The Probiotic Butyricicoccus pullicaecorum Reduces Feed Conversion and Protects from Potentially Harmful Intestinal Microorganisms and Necrotic Enteritis in Broilers

Eeckhaut, Venessa; Wang, Jun; Parys, Alexander Van; Haesebrouck, Freddy; Joossens, Marie; Falony, Gwen; Raes, Jeroen; Ducatelle, Richard; Immerseel, Filip Van

doi:10.3389/fmicb.2016.01416

Cited by 119 publications

(95 citation statements)

References 53 publications

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“…Members of the genus Butyricicoccus are tolerant to changing intestinal conditions, produce butyrate, and have probiotic potential (57,58). In addition, Butyricicoccus is known to inhibit growth of potentially harmful intestinal pathogens and protect the intestine from the formation of necrotic enteritis in broilers (59). Members of the genus Phyllobacterium are known to have heavy metal resistance genes.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

Gokulan

Arnold

Jensen

et al. 2018

mBio

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Intestinal microbiota composition and gut-associated immune response can contribute to the toxicity of arsenic. We investigated the potential toxicity of short-term arsenic exposure on gut microbiome composition, intestinal immune status, microbial arsenic resistance gene, and arsenic metabolic profiles in adult and developmental stages of CD-1 mice. The potential toxicity of arsenite [As(III)] was determined for two life stages: (i) adult animals at 24 or 48 h after single gavage (0.05 mg/kg body weight [b.w.] [low dose], 0.1 mg/kg b.w. [medium dose], and 0.2 mg/kg b.w. [high dose]) and repeated exposure at 1 mg/liter for 8 days and (ii) postnatal day 10 (PND10) and PND21 after single gavage (0.05 mg/kg b.w.). Dose- and time-dependent responses in bacterial recovery/microbial composition were observed in adults after a single gavage. Repeated exposure caused a transient decrease in the recovery of intestinal bacteria, a shift in the bacterial population with abundance of arsenic resistance genes, and evidence for host metabolism of arsenite into less-reactive trivalent methylated species. Arsenic exposure in adult animals induced high levels of CC chemokines and of proinflammatory and anti-inflammatory cytokine secretion in intestine. Arsenic exposure at PND21 resulted in the development of distinct bacterial populations. Results of this study highlight significant changes in the intestinal microbiome and gut-associated immune status during a single or repeated exposure to arsenic in juvenile and adult animals. The data warrant investigation of the long-term effects of oral arsenic exposure on the microbiome and of immune system development and responses. Transformation of organic arsenic to toxic inorganic arsenic (iAs) is likely carried out by intestinal bacteria, and iAs may alter the viability of certain microbial populations. This study addressed the impact of arsenic exposure on intestinal microbiota diversity and host gut-associated immune mediators during early development or adulthood using scenarios of acute or repeated doses. During acute arsenic exposure, animals developed defense functions characterized by higher abundances of bacteria that are involved in arsenic resistance or detoxification mechanisms. Arsenite had a negative effect on the abundance of bacterial species that are involved in the conversion of protein to butyrate, which is an alternative energy source in the intestine. The intestinal mucosal immune cytokine profile reflected a mechanism of protection from arsenic toxicity.

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Section: Discussionmentioning

confidence: 99%

Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

Gokulan

Arnold

Jensen

et al. 2018

mBio

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“…Ruminococcaceae represent major butyrate producers. The majority of Ruminococcaceae produce butyrate by carbohydrate fermentation via conversion of two acetyl-CoA molecules into crotonyl-CoA [30,[33][34][35]. In addition, Flavonifractor and Pseudoflavinofractor can produce butyrate also by lysine fermentation or by reduction of succinate.…”

Section: Major Bacterial Taxa Colonising Chicken Intestinal Tractmentioning

confidence: 99%

Composition and Function of Chicken Gut Microbiota

Rychlı́k

2020

Animals

264

203

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Studies analyzing the composition of gut microbiota are quite common at present, mainly due to the rapid development of DNA sequencing technologies within the last decade. This is valid also for chickens and their gut microbiota. However, chickens represent a specific model for host–microbiota interactions since contact between parents and offspring has been completely interrupted in domesticated chickens. Nearly all studies describe microbiota of chicks from hatcheries and these chickens are considered as references and controls. In reality, such chickens represent an extreme experimental group since control chicks should be, by nature, hatched in nests in contact with the parent hen. Not properly realising this fact and utilising only 16S rRNA sequencing results means that many conclusions are of questionable biological relevance. The specifics of chicken-related gut microbiota are therefore stressed in this review together with current knowledge of the biological role of selected microbiota members. These microbiota members are then evaluated for their intended use as a form of next-generation probiotics.

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“…Eeckhaut et al [87] reported that probiotic Butyricicoccus pullicaecorum can prevent NE in the digestive tract of broiler chickens by reducing the number of potentially important pathogens in the caeca and ileum. In our recent study, the intestine samples from Gallipro-or Clostat-supplemented diets were examined and found to show a normal tissue architecture with normal intestinal villi ( Figure 2F) and moderate metaplasia of the intestinal epithelium into goblet cells ( Figure 3G), in addition to a negative control group (Figure 2A).…”

Section: Liver and Intestinal Histopathological Signsmentioning

confidence: 99%

Effect of Antibiotic, Phytobiotic and Probiotic Supplementation on Growth, Blood Indices and Intestine Health in Broiler Chicks Challenged with Clostridium perfringens

Hussein

Ahmed

Abudabos

et al. 2020

Animals

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Simple Summary: Necrotic enteritis is one of the most important economic issues in the poultry industry, associated with sudden death rates of up to 50%. However, there is limited information on the role of probiotics and/or phytobiotic compounds on the treatment and prevention of Clostridium perfringens infections in broiler chicks. This study aimed to assess the effects of probiotic compounds (Maxus, CloStat, Sangrovit Extra, CloStat + Sangrovit Extra and Gallipro Tech) on the growth performance, blood biochemistry and intestinal health of broiler chicks in vivo. The results demonstrated that the inclusion of probiotic and/or phytobiotic compounds has a positive effect on performance, blood constituents, liver histopathology, intestinal morphology and histopathology. Furthermore, a notable reduction in both lesion scores was observed when probiotics and phytobiotics alone or in combination were included in the diets.Abstract: This study evaluated the effects of feed additives on the growth, blood biochemistry and intestinal health of broiler chicks. A total of 378 of broiler chicks (Ross 308) were randomly allotted to seven groups. Chicks were fed a basal diet with 0.0 (control negative), 0.0 (control positive), 0.1, 0.5, 0.12, 0.5 + 0.12 and 0.2 g Kg −1 of Maxus, CloStat, Sangrovit Extra, CloStat + Sangrovit Extra and Gallipro Tech, respectively for 35 days. After 15 days, the chicks were inoculated with Clostridium perfringens. All feed additives were found to enhance growth performance and feed efficiency. The best feed conversion ratio was found in the Negative Control, CloStat + Sangrovit Extra and Gallipro Tect groups, respectively. A notable increase in villus length, total villus area, small intestine weight, ilium weight and total lesion score was found in chicks supplemented with Bacillus subtilis. Besides, the dietary inclusion of phytobiotic compounds showed potential in reducing the serum Alanine aminotransferase (ALT) concentration and increasing the glucose levels. All intestine and liver histopathological signs were reduced in chicks fed a probiotic-supplemented diet. Our findings indicate that supplementation with probiotics and phytobiotics alone or in combined form can be

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The Probiotic Butyricicoccus pullicaecorum Reduces Feed Conversion and Protects from Potentially Harmful Intestinal Microorganisms and Necrotic Enteritis in Broilers

Cited by 119 publications

References 53 publications

Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status

Composition and Function of Chicken Gut Microbiota

Effect of Antibiotic, Phytobiotic and Probiotic Supplementation on Growth, Blood Indices and Intestine Health in Broiler Chicks Challenged with Clostridium perfringens

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