The prevention of heterotopic bone formation following total hip arthroplasty using 600 rad in a single dose

Hedley, Anthony K.; Mead, Leon P.; Hendren, Douglas H.

doi:10.1016/s0883-5403(89)80033-6

Cited by 76 publications

(22 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence of HO which we observed in our groups treated by irradiation is also similar to those previously published 9,10,[19][20][21][22][23][24] (Table II), although it must be emphasised that most of these series had been of high-risk patients. Postoperative irradiation with 1 ‫ן‬ 5 Gy and prophylaxis with acetylsalicylic acid gave significantly worse results than the other methods (Tables VI and VII (Tables VI and VII).…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Prevention of Heterotopic Ossification After Total Hip Replacement

Knelles

Barthel

Karrer

et al. 1997

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

We have carried out a prospective, randomised study of prophylaxis for heterotopic ossification (HO) comparing indomethacin for 7 and 14 days, acetylsalicylic acid, and fractional (4 ‫ן‬ 3 Gy) or single exposure of 5 or 7 Gy irradiation after operation.We initially had 723 patients (733 hip replacements), but after withdrawals there were 685 hips of which 18.4% developed HO; 14% were grade I, 2.9% grade II and 1.5% grade III of the Brooker classification.We compared the results between these groups with those of a matched control series and found that indomethacin, 2 ‫ן‬ 50 mg for 7 and 14 days, and postoperative irradiation of 4 ‫ן‬ 3 Gy or 1 ‫ן‬ 7 Gy, significantly reduced the development of HO compared with the control group. Patients in the acetylsalicylic acid group and those with a single irradiation of 5 Gy after operation developed significantly more ossification than those in the indomethacin and other irradiation groups.We suggest the use of 2 ‫ן‬ 50 mg of indomethacin with mucoprotection for seven days as prophylaxis against HO after total hip replacement for all patients. A single irradiation of 7 Gy is recommended for patients who have developed HO after previous operations or to whom administration of indomethacin is contraindicated.

show abstract

Section: Discussionsupporting

confidence: 90%

“…More recently, single doses of irradiation have been used after operation. Lo et al 9 used 7 Gy and Hedley, Mead and Hendren 10 6 Gy (Table II).…”

Section: From the University Of Würzburg Germanymentioning

confidence: 99%

Prevention of Heterotopic Ossification After Total Hip Replacement

Knelles

Barthel

Karrer

et al. 1997

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

show abstract

“…Heterotopic bone formation after total hip arthroplasty can be prevented by postoperative treatment with anti-inflammatory drugs for the first 2 to 6 weeks (Kjaersgaard- Andersen and Schmidt 1986, Schmidt et al 1988, Kjzrsgaard-Andersen and Ritter 1990b or by single-dose irradiation of the hip during the first postoperative week (Hedley et al 1989, Lo et al 1988.…”

Section: Discussionmentioning

confidence: 99%

Heterotopic bone formation following hip arthroplasty: A retrospective study of 65 bilateral cases

Kjægaard-Andersen¹,

Steinke²,

Hougaard³

et al. 1991

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

“…Some anti-inflammatory medications possess analgesic properties and also may help to prevent heterotopic ossification. 35,36 For additional pain control, continuous brachial plexus blockade may be helpful in the early postoperative period (from 24 to 48 hours) and may facilitate early mobilization of the elbow. 37 Some evidence exists that continuous passive motion may be helpful in obtaining 292 / K.J.…”

Section: Postoperative Carementioning

confidence: 99%