The prevalence and genotype distribution of human papilloma virus in cervical squamous intraepithelial lesion and squamous cell carcinoma in Taizhou, China

Jin, Rongrong; Yang, Xumei; Bao, Jingjing; Zhang, Wenyan; Dou, Rongrong; Yuan, Donglan; Yang, Qing; Jiang, Lin; Yu, Hong

doi:10.1097/md.0000000000026593

Cited by 6 publications

(6 citation statements)

References 32 publications

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“…Age is one of the most important factors in uencing HPV infection, and in the present study, HPV infection in high-grade squamous intraepithelial lesions (CIN II and III) was noted in patients aged 40-49 years. This nding was similar to that in studies from Taizhou and Jiangsu provinces [14,32]. The age group with the highest prevalence of HPV in the ICC group was the ≥ 60 years group(incidence: 46.17%); this incidence was higher than that in the 50-59 years age group in a study from Taizhou [14], higher than that in the 40-44 years age group in a study from Shanghai and Zhejiang [33], and higher than that in the 41-50 years age group in a study from Jiangsu [32].…”

Section: Discussionsupporting

confidence: 91%

“…In the present study, HPV 52, 16, and 58 were found to be the major contributors to CIN I and II, and HPV 16, 58, and 52 were the major contributors to CIN III and ICC, Similar to Shanxi Province [20], Distinguish from Jiangsu and Sichuan [14,23]. On the whole, these ndings are similar to those of previous domestic and international studies.…”

Section: Discussionsupporting

confidence: 90%

“…In this study, the prevalence of HPV in cervical lesions was used as the main research indicator, which is known to be 83.83% based on the results of similar published literature [14]. Using the following formula, α = 0.05 (two-sided test) was selected, the permissible error δ=±1.3%, 𝑍1-𝛼/2 = 1.96, p = 83.83%, 𝑛=(𝑍1-𝛼/2𝛿) 2 𝑝(1-𝑝), 3082 cases need to be investigated.…”

Section: Statisticsmentioning

confidence: 99%

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Human papillomavirus infections among women with cervical lesions and cervical cancer in Yueyang, China: A cross-sectional study of 3674 women from 2019 to 2022

Zeng,

Zhang,

et al. 2023

Preprint

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PURPOSE To investigate the distribution of the incidence and genotypes of human papillomavirus (HPV) among women with cervical cancer (CC) and precancerous cervical lesions in Yueyang City, China, to develop prevention and control strategies for CC. METHODS 3674 patients with cervical lesions diagnosed by pathology as a gold standard at 7 hospitals in Yueyang City between September 2019 and September 2022 were selected. They included 1910, 718, 576, and 470 cases of cervical intraepithelial neoplasia (CIN) I, CIN II, CIN III, and CC, respectively. A cross-sectional study combining HPV test results from these cases. RESULTS The total HPV prevalence was 74.69% (95%CI: 73.28–76.09%) in 3674 patients. The incidence of high- and low-risk HPV was 73.46% and 7.21%, respectively. The prevalence of HPV in CIN I, CIN II, CIN III, and invasive CC (ICC) groups was 66.65% (1273/1910, 95%CI: 64.53–68.77%), 80.78% (580/718, 95%CI: 77.89–83.67%), 83.88% (483/576, 95%CI: 80.84–86.87%), and 86.81% (408/470, 95%CI: 83.74–89.88%), respectively. The top three HPV subtypes in ICC are HPV16, HPV52, and HPV58. The prevalence of HPV 16 increased with increasing disease severity, with this genotype being present in 12.57%, 20.89%, 36.98%, and 50.85% of CIN I, CIN II, CIN III, and ICC cases, respectively (p < 0.001). Single HPV infection was predominant in cervical lesions, with a prevalence of 48.50% (95%CI: 46.89–50.12%). The HPV prevalence varied by age, being highest among women with ICC, CIN I, CIN II and CIN III aged ≥ 60 years, 50 to 59 years, 40 to 49 years, and 40 to 49 years, respectively. CONCLUSION The prevalence of HPV in patients with cervical lesions in Yueyang City was very high, with HPV 16, 52, 58, 53, and 51 being the five most common HPV genotypes in patients with cervical lesions. These results serve as data for supporting future vaccination and screening programs.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Statisticsmentioning

confidence: 99%

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Human papillomavirus infections among women with cervical lesions and cervical cancer in Yueyang, China: A cross-sectional study of 3674 women from 2019 to 2022

Zeng,

Zhang,

et al. 2023

Preprint

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“…[4][5][6] Prevalence of HPV infection and type-specific distribution vary greatly between nations 7 and between grades of cervical cytology. [8][9][10][11][12][13] Data on the prevalence and distribution of HPV types by cervical cytology grade from regions in Europe characterized by high cervical cancer incidence and mortality are scarce. 6,7,14 Various types of medical data (electronic health records, billing data, registries) are generated at a high speed and the growth in research involving data mining (DM) and artificial intelligence (AI) in health care has been exponential.…”

Section: Introductionmentioning

confidence: 99%

“…Previous reports have documented significant regional differences in hrHPV prevalence worldwide (including in women with normal cytology and invasive cancer) . Prevalence of HPV infection and type-specific distribution vary greatly between nations and between grades of cervical cytology . Data on the prevalence and distribution of HPV types by cervical cytology grade from regions in Europe characterized by high cervical cancer incidence and mortality are scarce …”

Section: Introductionmentioning

confidence: 99%

Prevaccination Prevalence of Type-Specific Human Papillomavirus Infection by Grade of Cervical Cytology in Estonia

et al. 2023

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ImportanceLarge-scale data on type-specific human papillomavirus (HPV) prevalence and disease burden worldwide are needed to guide cervical cancer prevention efforts. Promoting the research and application of health care big data has become a key factor in modern medical research.ObjectiveTo examine the prevaccination prevalence of high-risk HPV (hrHPV) and type distribution by cervical cytology grade in Estonia.Design, Setting, and ParticipantsThis cross-sectional study used text mining and the linking of data from electronic health records and health care claims to examine type-specific hrHPV positivity in Estonia from 2012 to 2019. Participants were women aged at least 18 years. Statistical analysis was performed from September 2021 to August 2022.Main Outcomes and MeasuresType-specific hrHPV positivity rate by cervical cytological grade.ResultsA total of 11 017 cases of cervical cytology complemented with data on hrHPV testing results between 2012 and 2019 from 66 451 women aged at least 18 years (mean [SD] age, 48.1 [21.0] years) were included. The most common hrHPV types were HPV16, 18, 31, 33, 51 and 52, which accounted for 73.8% of all hrHPV types detected. There was a marked decline in the positivity rate of hrHPV infection with increasing age, but the proportion did not vary significantly based on HPV type. Implementation of nonavalent prophylactic vaccination was estimated to reduce the number of women with high-grade cytology by 50.5% (95% CI, 47.4%-53.6%) and the number with low-grade cytology by 27.8% (95% CI, 26.3%-29.3%), giving an overall estimated reduction of 33.1% (95% CI, 31.7%-34.5%) in the number of women with precancerous cervical cytology findings.Conclusions and RelevanceIn this cross-sectional study, text mining and natural language processing techniques allowed the detection of precursors to cervical cancer based on data stored by the nationwide health system. These findings contribute to the literature on type-specific HPV distribution by cervical cytology grade and document that α-9 phylogenetic group HPV types 16, 31, 33, 52 and α-7 phylogenetic group HPV 18 are the most frequently detected in normal-to-high-grade precancerous lesions in Estonia.

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Distribution of high-risk human papillomavirus in women with ASC-US or LSIL in Tunisian women: Place of HPV testing for women triage in Tunisia

Ardhaoui

Rhouma²,

Guettiti³

et al. 2023

Diagnostic Microbiology and Infectious Disease

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The prevalence and genotype distribution of human papilloma virus in cervical squamous intraepithelial lesion and squamous cell carcinoma in Taizhou, China

Cited by 6 publications

References 32 publications

Human papillomavirus infections among women with cervical lesions and cervical cancer in Yueyang, China: A cross-sectional study of 3674 women from 2019 to 2022

Human papillomavirus infections among women with cervical lesions and cervical cancer in Yueyang, China: A cross-sectional study of 3674 women from 2019 to 2022

Prevaccination Prevalence of Type-Specific Human Papillomavirus Infection by Grade of Cervical Cytology in Estonia

Distribution of high-risk human papillomavirus in women with ASC-US or LSIL in Tunisian women: Place of HPV testing for women triage in Tunisia

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