The preparation, characterization, and stability evaluation of a microemulsion-based oral spray containing clove oil for the treatment of oral candidiasis

Monton, Chaowalit; Settharaksa, Sukanya; Suksaeree, Jirapornchai; Chusut, Tun

doi:10.1016/j.jddst.2020.101735

Cited by 15 publications

(12 citation statements)

References 24 publications

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“…PEG 400 6.5–10% was selected in formulations designed for intranasal delivery to increase the rate of survival in glioblastoma treatment [ 77 ], while concentrations of 15–21% were selected for designing microemulsions for the oral delivery of carvedilol as suitable solubilizer that acts synergistically with peppermint oil 10% and Tween 80 15–21% [ 78 ]. Amounts of 6–9% PEG 400 were tested for antifungal buccal sprays, emphasizing the importance of the stabilizers for microemulsion development [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…It is unanimously accepted that the droplet size is not part of a single narrowed domain but may detect some extended droplet sizes that can be evaluated from the peak distribution, as was reported. In the study of Monton C. et al, the incorporation of clove oil 2% into microemulsions stabilized with Tween 80 9–18% and PEG 400 6–9% was quantified by sized distributions in a maximum range of D 10%, D 50%, D 90% of 20.7–686.6 nm, with Span values between 1.3 ± 0.0 and 16.3 ± 1.3 [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, novel nanotherapeutic systems proposed progress in increasing API bioavailability and therapeutic efficacy [ 25 ]. Vesicular systems [ 26 ], nanoparticles [ 27 ], and micro-/nanoemulsified systems [ 28 , 29 , 30 ] are remarked as the main advances meant to improve the solubility and retention of the antifungals in oral mucosa [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Microemulsions are versatile nanocolloidal carriers able to sustain drug solubilization and release at the level of buccal mucosa, as it was reported for several natural and synthetic antifungal agents like clove oil in the form of spray-able liquid formulations [ 28 ], clotrimazole [ 43 ], and itraconazole [ 30 ], designed as mucoadhesive structures.…”

Section: Introductionmentioning

confidence: 99%

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Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

Pharmaceutics

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This research aimed to develop miconazole-based microemulsions using oleic acid as a natural lipophilic phase and a stabilizer mixture comprising Tween 20 and PEG 400 to solubilize miconazole as an antifungal agent known for its activity in oral candidiasis and to improve its bioavailability. The formulation and preparation process was combined with a mathematical approach using a 23-full factorial plan. Fluid and gel-like microemulsions were obtained and analyzed considering pH, conductivity, and refractive index, followed by extensive analyses focused on droplet size, zeta potential, rheological behavior, and goniometry. In vitro release tests were performed to assess their biopharmaceutical characteristics. Independent variables coded X1-Oleic acid (%, w/w), X2-Tween 20 (%, w/w), and X3-PEG 400 (%, w/w) were analyzed in relationship with three main outputs like mean droplet size, work of adhesion, and diffusion coefficient by combining statistical tools with response surface methodology. The microemulsion containing miconazole base–2%, oleic acid–5%, Tween 20–40%, PEG 400–20%, and water–33% exhibited a mean droplet size of 119.6 nm, a work of adhesion of 71.98 mN/m, a diffusion coefficient of 2.11·10−5 cm2/s, and together with remarked attributes of two gel-like systems formulated with higher oil concentrations, modeled the final optimization step of microemulsions as potential systems for buccal delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

Pharmaceutics

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“…Rich in eugenol, clove oil was considered a natural alternative to antibiotherapy to avoid drug resistance and promote high antimycotic activity. Complementarily, PEG 400 was considered essential to assure an increased release of eugenol from microemulsion-based spray [ 136 ]. Eugenol, as a monoterpene phenol, is recognized for its antifungal activity related to the binding and inhibition of ergosterol biosynthesis.…”

Section: Biomaterials and Nanotechnological Approachesmentioning

confidence: 99%

Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis

Anuța

Talianu

Dinu-Pîrvu

et al. 2022

IJMS

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Oral candidiasis has a high rate of development, especially in immunocompromised patients. Immunosuppressive and cytotoxic therapies in hospitalized HIV and cancer patients are known to induce the poor management of adverse reactions, where local and systemic candidiasis become highly resistant to conventional antifungal therapy. The development of oral candidiasis is triggered by several mechanisms that determine oral epithelium imbalances, resulting in poor local defense and a delayed immune system response. As a result, pathogenic fungi colonies disseminate and form resistant biofilms, promoting serious challenges in initiating a proper therapeutic protocol. Hence, this study of the literature aimed to discuss possibilities and new trends through antifungal therapy for buccal drug administration. A large number of studies explored the antifungal activity of new agents or synergic components that may enhance the effect of classic drugs. It was of significant interest to find connections between smart biomaterials and their activity, to find molecular responses and mechanisms that can conquer the multidrug resistance of fungi strains, and to transpose them into a molecular map. Overall, attention is focused on the nanocolloids domain, nanoparticles, nanocomposite synthesis, and the design of polymeric platforms to satisfy sustained antifungal activity and high biocompatibility with the oral mucosa.

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Optimization of Eugenol Extraction From Piper betle Leaves Using Natural Deep Eutectic Solvents and Ultrasound‐Assisted Extraction

Monton,

Wunnakup,

Sueree

et al. 2024

Separation Science Plus

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Piper betle L. (Piperaceae) is a herbal plant used in Thai traditional medicine for its antifungal and antiallergic properties, particularly through topical application. This study aimed to optimize the extraction of Piper betle leaves using natural deep eutectic solvents to enhance the extraction efficiency of eugenol, the active compound in Piper betle leaves. Various types of hydrogen bond donors—including glycolic acid, lactic acid, malic acid, tartaric acid, ascorbic acid, and citric acid—were combined with a hydrogen bond acceptor, choline chloride, to prepare natural deep eutectic solvents. The results indicated that lactic acid was the most effective hydrogen bond donor for eugenol extraction. Subsequently, the choline chloride:lactic acid molar ratios, the natural deep eutectic solvent:water mass ratios, and ultrasonication times were varied. Results showed that the optimal conditions based on one‐factor‐at‐a‐time approach were a choline chloride:lactic acid molar ratio of 1:5, a natural deep eutectic solvent:water mass ratio of 2:1, and an ultrasonication time of 30 min. Under these conditions, the eugenol concentration reached 457.22 ± 21.68 µg/mL, compared to 224.76 ± 6.99 µg/mL when ethanol was used. In conclusion, this study successfully optimized the extraction of eugenol from Piper betle leaves using natural deep eutectic solvents. These findings suggest that natural deep eutectic solvents could be a more effective solvent for the extraction of eugenol.

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The preparation, characterization, and stability evaluation of a microemulsion-based oral spray containing clove oil for the treatment of oral candidiasis

Cited by 15 publications

References 24 publications

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis

Optimization of Eugenol Extraction From Piper betle Leaves Using Natural Deep Eutectic Solvents and Ultrasound‐Assisted Extraction

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