The probiotic Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat diet-treated rats

Cavalcante, Raíssa Georgianna Silva; Albuquerque, Thatyane Mariano Rodrigues de; Freire, Micaelle Oliveira de Luna; Ferreira, Georgianna de Araújo Henriques; Santos, Lucas Alves Carneiro dos; Magnani, Marciane; Cruz, José Jaime da; Braga, Valdir de Andrade; Souza, Evandro Leite de; Alves, José Luiz de Brito

doi:10.1016/j.numecd.2019.08.003

Cited by 54 publications

(33 citation statements)

References 43 publications

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“…CVD is the main cause of morbidity and mortality in the world, there is currently a search for methods of treating elevated blood cholesterol. Researchers suggest that high-fat diet consumption has been associated with gut dysbiosis and lead to dyslipidemia, hypertension and T2D mellitus [122]. In addition, SCFAs have the ability to modulate CVD risk factors, including blood pressure reduction and regulation of glucose and lipid homeostasis [123].…”

Section: Cardiovascular Disease (Cvd)mentioning

confidence: 99%

“…A different study was designed to determination of the probiotic effect of Lactobacillus fermentum 296 on cardiometabolic disorders induced by high-fat diet in a rat model [122]. The probiotic was administrated by oral gavage to rats for 4 weeks.…”

Section: Cardiovascular Disease (Cvd)mentioning

confidence: 99%

“…Results of this research suggest the ability of Lactobacillus fermentum 296 improve cardiovascular and biochemical parameters altered in cardiometabolic disorders. The increased production of short-chain fatty acids which modulate vasodilatation and induce hypotension has been proposed as possible mechanism of action this probiotic strain [122].…”

Section: Cardiovascular Disease (Cvd)mentioning

confidence: 99%

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The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

2020

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The relationship between diet and the diversity and function of the intestinal microbiome and its importance for human health is currently the subject of many studies. The type and proportion of microorganisms found in the intestines can determine the energy balance of the host. Intestinal microorganisms perform many important functions, one of which is participation in metabolic processes, e.g., in the production of short-chain fatty acids—SCFAs (also called volatile fatty acids). These acids represent the main carbon flow from the diet to the host microbiome. Maintaining intestinal balance is necessary to maintain the host’s normal health and prevent many diseases. The results of many studies confirm the beneficial effect of probiotic microorganisms on the balance of the intestinal microbiome and produced metabolites, including SCFAs. The aim of this review is to summarize what is known on the effects of probiotics on the production of short-chain fatty acids by gut microbes. In addition, the mechanism of formation and properties of these metabolites is discussed and verified test results confirming the effectiveness of probiotics in human nutrition by modulating SCFAs production by intestinal microbiome is presented.

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Section: Cardiovascular Disease (Cvd)mentioning

confidence: 99%

Section: Cardiovascular Disease (Cvd)mentioning

confidence: 99%

Section: Cardiovascular Disease (Cvd)mentioning

confidence: 99%

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The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

2020

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“…LAB with health benefits, such as lactobacilli, are considered probiotics. Probiotics have been reported to help treat colitis (Kim et al, 2019), cardiometabolic disorder (Cavalcante et al, 2019), insulin resistance (Bagarolli et al, 2017), sympathetic hyperactivity (Yamano et al, 2006), and cancer (Abedi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Anti‐obesity effect of Lactobacillus plantarum CQPC01 by modulating lipid metabolism in high‐fat diet‐induced C57BL/6 mice

et al. 2020

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Lactic acid bacteria (LAB) are an important group of microorganisms in the food industry. LAB with health benefits are considered natural elements promoting consumer health. The study investigated the anti-obesity effects of Lactobacillus plantarum CQPC01 (LP-CQPC01) on high-fat diet-induced mice. Liver morphology, liver function indexes, lipid indexes, and inflammatory factors in the serum and liver were determined. Expressions of lipid metabolism-related gene were also detected by qPCR. LP-CQPC01 slowed the HFD-induced increase in body weight, decreased the organ indexes, alleviated hepatic lipid accumulation, and inhibited the increased adipose cell volume. LP-CQPC01 decreased lipid levels of serum and liver, and the contents of pro-inflammatory factors, and increased the IL-4 and IL-10 contents. LP-CQPC01 downregulated the expressions of the C/EBP-α and PPARγ mRNA and upregulated CYP7A1, CPT1, LPL, CAT, SOD1, and SOD2 mRNA. Our results indicated that LP-CQPC01 is a potential probiotic for preventing or alleviating high-energy intakerelated lipid conditions. Practical applications Obesity is a factor of a variety of cardiovascular diseases. Therefore, it is necessary to suppress the occurrence of fat accumulation in time. This study investigated the effect of LP-CQPC01 on lipid regulation in mice fed a high-fat diet (HFD) and clarified the mechanism of strain to alleviate obesity by enhancing the decomposition of cholesterol and detoxification of fat. LP-CQPC01 reduced fat accumulation without oxidative damage, and was confirmed by the attenuated pathological changes of liver. This research can serve as a significant reference for future research, prevention, and treatment of high-energy intake-related lipid conditions, and the development of functional foods with anti-obesity activity.

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“…Recent studies considered the use of Lactobacillus spp. in the prevention and treatment of inflammatory bowel disease [3,4] , food hypersensitivity [5] , cardiometabolic disorders [6] and anti-tumor activity [7] .…”

Section: Introductionmentioning

confidence: 99%

Investigation of Lactobacillus paracasei encapsulation in electrospun fibers of Eudragit® L100

et al. 2020

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Some species of Lactobacillus have demonstrated beneficial health effects being applied in the production of food supplements. Thus, the incorporation of viable cells as encapsulated probiotics represents an essential condition to be considered in new strategies for the controlled release of microorganisms. Herein, the massive encapsulation of Lactobacillus paracasei is provided by the use of alternative electrospinning technique. Is spite of the high voltage required for the production of fibers, a high density of viable cells is observed into the polymeric electrospun web, allowing the controlled release at targeted pH (characteristic of Eudragit® L100 polymer support). The reported procedure circumvents typical drawbacks of degradation of microorganisms under adverse conditions (storage, package and low pH) and preserves its biologic action after complete release from polymer fibers.

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The probiotic Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat diet-treated rats

Cited by 54 publications

References 43 publications

The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

Anti‐obesity effect of Lactobacillus plantarum CQPC01 by modulating lipid metabolism in high‐fat diet‐induced C57BL/6 mice

Investigation of Lactobacillus paracasei encapsulation in electrospun fibers of Eudragit® L100

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