The priming saga: where do we stand now?

Donati, François

doi:10.1007/bf03010535

Cited by 21 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The first group used pancuronium 0.015 mg/kg as a priming dose that was followed 3 minutes later by the intubating dose (0.08 mg/kg) after anesthesia induction. 67 Han and Martyn 68 compared onset and tracheal ICs after a large bolus of rocuronium with those after the use of the priming technique both in burn patients and controls. 59 The second group used vecuronium 0.015 mg/kg as a priming dose followed 6 minutes later by vecuronium 0.05 mg/kg as an intubating dose and found that intubation time had decreased to 61 seconds.…”

Section: The Use Of Nondepolarizing Nmbds For Rsii: the Priming And Tmentioning

confidence: 99%

Rapid Sequence Induction and Intubation

El-Orbany

Connolly

2010

Anesthesia &Amp; Analgesia

213

152

View full text Add to dashboard Cite

The changing opinion regarding some of the traditional components of rapid sequence induction and intubation (RSII) creates wide practice variations that impede attempts to establish a standard RSII protocol. There is controversy regarding the choice of induction drug, the dose, and the method of administration. Whereas some prefer the traditional rapid injection of a predetermined dose, others use the titration to loss of consciousness technique. The timing of neuromuscular blocking drug (NMBD) administration is different in both techniques. Whereas the NMBD should immediately follow the induction drug in the traditional technique, it is only given after establishing loss of consciousness in the titration technique. The optimal dose of succinylcholine is controversial with advocates and opponents for both higher and lower doses than the currently recommended 1.0 to 1.5 mg/kg dose. Defasciculation before succinylcholine was traditionally recommended in RSII but is currently controversial. Although the priming technique was advocated to accelerate onset of nondepolarizing NMBDs, its use has decreased because of potential complications and the introduction of rocuronium. Avoidance of manual ventilation before tracheal intubation was traditionally recommended to avoid gastric insufflation, but its use is currently acceptable and even recommended by some to avoid hypoxemia and to "test" the ability to mask ventilate. Cricoid pressure remains the most heated controversy; some believe in its effectiveness in preventing pulmonary aspiration, whereas others believe it should be abandoned because of the lack of scientific evidence of benefit and possible complications. There is still controversy regarding the best position and whether the head-up, head-down, or supine position is the safest during induction of anesthesia in full-stomach patients. These controversial components need to be discussed, studied, and resolved before establishing a standard RSII protocol.

show abstract

Section: The Use Of Nondepolarizing Nmbds For Rsii: the Priming And Tmentioning

confidence: 99%

Rapid Sequence Induction and Intubation

El-Orbany

Connolly

2010

Anesthesia &Amp; Analgesia

213

152

View full text Add to dashboard Cite

show abstract

“…There is much controversy about the magnitude of the priming dose to be used. Some authors 2,8,16,17 mention that doses equal to or above 10% of the effective 95 (DE 95 ) dose would bring fade risk. Recently, Kopman et al 18 have published, in a study with computer emulation, that the 10% DE 95 dose would seldom cause fade, but that 1 out of 50 patients would present fade with 10% of the tracheal intubation dose.…”

Section: Resultsmentioning

confidence: 99%

Dose preparatória de atracúrio: aferição da fadiga no músculo orbicular do olho e condições de intubação orotraqueal

Locks¹,

Almeida²

2003

Rev. Bras. Anestesiol.

View full text Add to dashboard Cite

show abstract

“…11 However, in this investigation, we used a higher priming dose (25% to 30% of ED 95 ) to determine whether the onset time of cisatracurium could approach that of succinylcholine (60 sec), 12 and to ascertain the effect of high-dose priming on neuromuscular transmission by measuring the T1% and TOF values. Repetitive stimulation to the neuromuscular T1% ϭ percentage of the first twitch height; T1:T4 ϭ ratio of the first and fourth twitch.…”

Section: Discussionmentioning

confidence: 99%