The Prevalence of Histopathological Features of Pneumonia in Goats with Symptomatic Caprine Arthritis-Encephalitis

Moroz, Agata; Czopowicz, Michał; Sobczak-Filipiak, M.; Dolka, I.; Rzewuska, Magdalena; Kizerwetter-Świda, Magdalena; Chrobak-Chmiel, Dorota; Mickiewicz, Marcin; Witkowski, Lucjan; Szaluś‐Jordanow, Olga; Nalbert, Tomasz; Potârniche, Adrian Valentin; Barszcz, Karolina; Markowska-Daniel, Iwona; Puchała, R.; Bagnicka, Emilia; Kaba, Jarosław

doi:10.3390/pathogens11060629

Cited by 8 publications

(5 citation statements)

References 56 publications

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“…19 In yet another study, more than half of the autopsied goats from a Polish SRLV type A-positive dairy goat herd had histological lesions of chronic interstitial pneumonia. 20 Contrary to our case, these goats exhibited no gross lesions, and the main clinical sign in the herd was arthritis.…”

Section:  Of contrasting

confidence: 99%

An outbreak of small ruminant lentivirus in a Swedish dairy goat herd

Persson

Salenstedt

Andersson

et al. 2023

Vet Record Case Reports

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Small ruminant lentivirus causes severe economic losses, and negatively affects animal welfare in goat herds across the world. The aim of this study was to describe the clinical and pathological consequences of the disease in an affected goat herd, as well as to sequence the virus in infected animals. Seventy‐six percent of the sampled animals were small ruminant lentivirus seropositive. The most prominent signs of disease were respiratory signs found in clinical examinations and chronic interstitial pneumonia found at postmortem examination. All animals with pneumonia also showed evidence of infection with Muellerius capillaris. The cell count in bulk milk was high and most likely related to the high small ruminant lentivirus seroprevalence within the herd. Small ruminant lentivirus was successfully detected in the lungs, bronchial lymph nodes and udder tissues using polymerase chain reaction. The phylogenetic analysis of the obtained sequences revealed the highest similarity with small ruminant lentiviruses in group C, which consists of viruses which have previously been found in Norwegian goats and sheep.

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Section:  Of contrasting

confidence: 99%

An outbreak of small ruminant lentivirus in a Swedish dairy goat herd

Persson

Salenstedt

Andersson

et al. 2023

Vet Record Case Reports

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“…According to several studies, there are complex relationships between various cell immunological components. These proteins, for instance, have been found to interact with one another and have an impact on the development of different immune globulins, complements, and acute phase reactive proteins, creating a complex network structure [ 84 , 85 ]. As a result, we anticipate that infectious pneumonia was the primary cause of the majority of the pneumonia cases in our study.…”

Section: Discussionmentioning

confidence: 99%

Individual Genomic Loci and mRNA Levels of Immune Biomarkers Associated with Pneumonia Susceptibility in Baladi Goats

Ateya

Al‐Sharif

Abdo

et al. 2023

Veterinary Sciences

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The effectiveness of breeding for inherent disease resistance in animals could be considerably increased by identifying the genes and mutations that cause diversity in disease resistance. One hundred and twenty adult female Baladi goats (sixty pneumonic and sixty apparently healthy) were used in this study. DNA and RNA were extracted from blood samples collected from the jugular vein of each goat. SLC11A1, CD-14, CCL2, TLR1, TLR7, TLR8, TLR9, β defensin, SP110, SPP1, BP1, A2M, ADORA3, CARD15, IRF3, and SCART1 SNPs that have been previously found to be associated with pneumonia resistance/susceptibility were identified via PCR-DNA sequencing. The pneumonic and healthy goats differed significantly, according to a Chi-square analysis of the discovered SNPs. The mRNA levels of the studied immune markers were noticeably greater in the pneumonic goats than in the healthy ones. The findings could support the significance of the use of immune gene expression profiles and nucleotide variations as biomarkers for the susceptibility/resistance to pneumonia and provide a practical management technique for Baladi goats. These results also suggest a potential strategy for lowering pneumonia in goats by employing genetic markers linked to an animal’s ability to fend off infection in selective breeding.

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“…The pathogenesis of SRLV infection in sheep, in which the lungs are the main target organ, naturally promotes the respiratory route of transmission in this species ( 38 , 39 ). Nevertheless, some studies indicate that subclinical interstitial pneumonia also develops in SRLV-infected goats ( 20 , 44 ). These observations give rise to the suspicion that the respiratory route may play a more important role than the lactogenic route in SRLV transmission in goats as it does in sheep.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal study on seroreactivity of goats exposed to colostrum and milk of small ruminant lentivirus–infected dams

Kaba¹,

Czopowicz²,

Witkowski³

et al. 2022

Journal of Veterinary Research

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Introduction Small ruminant lentivirus (SRLV) causes caprine arthritis-encephalitis in goats and maedi-visna disease in sheep. Transmission is via ingestion of colostrum and milk from infected dams or long-term direct contact between animals. Lifelong seroconversion can occur several weeks after infection via ingestion. However, sub-yearling lambs that ingest contaminated colostrum may be able to clear the infection and become seronegative. Whether a similar phenomenon occurs in goats remains unknown. Therefore, the serological status of goats was studied longitudinally from the moment of natural exposure to colostrum and milk of SRLV-positive dams through the age of 24 months. Material and Methods Between February 2014 and March 2017 a dairy goat herd was studied which had been infected with SRLV for more than 20 years and carried maedi-visna virus-like genotype A subtype A17. Thirty-one kids born to dams seropositive for SRLV for at least a year beforehand were followed. They ingested colostrum immediately after birth and then remained with their dams for three weeks. The goats were tested serologically every month using two commercial ELISAs. The clinical condition of the goats was also regularly assessed. Results Out of 31 goats, 13 (42%) seroconverted at the age ranging from 3 to 22 months with a median of 5 months. Two goats seroconverted in the second year of life. The other eleven did so before the age of one year; two of these reverted to seronegative status. Only 9 out of 31 goats (29%) seroconverted in the first year of life and remained seropositive. They were early and stable seroreactors to which SRLV was transmitted lactogenically. The age at which they seroconverted ranged from 3 to 10 months with a median of 5 months. In 8 of the 18 persistently seronegative goats, a single isolated positive result occurred. No goats showed any clinical signs of arthritis. The level of maternal antibodies at the age of one week did not differ significantly between the stable seroreactors and the remainder. Conclusion Seroconversion appears to occur in less than 50% of goats exposed to heterologous SRLV genotype A via ingestion of colostrum and milk from infected dams and is delayed by 3–10 months. The natural lactogenic route of transmission of SRLV genotype A in goats appears to be less effective than this route of genotype B transmission reported in earlier studies.

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The Prevalence of Histopathological Features of Pneumonia in Goats with Symptomatic Caprine Arthritis-Encephalitis

Cited by 8 publications

References 56 publications

An outbreak of small ruminant lentivirus in a Swedish dairy goat herd

An outbreak of small ruminant lentivirus in a Swedish dairy goat herd

Individual Genomic Loci and mRNA Levels of Immune Biomarkers Associated with Pneumonia Susceptibility in Baladi Goats

Longitudinal study on seroreactivity of goats exposed to colostrum and milk of small ruminant lentivirus–infected dams

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