmology, Dr. Sardjito General Hospital, Yogyakarta from January to December 2015. Medical records data of patients who received 1000 mg methylprednisolone IV per day for 3 days followed by 11 days 1 mg/kg body weight oral prednisolone were reviewed. Visual acuity (VA) at onset, final VA at time of follow up, delta VA improvement and time of follow up were included in the analyses. Twenty data of patients aged 33.95±8.07 years with VA at onset of 1.96±0.81 (~ 1 m CF) were analyzed in this study. Significantly improvement in final VA after treatment to be 1.39±1.12 (~ 5 m CF) was reported (p=0.001). The VA at onset was a predictive factor for final VA (p <0.001). Every 1.17 increase of final VA for every one-point decreased VA at onset (p<0.001). Time follow up showed to be trend (p=0.059), however, age and sex were not a predictive factor of final VA (p>0.05). In conclusion, there is VA improvement after the treatment of ONTT regiment. The VA at onset is a predictive factor of final VA on patients with acute retrobulbar neuritis.