The Preparation of Some 2- and 3-Derivatives of 1,8-Naphthyridine from 2-Amino-6-hydroxypyridine

Roszkiewicz, Witold; Woźniak, M.

doi:10.1055/s-1976-24162

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1977

2005

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Cited by 20 publications

(2 citation statements)

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“…The cyclic amides 4-10 were prepared according to the literature data: quinolin-2(1H)-one (4) [29], isoquinolin-1(2H)-one (5) [30], quinazolin-4(3H)-one (6) [31], quinoxalin-2(1H)-one (7) [32], phthalazin-1(2H)-one (8) [33], 1,8-naphthyridin-2(1H)-one (9) [34], and pyrido[2,3-b]pyrazin-6(5H)-one (10) [35].…”

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confidence: 99%

Synthesis and Prediction of Bioactivity of New Nitroimidazole Derivatives.

2005

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Section: Resultsmentioning

confidence: 99%

Synthesis and Prediction of Bioactivity of New Nitroimidazole Derivatives.

2005

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Section: Methodsmentioning

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Synthesis and prediction of bioactivity of new nitroimidazole derivatives

Kowalski

Nowak

Szpakiewicz

2005

Journal of Heterocyclic Chem

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Syntheses of 1-propyl derivatives of 2-methyl-5-nitroimidazole (11-17), containing various azanaphthalene systems attached at 3-position of the propyl group have been described. Due to structural similarity of the derivatives 11-17 with metronidazole, an antibacterial and antiprotozoal drug, pharmacological properties of the target compounds were predicted using the PASS program. Polar surface area (PSA) parameter was also applied for estimation of the physical properties of 11-17 as drug-like candidates.

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