The Preventative Role of Curcumin on the Lung Inflammatory Response Induced by Cardiopulmonary Bypass in Rats

Curcumin Protects Against Sepsis-Induced Acute Lung Injury in Rats

“…IL-8 also could trigger neutrophil release, elastase, alkaline phosphatase, and 5-oxo-eicosatetraenoic acid, which contribute to tissue destruction [27]. Early studies have shown that curcumin partly prevents the elevation of IL-8 in lung induced by cardiopulmonary bypass in rats [28]. It was also demonstrated that curcumin decreased IL-8 expression in alveolar epithelial cells [29].…”

Pharmacological and clinical properties of curcumin

“…137 Curcumin also downregulated lung tissue expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and NF-κB, and significantly reduced the lung injury score of the treated rats. 137 In vitro, curcumin, in combination with maximal doses of genistein, was able to potentiate the channel activity of cystic fibrosis transmembrane conductance regulator (CFTR) bearing the G551D mutation up to 50% of the function of the wild type CFTR. 138 Co-application of curcumin and genistein over a lower concentration range was also able to rescue the gating defect of G551D-CFTR synergistically.…”

“…136 The respiratory system An in vivo study in rats demonstrated that pretreatment with curcumin exerted a potent protective effect on the lungs following cardiopulmonary bypass (CPB). 137 Specifically, curcumin pretreatment reduced plasma, bronchoalveolar lavage fluid, and lung tissue concentrations of IL-8, TNF-α, and MMP-9 caused by CPB. 137 Curcumin also downregulated lung tissue expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and NF-κB, and significantly reduced the lung injury score of the treated rats.…”

“…137 Specifically, curcumin pretreatment reduced plasma, bronchoalveolar lavage fluid, and lung tissue concentrations of IL-8, TNF-α, and MMP-9 caused by CPB. 137 Curcumin also downregulated lung tissue expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and NF-κB, and significantly reduced the lung injury score of the treated rats. 137 In vitro, curcumin, in combination with maximal doses of genistein, was able to potentiate the channel activity of cystic fibrosis transmembrane conductance regulator (CFTR) bearing the G551D mutation up to 50% of the function of the wild type CFTR.…”

Curcumin for the Prevention of Acute Lung Injury in Sepsis: Is It More Than the Flavor of the Month?

“…In studies examining prevention of radiation-induced lung injury, dietary curcumin was found to ameliorate pulmonary fibrosis and increased mouse survival while not impairing tumor cell killing by radiation [11]. In an article previously published in the Journal of Surgical Research, Liu et al demonstrated that curcumin helped to prevent cardiopulmonary bypass induced lung injury [12]. Unfortunately, the poor solubility of curcumin, due to its hydrophobic property and preferential interaction with lipid membranes, limits its bioavailability and clinical efficacy.…”