The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis

Lopes, Luísa Bandeira; Machado, Vanessa; Mascarenhas, Paulo; Mendes, José João; Botelho, João

doi:10.1038/s41598-021-01541-7

Cited by 68 publications

(53 citation statements)

References 119 publications

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“…Most of the included studies reported no significant difference of prevalence between two genders [ 18 , 20 , 21 , 23 , 25 , 27 – 30 , 32 ] which in in accordance with the results reported by other systematic reviews [ 11 , 33 ]. However, two reported that MIH was more prevalent in girls [ 19 , 24 ] which can be attributed to the difference in time of eruption between two genders [ 34 ].…”

Section: Discussionsupporting

confidence: 88%

“…A previous systematic review in 2018, estimated a 14.2% global prevalence of MIH, with the highest and lowest prevalence in South America (18.0%) and Africa (10.9%) respectively [ 10 ]. A more recent meta-analysis published in 2021, reported a pooled prevalence of 13.5%, with the highest and lowest prevalence in American (15.3%) and Asian (10.7%) continents [ 11 ]. Other studies have even reported prevalence as low as 2.7% (Egypt) [ 12 ] to up to 19.7% (Brazil) [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Molar-incisor hypomineralization in Iranian children – A systematic review and narrative synthesis

et al. 2022

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Introduction Molar-incisor hypomineralization is a developmental defect of enamel with clinical features vary from demarcated opacities to severe tissue breakdown which calls for considerable preventive and interceptive measures. The aim of this article was to systematically review the literature on the prevalence of MIH in Iran and highlight the condition in Iranian children. Materials and Methods A systematic search of literature was conducted in Scopus, Pubmed, Ovid, Embase, Web of Science, and Google-Scholar as well as national Iranian database and digital archives of dental schools from the beginning of 2000 to the end of 2021 for published and unpublished studies. Data from cross-sectional, cohort, and case-control studies on prevalence of molar-incisor hypomineralization among 6–13-year-old children was gathered, using the following MeSH terms and keywords and their Persian equivalents: Prevalence, Hypomineralisation, Hypomineralization, MIH, “molar incisor”, “molar-incisor”, “cheese molars”, “Hypomineralised first permanent molars”, “Hypomineralized first permanent molars”, “developmental defects of enamel”, “enamel developmental defects”, Iran*. Methodological quality and the risk of bias of quantitative studies was assessed using a modified version of Newcastle-Ottawa Scale. Due to the considerable clinical and statistical heterogeneity of the included studies, pooling of data through meta-analysis was not possible. Therefore, a descriptive synthesis of data was performed. Results Fifteen cross-sectional studies with a total number of 12011 participants were included in the systematic review. The prevalence of MIH ranged from 5.1% to 25.6%. All of the included studies were at a moderate risk of bias (NOS of 4-6). The lowest prevalence of MIH was reported in Kerman (5.14%) and the highest in Tehran (25.6%). Substantial methodological, clinical and statistical heterogeneity was observed. Conclusion This is the first study to systematically review the available literature on MIH prevalence in Iran. However, the present review has some limitations such as limited number of included studies, large heterogeneity of the research, and moderate quality of included studies. Further high-quality research is warranted.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Prevalence of Molar-incisor hypomineralization in Iranian children – A systematic review and narrative synthesis

et al. 2022

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“…Considering the latest estimated MIH global prevalence of 13.5% [ 4 ], the cross-country variety may range from 2.8 to 40.2% [ 21 ]. The prevalence of MIH in Portugal has never been estimated, therefore we used the worldwide estimated result of 13.5%, yet 32.7% of the participants believe that this may range between 5 and 10%.…”

Section: Discussionmentioning

confidence: 99%

“…Presently, MIH is an increasingly common dental defect in clinical practice. Globally, its estimated worldwide prevalence is 13.5%, with affected incisors in 36.6% of the cases [ 4 ], and about 27.4% of cases require therapeutic interventions [ 5 ]. Clinically, MIH is characterized by the translucency of enamel with a white, yellow to brownish coloration depending on severity [ 3 , 6 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Knowledge, perception, and clinical experiences on molar incisor hypomineralization amongst Portuguese dentists

et al. 2022

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Aim Molar incisor hypomineralization (MIH) is a prevalent oral health condition whose knowledge by dentists is key to the best clinical outcome. This study aimed to evaluate the knowledge, perceptions and clinical experiences of MIH among Portuguese dentists. Methods A cross-sectional structured questionnaire was distributed nationally through a web-based survey platform. Data concerning demographic variables, years of experience, dental specialty, MIH prevalence, diagnosis, severity, training demands and clinical management of MIH were collected. We calculated a knowledge score (KS), and compared data between Pediatric Dentists (PDs), General Dental Practitioners (GDPs) and other dental specialties (ODS). Results Overall, 2.2% of Portuguese dentists (n = 257) answered the questionnaire. Most participants reported having identified MIH in their practice (82.5%), with PD reporting the prevalence appeared to have increased, and practically all (91.7%) considered it a public health problem. Resin composite was often the used material to restore MIH teeth (56.0%), however PDs indicated glass ionomer cements as the preferred and preformed crowns a better option. The average KS on MIH was 41.3 (± 5.7), with GDPs having a similar score than PDs. Most respondents (94.9%) reported a lack of information about MIH and were willing to receive appropriate clinical training. Conclusions The average knowledge on MIH was considered low among Portuguese dentists. Respondents perceived an increased incidence of MIH, despite the lack of prevalence data in Portugal. The material of choice was Glass Ionomer and performed crowns, by PDs, while GDPs and ODS reported poor confidence to manage MIH. These results may serve future programs to increase knowledge, perceptions and clinical experiences towards MIH.

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“…The NOS was used for assessing the risk of bias in clinical trials because their baseline assessments were considered in this meta-analysis. According to the obtained NOS scores, case–control studies were classified into three levels: low quality (0–4 points), medium quality (5–6) and high quality (7–9 points) and cross sectional studies were classified into four levels: unsatisfactory (0–4 points), satisfactory (5–6 points), good (7–8 points) and very good (9–10 points) (as previously performed 61 , 62 ). Any discrepancies were addressed by discussion to reach a consensus.…”

Section: Methodsmentioning

confidence: 99%

A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults

Yazdanpanah

Mozaffari‐Khosravi

Mirzaei³

et al. 2022

Sci Rep

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The cluster of differentiation 36 (CD36) is one of the main receptors implicated in the pathogenesis of the cardiovascular disease. This study aimed to assess the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors including body mass index (BMI), waist circumference (WC), total cholesterol (TC), triglyceride, HDL-C, LDL-C, blood pressure and fasting blood glucose (FBG). PubMed, EMBASE, Scopus, web of science, and Google Scholar were searched up to December 2021. Subgroup and meta-regression analyses were conducted to explore sources of heterogeneity. Eighteen eligible studies (6317 participants) were included in the study. In the overall analysis, a significant association was found between rs1761667 polymorphism of CD36 and TG in allelic (p < 0.001), recessive (p = 0.001) and homozygous (p = 0.006) models. A relationship between this polymorphism and HDL-C and FBG level was observed in the recessive genetic model. In the subgroup analysis, the A allele was associated with impaired lipid profiles (TC, LDL-C and HDL-C) in the Asian population. The influences of health status, design of the study, confounders, and other sources of heterogeneity should be considered when interpreting present findings. Cohort studies with large sample size and in different ethnicities are needed to confirm the relationship between rs1761667 SNP and cardiometabolic risk factors.

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The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis

Cited by 68 publications

References 119 publications

Prevalence of Molar-incisor hypomineralization in Iranian children – A systematic review and narrative synthesis

Prevalence of Molar-incisor hypomineralization in Iranian children – A systematic review and narrative synthesis

Knowledge, perception, and clinical experiences on molar incisor hypomineralization amongst Portuguese dentists

A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults

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