2022
DOI: 10.15421/022303
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The prerequisites for the development of type 2 diabetes or prediabetes in rats fed a high-fat diet

Abstract: It is known that the pathogenesis of type 2 diabetes in humans is based on two main factors – insulin resistance and inappropriate secretory activity of β-cells of the pancreas. In animals, the role of these mechanisms has not been clearly characterized, and the differences in the manifestations of experimental diabetes under the same conditions are not sufficiently substantiated. In order to study the prerequisites and mechanisms of the development of experimental type 2 diabetes or prediabetes under lipid ov… Show more

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“…Western blot analysis. Protein expression was assayed in frozen brain hemisphere samples by immunoblotting as previously described (Portnychenko et al, 2023). Briefly, tissue lysates (100 µg of protein) were subjected to SDS-PAGE and transferred onto PVDF membrane (Sigma).…”
Section: Dna-comet Assay (Alkaline)mentioning
confidence: 99%
“…Western blot analysis. Protein expression was assayed in frozen brain hemisphere samples by immunoblotting as previously described (Portnychenko et al, 2023). Briefly, tissue lysates (100 µg of protein) were subjected to SDS-PAGE and transferred onto PVDF membrane (Sigma).…”
Section: Dna-comet Assay (Alkaline)mentioning
confidence: 99%