The prevalence of CFTR mutations in patients with chronic rhinosinusitis: A systematic review and meta‐analysis

Yong, Michael; Hernaiz-Leonardo, Juan Carlos; Alqunaee, Marwan; Quon, Bradley S.; Javer, Amin R.

doi:10.1111/coa.13875

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…TBXA2R is known to stimulate vascular endothelial cell pro-inflammatory responses [51]. CFTR, as a chloride channel, controls ion and water secretion and absorption in epithelial tissues, thereby affecting mucus production [52].…”

Section: Discussionmentioning

confidence: 99%

Deciphering the Systemic Impact of Herbal Medicines on Allergic Rhinitis: A Network Pharmacological Approach

Park,

Lee,

Kim

et al. 2024

Life

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Allergic rhinitis (AR) is a systemic allergic disease that has a considerable impact on patients’ quality of life. Current treatments include antihistamines and nasal steroids; however, their long-term use often causes undesirable side effects. In this context, traditional Asian medicine (TAM), with its multi-compound, multi-target herbal medicines (medicinal plants), offers a promising alternative. However, the complexity of these multi-compound traits poses challenges in understanding the overall mechanisms and efficacy of herbal medicines. Here, we demonstrate the efficacy and underlying mechanisms of these multi-compound herbal medicines specifically used for AR at a systemic level. We utilized a modified term frequency–inverse document frequency method to select AR-specific herbs and constructed an herb–compound–target network using reliable databases and computational methods, such as the Quantitative Estimate of Drug-likeness for compound filtering, STITCH database for compound-target interaction prediction (with a high confidence score threshold of 0.7), and DisGeNET and CTD databases for disease-gene association analysis. Through this network, we conducted AR-related targets and pathway analyses, as well as clustering analysis based on target-level information of the herbs. Gene ontology enrichment analysis was conducted using a protein–protein interaction network. Our research identified 14 AR-specific herbs and analyzed whether AR-specific herbs are highly related to previously known AR-related genes and pathways. AR-specific herbs were found to target several genes related to inflammation and AR pathogenesis, such as PTGS2, HRH1, and TBXA2R. Pathway analysis revealed that AR-specific herbs were associated with multiple AR-related pathways, including cytokine signaling, immune response, and allergic inflammation. Additionally, clustering analysis based on target similarity identified three distinct subgroups of AR-specific herbs, corroborated by a protein–protein interaction network. Group 1 herbs were associated with the regulation of inflammatory responses to antigenic stimuli, while Group 2 herbs were related to the detection of chemical stimuli involved in the sensory perception of bitter taste. Group 3 herbs were distinctly associated with antigen processing and presentation and NIK/NF-kappa B signaling. This study decodes the principles of TAM herbal configurations for AR using a network pharmacological approach, providing a holistic understanding of drug effects beyond specific pathways.

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Section: Discussionmentioning

confidence: 99%

Deciphering the Systemic Impact of Herbal Medicines on Allergic Rhinitis: A Network Pharmacological Approach

Park,

Lee,

Kim

et al. 2024

Life

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“…Pinto et al found that the region of chromosome 7q31.1–7q32.1 that is associated with the CFTR gene may have a role in the development of CRS [ 72 ]. Young et al, based on reports from the USA and Europe, indicated that the prevalence of CFTR mutations in patients with CRS was 5.65% and that the prevalence of the Phe508 mutation was 4.22% [ 73 ]. According to recently reported data, CFTR polymorphism (e.g., M470V) [ 70 ] and G551D- CFTR mutation can predispose persons to CRS [ 74 ], especially CRSwNP.…”

Section: From Classical Microbiology To Molecular and Omics Methodsmentioning

confidence: 99%

Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis

Michalik,

Krawczyk

2024

IJMS

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Chronic rhinosinusitis (CRS) is a significant public health problem. Bacterial colonization and impaired mucociliary clearance play a significant role in the inflammatory process. Several inflammatory pathways and host defense elements are altered in CRS, which may contribute to observed differences in the microbiome. To date, researching CRS has been difficult due to limited access to the studied tissue and a lack of available biomarkers. Ongoing scientific research is increasingly based on simple and objective analytical methods, including sensors, detection with PCR, and sequencing. Future research on microbiota and human factors should also include genomics, transcriptomics, and metabolomics approaches. This report analyzes the changes that occur in the paranasal sinuses of people with acute and chronic rhinosinusitis, the composition of the microbiota, the human genetic markers that may shed light on the predisposition to CRS, and the advantages and disadvantages of classical and molecular diagnostic methods, as well as addressing the difficulties of sinusitis treatment.

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Genetics and epigenetics of chronic rhinosinusitis

Lal¹,

Brar²,

Ramkumar³

et al. 2023

Journal of Allergy and Clinical Immunology

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The prevalence of CFTR mutations in patients with chronic rhinosinusitis: A systematic review and meta‐analysis

Cited by 4 publications

References 28 publications

Deciphering the Systemic Impact of Herbal Medicines on Allergic Rhinitis: A Network Pharmacological Approach

Deciphering the Systemic Impact of Herbal Medicines on Allergic Rhinitis: A Network Pharmacological Approach

Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis

Genetics and epigenetics of chronic rhinosinusitis

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